DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5087 and HUL4

DIOPT Version :9

Sequence 1:	NP_648279.1	Gene:	CG5087 / 39035	FlyBaseID:	FBgn0035953	Length:	1078	Species:	Drosophila melanogaster
Sequence 2:	NP_012570.3	Gene:	HUL4 / 853494	SGDID:	S000003797	Length:	892	Species:	Saccharomyces cerevisiae

Alignment Length:	942	Identity:	204/942 - (21%)
Similarity:	338/942 - (35%)	Gaps:	262/942 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   237 IITLCLRPLIDGNFSRNLLAKFLSEILSVPALIYHLQQSVPQC---LEQFSSMGLLKKALSISGD 298
            :..:...|.|:.|         |.....:...:..||..|.:|   |::....|:|.|.
Yeast   107 VTVIVKEPEINSN---------LESSTHISCTLEGLQMVVRRCHDDLQRLKKTGILDKE------ 156

  Fly   299 VQWFEEFGTSMPGTKSLAFLGNI---------VNLFN-----IDGQGESKELAYPLLTETTTSLL 349
                         .|.|.|...|         |::.|     .||....|.|.|.:| :...|:|
Yeast   157 -------------RKGLIFQPVITYLLDRFHDVSILNRSFLVHDGGKNIKMLNYEVL-QRFYSIL 207

  Fly   350 ELIPNTVTTKGVFTQWHELLGWHTPGPEPAQNQNVALIKKQFHMLWDHRCIKLLLGDLLKQINLN 414
            ..:|..                                |..:.||    |   ...||||:|.:|
Yeast   208 SNLPTR--------------------------------KPYYSML----C---CCNDLLKRITIN 233

  Fly   415 Y-ERIEFQSPQQ-------PSISNLLRRALERSSTRGVNLMGVASSKQSK-----QQWRKLDSAE 466
            . |.::....:.       |:|...|.|                 .::||     ||.|    |.
Yeast   234 KGENLQILQYRWLLIILNIPTIRTCLIR-----------------DRKSKNVFETQQIR----AV 277

  Fly   467 VVQVSRICGMYYAALNTLSQMKLDILTGICYSDNVLYDIWLLITSLGPNCGMKEYLELLKSE--- 528
            ..::::.|..|.:.|:|.:..:|........:||..|.:.:|  :|..|.   ::..||.:|
Yeast   278 SYELAKRCIGYLSNLSTKTSQQLIQSLRRTPTDNFSYQVEIL--NLYINF---QFSRLLSNELSN 337

  Fly   529 ---TNLQKPQTAMLMLFCDCMTHYVT---ILDEHEMYTEQN---------------PFKLNDY-- 570
               .|..||:..|....   ..|:.|   .|....:..:.|               .||...|
Yeast   338 RTAKNNVKPEDEMRSRL---RRHHTTGHEFLSTRPISAQSNDKQGSGFTHPVNNKMKFKFFQYEE 399

  Fly   571 -------VLLTYFLNNILYKLINDNLLA-GAKNIVQHPVFLSLHTLMLCLYRRDCRRPFTPPKHW 627
                   ..||:     :|.:.|..... ||.:|..   |.:: ||....|::|.       .||
Yeast   400 DWHIHSAAKLTF-----IYYVANTRRNGRGALSIQS---FYNI-TLDFIDYKQDF-------DHW 448

  Fly   628 --LIPEVKPSTFINDLEKAKRNAMLLLAKMPHIIPHEDRVKL----FRKFVQN--EKAVMGLTES 684
              :..:.|.:..|.:...:.........|.|.|:....::.:    .|:.:::  |:|.:...:.
Yeast   449 RGVAQKTKMNQLIEEWGNSTTKKCFSFCKYPFILSLGIKISIMEYEIRRIMEHEAEQAFLISLDK 513

  Fly   685 ACASPRSALIVIHRDRIVEDGYRQLAAQPTQALKGVIRVRFINQQGLHEAGIDQDGVFKEFLEET 749
            ..:......|.:.||.|..|..|.:.......||. :|:.|:|     |.|||..|:.||:....
Yeast   514 GKSVDVYFKIKVRRDVISHDSLRCIKEHQGDLLKS-LRIEFVN-----EPGIDAGGLRKEWFFLL 572

  Fly   750 IKKVFDPSLNLF---KTTSDQRLYPSPISY----VQDNHLELFEFVGRMLGKAVYEGIVVDVPFA 807
            .|.:|:|...||   |.:|.......|.::    .:::.|||:...|.::|.|::...::|:.|
Yeast   573 TKSLFNPMNGLFIYIKESSRSWFAIDPPNFDKSKGKNSQLELYYLFGVVMGLAIFNSTILDLQF- 636

  Fly   808 SFFLSQLLGQTQQALYS--CMDEL---------PSLDNELYRSLTFIKHYKQDVSDLNLTFSV-- 859
                       .:|||.  |.:.|         |.....|.:.|.:.:...:||  .:|||..
Yeast   637 -----------PKALYKKLCSEPLSFEDYSELFPETSRNLIKMLNYTEDNFEDV--FSLTFETTY 688

  Fly   860 --------DQDVMGKIVTLALHPGGKARVVNDHNKLVYIHYMAFFHMNTQIREQTIAFNRGFRSI 916
                    |.....:.||:.|...|:...:...||..::.....|::...|..|...|..||:.:
Yeast   689 RNNNWILNDSKSSKEYVTVELCENGRNVPITQSNKHEFVMKWVEFYLEKSIEPQYNKFVSGFKRV 753

  Fly   917 -VNPEWLSLFSPPELQRLISGD--TSPLDLKDLQKHTHYYGGFHDTHQVVCWLWDILAKDFTEEE 978
             .....:.||:..||:||:.||  .:..|.|.|:..|.|.|||.|..:.|||.|:|: :.:....
Yeast   754 FAECNSIKLFNSEELERLVCGDEEQTKFDFKSLRSVTKYVGGFSDDSRAVCWFWEII-ESWDYPL 817

  Fly   979 RKLFLKFVTSCSKPPLLGFAHLEPPFSIRCVEVSDDEDTGDTIGSVIRGFFAIRKKDPLNRLPTS 1043
            :|..|:|||:..:.|..|.:.:  ||.|..:...|.:|                       ||.:
Yeast   818 QKKLLQFVTASDRIPATGISTI--PFKISLLGSHDSDD-----------------------LPLA 857

  Fly  1044 STCFNLLKLPNYQKKSTLRDKLRYAVSSNTGF 1075
            .||||.:.|.||..|..|..||.:|::.:.|:
Yeast   858 HTCFNEICLWNYSSKKKLELKLLWAINESEGY 889

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5087	NP_648279.1	HECTc	694..1076	CDD:238033	109/413 (26%)
CG5087	NP_648279.1	HECTc	718..1075	CDD:214523	101/387 (26%)
HUL4	NP_012570.3	HUL4	1..892	CDD:227354	204/942 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810