Protein Alignment CG5087 and UBE3A

DIOPT Version :10

• Sequence 1: NP_648279.1
• Gene: CG5087 / 39035
• FlyBaseID: FBgn0035953
• Length: 1078
• Species: Drosophila melanogaster
• Sequence 2: NP_000453.2
• Gene: UBE3A / 7337
• HGNCID: 12496
• Length: 875
• Species: Homo sapiens
• Alignment Length: 726
• Identity: 177/726 - (24%)
• Similarity: 310/726 - (42%)
• Gaps: 148/726 - (20%)

  Fly   437 ERSSTRGVNLMGVASSKQSKQQWRKLDSAEV-VQVSRICGMYYAALNTLSQMKLD--ILTGICY- 497
            |.||:|      :..|.|.....:||...:| |.:..|..:|   ...||..|::  .|..:.|
Human   208 EASSSR------IGDSSQGDNNLQKLGPDDVSVDIDAIRRVY---TRLLSNEKIETAFLNALVYL 263

  Fly   498 SDNVLYDI-WLLITSLGPNCGMKEYLEL---LKSETNLQKPQ--TAMLMLFCDCMTHYVTILDEH 556
            |.||..|: :..:.|..||     ||.|   :....||..|:  ...|.|||..|:.........
Human   264 SPNVECDLTYHNVYSRDPN-----YLNLFIIVMENRNLHSPEYLEMALPLFCKAMSKLPLAAQGK 323

  Fly   557 --EMYTEQNPFKLNDYVLLTYFLNNILYK----------LINDN--LLAGAK--------NIV-- 597
              .::::.|..::..  ::..|...|.||          |:||:  ::|.:|        |:|
Human   324 LIRLWSKYNADQIRR--MMETFQQLITYKVISNEFNSRNLVNDDDAIVAASKCLKMVYYANVVGG 386

  Fly   598 -----------QHPV----FLSLHTLM------------------LCLYRRDCRRPFTP------ 623
                       :.|:    .|:|..|:                  |.:...|||:|..|
Human   387 EVDTNHNEEDDEEPIPESSELTLQELLGEERRNKKGPRVDPLETELGVKTLDCRKPLIPFEEFIN 451

  Fly   624 -PKHWLIPEVKPSTFINDLEKAKRNAM----LLLAKMPHI-IPHEDRVKLFRKFVQNEKAVMGLT 682
             |.:.::...|..||.....:.|.:.|    :|.|...:: :.:::|::::.:  :....:..|.
Human   452 EPLNEVLEMDKDYTFFKVETENKFSFMTCPFILNAVTKNLGLYYDNRIRMYSE--RRITVLYSLV 514

  Fly   683 ESACASPRSALIVIHRDRIVEDG---YRQLAAQPTQALKGVIRVRFINQQGLHEAGIDQDGVFKE 744
            :....:|...| .:.||.|::|.   ...:|.:....||..:.|.|..:|     |:|:.||.||
Human   515 QGQQLNPYLRL-KVRRDHIIDDALVRLEMIAMENPADLKKQLYVEFEGEQ-----GVDEGGVSKE 573

  Fly   745 FLEETIKKVFDPSLNLFKTTSDQRLY-PSPISYVQDNHLELFEFVGRMLGKAVYEGIVVDVPFAS 808
            |.:..::::|:|.:.:|......:|: .:|.|:..:..   |..:|.:||.|:|...::||.|..
Human   574 FFQLVVEEIFNPDIGMFTYDESTKLFWFNPSSFETEGQ---FTLIGIVLGLAIYNNCILDVHFPM 635

  Fly   809 FFLSQLLGQTQQALYSCMDELPSLDNELYRSLTFIKHYKQDV-SDLNLTFSVDQ-DVMGKIVTLA 871
            ....:|:|:.     ....:|......||:||..:..|:.:| .|:.:||.:.| |:.|..:...
Human   636 VVYRKLMGKK-----GTFRDLGDSHPVLYQSLKDLLEYEGNVEDDMMITFQISQTDLFGNPMMYD 695

  Fly   872 LHPGGKARVVNDHNKLVYIHYMAFFHMNTQIREQTIAFNRGFRSIVNPEWLS-LFSPPELQRLIS 935
            |...|....:.:.|:..:::..:.:.:|..:.:|..||.|||..:.|...|. ||.|.|::.||.
Human   696 LKENGDKIPITNENRKEFVNLYSDYILNKSVEKQFKAFRRGFHMVTNESPLKYLFRPEEIELLIC 760

  Fly   936 GDTSPLDLKDLQKHTHYYGGFHDTHQVVCWLWDILAKDFTEEERKLFLKFVTSCSKPPLLGFAHL 1000
            |..: ||.:.|::.|.|.||:.....::...|:|: ..||:|:::|||:|.|...:.|:.|...|
Human   761 GSRN-LDFQALEETTEYDGGYTRDSVLIREFWEIV-HSFTDEQKRLFLQFTTGTDRAPVGGLGKL 823

  Fly  1001 EPPFSIRCVEVSDDEDTGDTIGSVIRGFFAIRKKDP-LNRLPTSSTCFNLLKLPNYQKKSTLRDK 1064
            :                           ..|.|..| ..|||||.||||:|.||.|..|..|:::
Human   824 K---------------------------MIIAKNGPDTERLPTSHTCFNVLLLPEYSSKEKLKER 861

  Fly  1065 LRYAVSSNTGF 1075
            |..|::...||
Human   862 LLKAITYAKGF 872

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG5087	NP_648279.1	IQCD	20..50	CDD:467745
		HECTc	694..1076	CDD:238033	108/390 (28%)
UBE3A	NP_000453.2	AZUL	29..83	CDD:465173
		HECTc	523..873	CDD:238033	109/393 (28%)