DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5087 and WWC2

DIOPT Version :9

Sequence 1:	NP_648279.1	Gene:	CG5087 / 39035	FlyBaseID:	FBgn0035953	Length:	1078	Species:	Drosophila melanogaster
Sequence 2:	XP_011530571.1	Gene:	WWC2 / 80014	HGNCID:	24148	Length:	1216	Species:	Homo sapiens

Alignment Length:	833	Identity:	155/833 - (18%)
Similarity:	263/833 - (31%)	Gaps:	284/833 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   177 KSWAILRNAQFEKLQPAMQKICCNIQGHLVQHDFYKIMRLVLIRGTVREELSVKPVTLVAIITLC 241
            |...:.:...||.||...:|:.....|:.:......:..|..||..:......|...:.::..|.
Human   186 KQELLYKEQGFETLQQIDKKMSGGQSGYELSEAKAILTELKSIRKAISSGEKEKQDLMQSLAKLQ 250

  Fly   242 LRPLIDGNFSRNLLAKFLSEILSVPALIYHLQQSVPQCLEQFSSMGLLKKAL------SISGDVQ 300
            .|..:|.|..|           |.|.|         :|....|.:.|.::.|      |||||:
Human   251 ERFHLDQNIGR-----------SEPDL---------RCSPVNSHLCLSRQTLDAGSQTSISGDI- 294

  Fly   301 WFEEFGTSMPGTKSLAFLGNIVNLFNIDGQGESKELAYPLLTETTTSL-LELIPNTVTTKGVFTQ 364
                      |.:|.:.|...|.|          .|.|.....:..:| :||      :|.....
Human   295 ----------GVRSRSNLAEKVRL----------SLQYEEAKRSMANLKIEL------SKLDSEA 333

  Fly   365 WHELLGWHTPGPEPAQNQNVALIKKQFHMLWDHRCIKLLLGDLLKQINLNYERIEFQSPQQPSIS 429
            |        ||....:.:.:.||.::              .:|||:       ::|.:||:.:..
Human   334 W--------PGALDIEKEKLMLINEK--------------EELLKE-------LQFVTPQKRTQD 369

  Fly   430 NLLRRALERS-------STRGVNLMGVAS----SKQSKQQWRKLDSAEVVQVSRICGMYYAALNT 483
            .|.|...||.       |.||.....:|.    .::.|:..:||:     :.:::....::.|.:
Human   370 ELERLEAERQRLEEELLSVRGTPSRALAERLRLEERRKELLQKLE-----ETTKLTTYLHSQLKS 429

  Fly   484 LSQMKLDILTGICYSDNVLYDIWLLITSLGPNCGMKEYLELLKSETNLQKPQTAMLMLFCDCMTH 548
            ||...|.:.:|               :|||         .|..|..:|.......|........:
Human   430 LSASTLSMSSG---------------SSLG---------SLASSRGSLNTSSRGSLNSLSSTELY 470

  Fly   549 YVTILDEHEMYTEQNPFKLNDYVLLTYFLNNILYKLINDNLLAGAKNIVQHPVFLSLHTLMLCLY 613
            |.:..|:.::          ||          .|||  |.||
Human   471 YSSQSDQIDV----------DY----------QYKL--DFLL----------------------- 490

  Fly   614 RRDCRRPFTPPKHWLIPEVKPSTFINDLEKAKRNAM--------LLLAKMPHIIPHEDRVKLFRK 670
                     ..|...||. .|.|.|::.|..|..:.        :..|...|..|
Human   491 ---------QEKSGYIPS-GPITTIHENEVVKSPSQPGQSGLCGVAAAATGHTPP---------- 535

  Fly   671 FVQNEKAVMGLTE----SACASPRSALIVIHRDRIVEDGYRQLAAQPTQALKGVIRVRFINQQGL 731
            ..:..|:|..|:.    |:.:.|.|.|:                      |:|...:...:...|
Human   536 LAEAPKSVASLSSRSSLSSLSPPGSPLV----------------------LEGTFPMSSSHDASL 578

  Fly   732 HEAGIDQDGVFKEFLEETIKKVFDPSL--NLFKTTSDQRLYPSPISYVQDNHLELFEFVGRMLGK 794
            |:...|    |::.  |......|.||  |.....||.......:|..:|        :.....:
Human   579 HQFTAD----FEDC--ELSSHFADISLIENQILLDSDSGGASQSLSEDKD--------LNECARE 629

  Fly   795 AVYEGIV-VDVPFASFFLSQLLGQTQQALYSCM-DELPSLDNELYRSLTFIKHYKQDVSDLNLTF 857
            .:|||.. |:.......:..|||:....:.:.: ||..:.|:.:|.:  |:|. ..::.|  :|:
Human   630 PLYEGTADVEKSLPKRRVIHLLGEKTTCVSAAVSDESVAGDSGVYEA--FVKQ-PSEMED--VTY 689

  Fly   858 SVDQDVM---GKIVTLALHPGGK--------ARVVNDHNKLVYIHYMAFFHM------------- 898
            | ::||.   ...|.:.|....|        |::.|.|..|:......:|.:
Human   690 S-EEDVAIVETAQVQIGLRYNAKSSSFMVIIAQLRNLHAFLIPHTSKVYFRVAVLPSSTDVSCLF 753

  Fly   899 NTQIREQT--IAFNRGFRSIVNPEWLSLFSPPELQRLISGDTSPLDLKDLQKH 949
            .|::...|  |.||..||..::            |..:...|..:||..:.||
Human   754 RTKVHPPTESILFNDVFRVAIS------------QTALQQKTLRVDLCSVSKH 794

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5087	NP_648279.1	HECTc	694..1076	CDD:238033	54/286 (19%)
CG5087	NP_648279.1	HECTc	718..1075	CDD:214523	53/262 (20%)
WWC2	XP_011530571.1	WW	12..41	CDD:278809
		WW	59..88	CDD:278809
		DUF342	<283..385	CDD:302792	31/157 (20%)
		YlqD	351..>428	CDD:287979	17/102 (17%)
		C2_Kibra	700..823	CDD:176062	21/107 (20%)
		vWFA	<1058..>1153	CDD:294047
		Phage_Nu1	<1117..1192	CDD:294991
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900