DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5087 and Nedd4l

DIOPT Version :9

Sequence 1:	NP_648279.1	Gene:	CG5087 / 39035	FlyBaseID:	FBgn0035953	Length:	1078	Species:	Drosophila melanogaster
Sequence 2:	XP_036017204.1	Gene:	Nedd4l / 83814	MGIID:	1933754	Length:	1261	Species:	Mus musculus

Alignment Length:	427	Identity:	121/427 - (28%)
Similarity:	207/427 - (48%)	Gaps:	50/427 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly   655 MPHIIPHEDRVKLFRKFVQNEKAVMGLTESACASPRSALIVIHRDRIVEDGYRQ-LAAQPTQALK 718
            :|:....:.:...|||.::....:          |....:.:||:.|.|:.||: ::.:....||
Mouse   877 VPYSREFKQKYDYFRKKLKKPADI----------PNRFEMKLHRNNIFEESYRRIMSVKRPDVLK 931

  Fly   719 GVIRVRFINQQGLHEAGIDQDGVFKEFLEETIKKVFDPSLNLFK--TTSDQRLYPSPIS-YVQDN 780
            ..:.:.|.:::||     |..||.:|:.....|::|:|...||:  .|.:..|..:|.| ...::
Mouse   932 ARLWIEFESEKGL-----DYGGVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNED 991

  Fly   781 HLELFEFVGRMLGKAVYEGIVVDVPFASFFLSQLLGQTQQALYSCMDELPSLDNELYRSLTFIKH 845
            ||..|.|:||:.|.||:.|.::|..|...|...:||:     ...::::.|:|:|.|.||.:|
Mouse   992 HLSYFTFIGRVAGLAVFHGKLLDGFFIRPFYKMMLGK-----QITLNDMESVDSEYYNSLKWI-- 1049

  Fly   846 YKQDVSDLNLTFSVDQDVMGKIVTLALHPGGKARVVNDHNKLVYIHYMAFFHMNTQIREQTIAFN 910
            .:.|.::|:|.|.:|::..|:...:.|.|.|...:|.:.||..||..:..:....::::|..||.
Mouse  1050 LENDPTELDLMFCIDEENFGQTYQVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFL 1114

  Fly   911 RGFRSIVNPEWLSLFSPPELQRLISGDTSPLDLKDLQKHTHYYGGFHDTHQVVCWLWD-ILAKDF 974
            .||..::..:.:.:|...||:.|:.| ...:|:.|.::|:.|..|:...|.|:.|.|. :|..|
Mouse  1115 EGFTELLPIDLIKIFDENELELLMCG-LGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMD- 1177

  Fly   975 TEEERKLFLKFVTSCSKPPLLGFAHLEPPFSIRCVEVSDDEDTGDTIGSVIRGFFAIRKKDPLNR 1039
             .|:|...|:|||..|:.|:.|||.|                    .||.....|.|.:.....:
Mouse  1178 -AEKRIRLLQFVTGTSRVPMNGFAEL--------------------YGSNGPQLFTIEQWGSPEK 1221

  Fly  1040 LPTSSTCFNLLKLPNYQKKSTLRDKLRYAVSSNTGFE 1076
            ||.:.||||.|.||.|:....||:||..||.:..|||
Mouse  1222 LPRAHTCFNRLDLPPYETFEDLREKLLMAVENAQGFE 1258

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5087	NP_648279.1	HECTc	694..1076	CDD:238033	114/386 (30%)
CG5087	NP_648279.1	HECTc	718..1075	CDD:214523	106/360 (29%)
Nedd4l	XP_036017204.1	PHA03378	<107..318	CDD:223065
		C2	<367..420	CDD:417471
		WW	465..491	CDD:395320
		WW	655..684	CDD:395320
		WW	768..798	CDD:238122
		WW	817..867	CDD:197736
		HECTc	928..1257	CDD:214523	107/363 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810