Protein Alignment CG5087 and hace1

DIOPT Version :10

• Sequence 1: NP_648279.1
• Gene: CG5087 / 39035
• FlyBaseID: FBgn0035953
• Length: 1078
• Species: Drosophila melanogaster
• Sequence 2: XP_012818577.2
• Gene: hace1 / 734146
• XenbaseID: XB-GENE-5757512
• Length: 1012
• Species: Xenopus tropicalis
• Alignment Length: 1162
• Identity: 256/1162 - (22%)
• Similarity: 423/1162 - (36%)
• Gaps: 392/1162 - (33%)

  Fly    78 YPVLRRYLTQIRLDKSDVRARERLERICRYIIKA----MESENTKLSYAALCLFKERSLPWIAHI 138
            ||.|.|.          .||.|:|.|:.|.:.:|    :..:|....|
 Frog    63 YPGLPRM----------ERAMEQLNRLTRSLRRARTVELPEDNETAVY----------------- 100

  Fly   139 KILLTNCLTLLPELKPENHADSLSLALFLHTLVVFTAPKSWAILRNAQFEKLQPAMQKICCNIQG 203
                    ||:|.:..:.|...|.|                  |.|::|:
 Frog   101 --------TLMPMVMADQHRSVLEL------------------LSNSKFD--------------- 124

  Fly   204 HLVQHDFYKIMRLVL-IRGTVREELSVKPVTLVAIITLCLRPLIDGNF------------SRNLL 255
              |.:.|.::.|.:| |......         |..:.|.|:...|.|:            :||..
 Frog   125 --VNYAFGRVKRSLLHIAANCGS---------VECLVLLLKRGADPNYQDISGCTPLHLAARNGQ 178

  Fly   256 AKFLSEILSVPA-----------------------LIYHLQQSVPQCLEQFSSMGLLKKALSISG 297
            .|.:|::|...|                       |::.|.|.|.. ::...:||  :.||.::
 Frog   179 KKCMSKLLEYNADVNICNNEGLTAIHWLAVNGRTELLHDLVQHVTN-VDVEDAMG--QTALHVA- 239

  Fly   298 DVQWFEEFGTSMPGTKS--LAFL--GNIVNLFNIDGQGESKELAYPLL-------TETTTSLL-- 349
                      ...|.|:  |..|  |..:|..|:.|       |.||.       .:|...||
 Frog   240 ----------CQNGHKTTVLCLLDSGADINRPNVSG-------ATPLYFACSHGQRDTAQILLLR 287

  Fly   350 --ELIP--NTVT-----TKGVFTQWHELLGWHTPGPEPA---QNQNVALIKKQFHMLWDH----- 397
              :.:|  |.||     .:|.:.:..::|..|.|.....   ..||..|.:.....:.:|
 Frog   288 GAKYLPDKNGVTPLDLCVQGGYGETCDILIQHHPRLFQTLIQMTQNEDLRENTLRQVLEHLSQQS 352

  Fly   398 --RCIKLLLGDLLKQINLN-YERIEFQSPQQPSISNLLRRA--------LERSSTRGVNLMGVAS 451
              :.:|:|.| |.:....| ::.:...|..:..:.:|||..        :..||....|.||...
 Frog   353 EVQYLKILTG-LAEVATTNGHKLLSISSSYEAQMKSLLRIVRIFCHVFRIGPSSPNNGNDMGYNG 416

  Fly   452 SKQSKQQ----------WRKLDSAEVVQVSRICGMYYAALNTLSQMKLDILTGICYSDNVLYDIW 506
            :|..:.|          :||::..|:...:..  :.|.|  |..|..|::|   .:|    .|.|
 Frog   417 NKTPRNQVFKVRNVYDVFRKINIKEMNLPNHT--LIYQA--TSEQDPLELL---WHS----LDEW 470

  Fly   507 LLI--TSLGPN--------CGMKEYLELLKSETNL------------------------------ 531
            |::  |.|..|        |.:.:..:|.:.:.:|
 Frog   471 LVLIATELTKNKRDSSNIACILLKQNQLDQQDISLAHQSAIGESGSYDHLSSSTRAEDFESCSAA 535

  Fly   532 --QKP--------------QTAMLMLF---CDC-----MT--HYVTILDEHE----MYTEQNPFK 566
              |:|              .:|::..|   |.|     ||  .::..:.:|:    .:..:||
 Frog   536 GKQEPVADGQDVISMTANRLSAVIQAFYMCCSCQMPQGMTSPRFIEFVCKHDDVLKCFVTRNP-- 598

  Fly   567 LNDYVLLTYFLNNILYKLINDNLLAGAKNIVQHPVFLSLHTLMLCLYRRDCRRPFTPPKHWLIPE 631
                            |:|.|:                .|.|:.|                  ||
 Frog   599 ----------------KIIFDH----------------FHFLLEC------------------PE 613

  Fly   632 VKPSTFINDLEKAKRNAMLLLAKMPHII---PHEDRVKLFRKFVQNEKAVMGLTESACAS---PR 690
                               |:::..|||   |.::|.:.|     .|..:.|..:|....   ..
 Frog   614 -------------------LMSRFMHIIKAQPFKERCEWF-----YEHLLAGQPDSDMVHRPVNE 654

  Fly   691 SALIVIHRDRIVEDGYRQLAAQPTQALKGVIRVRFINQQGLHEAGIDQDGVFKEFLEETIKKVFD 755
            :.::::|||.|.......:.....:.||..|.|||..::|:.:      ||.:|:.:....::.:
 Frog   655 NDILLVHRDSIFRSSCEVVFKSNCEKLKQGIAVRFHGEEGMGQ------GVVREWFDILSSEIIN 713

  Fly   756 PSLNLFKTTSDQRLY-PSPISYVQDNHLELFEFVGRMLGKAVYEGIVVDVPFASFFLSQLLGQTQ 819
            |...||..::|...: |:..|.|..:||..|.|.|.:||.|:|...:|::.|...|...:||
 Frog   714 PDYALFTQSADGTTFQPNSNSSVNPDHLNYFRFAGEILGLALYHRQLVNIYFTRSFYKHILG--- 775

  Fly   820 QALYSCMDELPSLDNELYRSLTFIKHYKQDVSD--LNLTFSVDQDVMGKIVTLALHPGGKARVVN 882
              :.....::.|:|.|..::|.:|  ...|:||  |.|||||:.||.|.:..:.|.|||.:.:|.
 Frog   776 --IPVNYQDVASIDPEYAKNLQWI--LDNDISDLGLELTFSVETDVFGAMEEVPLKPGGASILVT 836

  Fly   883 DHNKLVYIHYMAFFHMNTQIREQTIAFNRGFRSIVNPEWLSLFSPPELQRLISGDTSPLDLKDLQ 947
            ..||..|:..:....|...|:.|...|.:||...:.|..:.||...||:.|:|| ...:|:.|..
 Frog   837 QENKAEYVQLVTELRMTRAIQPQINGFLQGFHMFIPPSLIQLFDEYELELLLSG-MPEIDVNDWM 900

  Fly   948 KHTHYYGGFHDTHQVVCWLWDILAKDFTEEERKLFLKFVTSCSKPPLLGFAHLEPPFSIRCVEVS 1012
            |:|.|..|:....||:.|.|::: ::.|:|||.|.|:|||..|:.|..|||::..
 Frog   901 KNTEYTSGYERDDQVIQWFWEVV-QELTQEERVLLLQFVTGSSRVPHGGFAYIMG---------- 954

  Fly  1013 DDEDTGDTIGSVIRGFFAIRKKDPLNRLPTSSTCFNLLKLPNYQKKSTLRDKLRYAV 1069
                     ||.::.|.........|.|||||||.|:||||.|..|..|:|:|..|:
 Frog   955 ---------GSGLQNFTIAAVAYTPNLLPTSSTCINMLKLPEYPSKEILKDRLLVAL 1002

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG5087	NP_648279.1	IQCD	20..50	CDD:467745
		HECTc	694..1076	CDD:238033	120/379 (32%)
hace1	XP_012818577.2	ANKYR	66..317	CDD:440430	63/350 (18%)
		ANK repeat	134..163	CDD:293786	8/37 (22%)
		ANK repeat	165..196	CDD:293786	6/30 (20%)
		ANK repeat	198..229	CDD:293786	4/31 (13%)
		ANK repeat	231..262	CDD:293786	10/43 (23%)
		ANK repeat	264..289	CDD:293786	7/31 (23%)
		HECTc	657..1006	CDD:238033	120/380 (32%)