DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5087 and ube3a

DIOPT Version :9

Sequence 1:	NP_648279.1	Gene:	CG5087 / 39035	FlyBaseID:	FBgn0035953	Length:	1078	Species:	Drosophila melanogaster
Sequence 2:	NP_001007319.1	Gene:	ube3a / 792398	ZFINID:	ZDB-GENE-041114-190	Length:	857	Species:	Danio rerio

Alignment Length:	730	Identity:	172/730 - (23%)
Similarity:	305/730 - (41%)	Gaps:	156/730 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   437 ERSSTRGVNLMGVASSKQSKQQWRKLDSAEV-VQVSRICGMYYAALNTLSQMKLDILTGICY-SD 499
            |.|::.|      ..|...:...:||...|| |.:..:..:|...|:. .:::...|..:.| |.
Zfish   190 EASASSG------DGSSHGENNVQKLGPVEVSVDIDAVRRVYDRLLSN-EKIEAAFLNALVYLSP 247

  Fly   500 NVLYDI-WLLITSLGPNCGMKEYLE---LLKSETNLQKPQTAMLML--FCDCMTH---------- 548
            ||..|: :..:.:..||     ||.   ::...:||..|:...:.|  ||..|:.
Zfish   248 NVECDLTYHNVYAADPN-----YLNVFIIVMENSNLHSPEYLEIALPQFCKAMSKLPLPALAKLA 307

  Fly   549 -----------------------YVTILDEHEMYTEQNPFKLNDYVL-------LTYFLNNILYK 583
                                   |..|.:|   ::..|....:|.|:       :.|:.|.:...
Zfish   308 RLWSQYGVDQIRRLVETFQQLITYTVISNE---FSSDNLVNEDDGVVAATKCLKIVYYANVLGGD 369

  Fly   584 LINDN-------------------LLAGAKNIVQHPVFLSLHTLMLCLYRRDCRRPFTP------ 623
            |..|:                   ||...:...:.|....|.|.| .:...|||:|..|
Zfish   370 LDTDHNEEDDDEPIPESSELTLQELLGEERRNKKGPRVDPLETEM-GIRASDCRKPLIPFEEFIN 433

  Fly   624 -PKHWLIPEVKPSTFINDLEKAKRNAM----LLLAKMPHI-IPHEDRVKLFRKFVQNEKAVMGLT 682
             |.:.::...|..||.....::|.:.|    :|.|...:: :.:::|::::.:  :...|:..|.
Zfish   434 EPLNEVLEMDKDYTFFKVETESKFSFMTCPFILNAVTKNLGLYYDNRIRMYSE--RRITALYSLV 496

  Fly   683 ESACASPRSALIVIHRDRIVEDG---YRQLAAQPTQALKGVIRVRFINQQGLHEAGIDQDGVFKE 744
            :....:|...| .:.||.|::|.   ...:|.:....||..:.|.|..:|     |:|:.||.||
Zfish   497 QGQQLNPYLRL-KVRRDHIIDDALVRLEMIAMENPADLKKQLYVEFEGEQ-----GVDEGGVSKE 555

  Fly   745 FLEETIKKVFDPSLNLFKTTSDQRLY-PSPISYVQDNHLELFEFVGRMLGKAVYEGIVVDVPFAS 808
            |.:..::::|:|.:.:|......:|: .:|.|:..:..   |..:|.:||.|:|...::||.|..
Zfish   556 FFQLVVEEIFNPDIGMFTYDESTKLFWFNPSSFENEGQ---FTLIGIVLGLAIYNNCILDVHFPM 617

  Fly   809 FFLSQLLGQTQQALYSCMDELPSLDNELYRSLTFIKHYKQDV-SDLNLTFSVDQ-DVMGKIVTLA 871
            ....:|:|:.     ....:|......|::||..:..|:.:| .|:.:||.:.| |:.|..:...
Zfish   618 VIYRKLMGKK-----GTFRDLADSHPVLFQSLKDLMEYEGNVEEDMMITFQISQTDLFGNPLMYD 677

  Fly   872 L-HPGGKARVVNDHNK---LVYIHYMAFFHMNTQIREQTIAFNRGFRSIVNPEWLS-LFSPPELQ 931
            | ..|.|..|.|::.|   .:|..||    :|..:.:|..||.|||..:.|...|. ||.|.|::
Zfish   678 LKESGDKIPVTNENRKDFVALYAEYM----LNKSVEKQFKAFRRGFHMVTNESPLKYLFRPEEIE 738

  Fly   932 RLISGDTSPLDLKDLQKHTHYYGGFHDTHQVVCWLWDILAKDFTEEERKLFLKFVTSCSKPPLLG 996
            .||.|..: ||.:.|::.|.|.||::...:::...|:.: ..|.:|:::|||:|.|...:.|:.|
Zfish   739 LLICGSRN-LDFQALEESTEYDGGYNKDSRIIRDFWETV-HSFEQEKKRLFLQFTTGTDRAPVGG 801

  Fly   997 FAHLEPPFSIRCVEVSDDEDTGDTIGSVIRGFFAIRKKDP-LNRLPTSSTCFNLLKLPNYQKKST 1060
            ...|:                           ..|.|..| .:|||||.||||:|.||.|.....
Zfish   802 LGKLK---------------------------MIIAKNGPDSDRLPTSHTCFNVLLLPEYSTVEK 839

  Fly  1061 LRDKLRYAVSSNTGF 1075
            |:::|..|::...||
Zfish   840 LKERLLKAITYAKGF 854

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5087	NP_648279.1	HECTc	694..1076	CDD:238033	110/394 (28%)
CG5087	NP_648279.1	HECTc	718..1075	CDD:214523	102/365 (28%)
ube3a	NP_001007319.1	AZUL	6..60	CDD:293166
		HECTc	505..855	CDD:238033	111/397 (28%)
		HECTc	532..854	CDD:214523	103/367 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810