DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5087 and Herc3

DIOPT Version :9

Sequence 1:	NP_648279.1	Gene:	CG5087 / 39035	FlyBaseID:	FBgn0035953	Length:	1078	Species:	Drosophila melanogaster
Sequence 2:	NP_001348895.1	Gene:	Herc3 / 73998	MGIID:	1921248	Length:	1050	Species:	Mus musculus

Alignment Length:	991	Identity:	235/991 - (23%)
Similarity:	384/991 - (38%)	Gaps:	242/991 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   241 CLRPLIDGNF---SRN------LLAKFLSEILSVPALIYHLQQSVPQCLEQFSSMGLLKKALSIS 296
            ||....||.|   .:|      |..:|.|:  :.|..:..| :.:|  |.|.::.|....|||:|
Mouse   149 CLALAADGQFFTWGKNSHGQLGLGKEFPSQ--TSPQRVRSL-EGIP--LAQVAAGGAHSFALSLS 208

  Fly   297 GDVQWFEEFGTSMP--------------------------------GTKSLAFLGNIVNLFNIDG 329
            |.|     ||..|.                                |.:..|.|.....:|.. |
Mouse   209 GAV-----FGWGMNNAGQLGLSDEKDRESPCHVKLLRTQKVVYISCGEEHTAVLTKSGGVFTF-G 267

  Fly   330 QGESKELAYPLLTETTT--SLLELIPNTVTTKGVFTQWHEL-------------------LG-WH 372
            .|...:|.:..:.:...  .:|||:.:.||......| |.|                   || .|
Mouse   268 AGSCGQLGHDSVNDEVNPRRVLELMGSEVTQIACGRQ-HTLALVPSSGLIYAFGCGAKGQLGTGH 331

  Fly   373 T-----PGPE----PAQNQNVALIKKQFHMLWDHRCIKLLL--GDLLKQINLNYER----IEFQS 422
            |     |.|.    .|.:..::....:|    .:|.:|.:.  ||....:...||.    ::|::
Mouse   332 TCNVKCPSPVKGHWAAHSSQLSARADRF----KYRVVKQIFSGGDQTFVLCSTYENSSPAVDFRT 392

  Fly   423 PQQPSISNLL---------RRALERSSTRGVNLMGVASSKQSKQQW------RKLDSAEVVQVS- 471
            ..|...:||:         ::..|.::...||  ||.....|...|      :|:|  |..:.|
Mouse   393 VNQTHYTNLINDETIAVWRQKLTEHNNANTVN--GVVQILSSAACWNGSFLEKKID--EHFKTSP 453

  Fly   472 RICGMYYAALNTL------SQMKLDILTGICYSDNVLYDIWLL--ITSLGPNC-GMKEYLELLKS 527
            :|.|:...:...|      ||..: ||..|..|    ::..|:  ::|..|:. .|:.||.|
Mouse   454 KIPGIDLNSTRILFEKLMHSQHSM-ILEQILNS----FESCLIPQLSSSPPDVEAMRIYLIL--- 510

  Fly   528 ETNLQKPQTAMLMLFCDCMTHYVTI---LDEHEMYTEQNPFKLND-----------YVLLTYFLN 578
                  |:..:|    ....:|:|:   |....:..|.||.|:.|           ..|:|.:..
Mouse   511 ------PEFPLL----QDSKYYITLTIPLAMAILRLETNPSKVLDNWWSQACPKYFMKLVTLYKG 565

  Fly   579 NILYKLINDNLLAGAKNIVQHPVFLSLHT----LMLCLYRRDCRRPFTPPKHWLIPEVKPSTFIN 639
            .:||      ||.|.|..:...:|.:..|    |:..||:.:.:........:.|||:  |:.::
Mouse   566 AVLY------LLRGRKTFLIPVLFNNYMTATLKLLEKLYKVNLKVKHVEYDKFYIPEI--SSLVD 622

  Fly   640 DLE------------KAKRNAM---LLLAKMPHIIPHEDRVKLFR--KFVQNEKAVMG------- 680
            ..|            ||:.:.|   :.|...|.|...:.:.|:.:  ..:|.:.||.|
Mouse   623 IQEDYLMWFLHQSGMKARPSIMQDAVTLCSYPFIFDAQAKTKMLQTDAELQMQVAVNGANLQNVF 687

  Fly   681 --LT-ESACASPRSALIVIH--RDRIVEDGYRQLAAQPTQALKGVIRVRFINQQGLHEAGIDQDG 740
              || |...|  ||..:|:|  |:.:|.|..|:|:......||..::|.|..     |.|:|..|
Mouse   688 MLLTLEPLLA--RSPFLVLHVRRNHLVGDALRELSIHSDIDLKKPLKVIFDG-----EEGVDAGG 745

  Fly   741 VFKEFLEETIKKVFDPSLNLFKTTSDQR-LYPSPISYVQDNHLELFEFVGRMLGKAVYEGIVVDV 804
            |.|||....:|::.:|...:|....|.. |:.|...:|:.|   .|..:|...|.|:|...|||:
Mouse   746 VTKEFFLLLLKELLNPIYGMFTYYQDSNLLWFSDTCFVEHN---WFHLIGITCGLAIYNSTVVDL 807

  Fly   805 PFASFFLSQLLGQTQQALYSCMDELPSLDNELYRSLTFIKHYK-QDVSD-LNLTFSVDQDVMGKI 867
            .|......:||.     :...:::|..|.....|||..:..|. :|:.: ..|.|:|.::..|.|
Mouse   808 HFPLALYKKLLN-----VKPSLEDLKELSPTEGRSLQELLDYPGEDIEETFCLNFTVCRESYGVI 867

  Fly   868 VTLALHPGGKARVVNDHNKLVYIHYMAFFHMNTQIREQTIAFNRGFRSIVNPEWLSLFSPPELQR 932
            ....|.|||....|...|:..::.....:.....:.|...||:.||..:...:.|.||.|.||:.
Mouse   868 EQKKLIPGGDRVAVCKDNRQEFVDAYVNYIFQISVHEWYTAFSSGFLKVCGGKVLELFQPAELRA 932

  Fly   933 LISGDTSPLDLKDLQKHTHYYGGFHDTHQVVCWLWDILAKDFTEEERKLFLKFVTSCSKPPLLGF 997
            ::.|: |..|.::|::...|.|.:..||..|...|:.. .:|..|::|.||.|:|...:.|:.|.
Mouse   933 MMVGN-SNYDWEELEETAVYRGDYSSTHPTVKLFWETF-HEFPLEKKKKFLLFLTGSDRIPIYGM 995

  Fly   998 AHLEPPFSIRCVEVSDDEDTGDTIGSVIRGFFAIRKKDPLNRLPTSSTCFNLLKLPNYQKKSTLR 1062
            |.|:        .:.....||:                  ..||.:.||:|||.||.|..|..::
Mouse   996 ASLQ--------IIIQSTATGE------------------EYLPVAHTCYNLLDLPKYSSKEIMK 1034

  Fly  1063 DKLRYAVSSNTGFELS 1078
            .:|..|:.:..||.|:
Mouse  1035 ARLTQALDNYEGFSLA 1050

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5087	NP_648279.1	HECTc	694..1076	CDD:238033	104/386 (27%)
CG5087	NP_648279.1	HECTc	718..1075	CDD:214523	95/359 (26%)
Herc3	NP_001348895.1	ATS1	2..331	CDD:227511	41/193 (21%)
		RCC1	313..377	CDD:366085	12/67 (18%)
		HECTc	702..1048	CDD:238033	104/386 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900