DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5087 and Ubr5

DIOPT Version :9

Sequence 1:	NP_648279.1	Gene:	CG5087 / 39035	FlyBaseID:	FBgn0035953	Length:	1078	Species:	Drosophila melanogaster
Sequence 2:	XP_006520242.1	Gene:	Ubr5 / 70790	MGIID:	1918040	Length:	2800	Species:	Mus musculus

Alignment Length:	1231	Identity:	232/1231 - (18%)
Similarity:	382/1231 - (31%)	Gaps:	464/1231 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 AQNQKASFLEQTKAAREE---RALEKRREQAAILLQSTLKGYAARRKYQKRIILDFDAMFTENHD 64
            :||   |...:...||||   |.||.||.  |.||.:.....:||..:     |::......:|:
Mouse  1875 SQN---SARRERMTAREEASLRTLEGRRR--ATLLSARQGMMSARGDF-----LNYALSLMRSHN 1929

  Fly    65 DKDAELELVASNVYPVLRRYLTQIRLDKSDVRARERLERICR---YIIKAMESENTKLSYAALCL 126
            |:.       |:|.|||            ||.:.:.:..:.:   |.|||| ::.|.|....|..
Mouse  1930 DEH-------SDVLPVL------------DVCSLKHVAYVFQALIYWIKAM-NQQTTLDTPQLER 1974

  Fly   127 FKERSLPWIAHIKILLTN-------------CLTL-------LPELKPENH-----ADSLSLALF 166
            .:.|.|     :::.:.|             ..||       ||....:||     :||::   |
Mouse  1975 KRTREL-----LELGIDNEDSEHENDDDTSQSATLNDKDDDSLPAETGQNHPFFRRSDSMT---F 2031

  Fly   167 LHTLVVFTAPKSWAILRNAQFEKLQPAMQKICCNIQGHLVQHDFYKIMRLVLIRGTVREELSVKP 231
            |..:    .|..:.:          |..:.|....|.||:|.:..|            |:|..:|
Mouse  2032 LGCI----PPNPFEV----------PLAEAIPLADQPHLLQPNARK------------EDLFGRP 2070

  Fly   232 VTLVAIITLCLRPLIDGNFSRNLLAKFLSEILSVPALIYHLQQSVPQCLEQFSSMGLLKKALSIS 296
                               |:.|.:                           ||.|..|..:.::
Mouse  2071 -------------------SQGLYS---------------------------SSAGSGKCIVEVT 2089

  Fly   297 GDVQWFEEFGTSMPGTKSLAFLGNIVNLFNIDGQGESKELAYPLLTETTTSLLELIPNTVTTKGV 361
            .|....|...|.|      ::..|:.|:.|:..:.:.:.....||.|...|
Mouse  2090 MDRNCLEVLPTKM------SYAANLKNVMNMQNRQKKEGEEQSLLAEEADS-------------- 2134

  Fly   362 FTQWHELLGWHTPGPEPAQNQNVALIKKQFHMLWDHRCIKLLLGDLLKQINLNYERIEFQSPQ-- 424
                      ..|||..   .:||               ..|...||.:|.|.    |.:.|.
Mouse  2135 ----------SKPGPSA---PDVA---------------AQLKSSLLAEIGLT----ESEGPPLT 2167

  Fly   425 --QPSISNLLRRALERSSTRGVNLMGVASSKQSKQQWRKLDSAEVVQVSRICGMYYAALNTLSQM 487
              :|..|                .||:                 |:....:.|.:..:|.
Mouse  2168 SFRPQCS----------------FMGM-----------------VISHDMLLGRWRLSLE----- 2194

  Fly   488 KLDILTGICYSDNVLYDIWLLITSLGPNCGMKEYLELLKSETNLQKPQTAMLMLFCDCMTHYVTI 552
                |.|..:.::|..:...::|.|| ...:|| .:..:....|:..|:..|.|       .|.:
Mouse  2195 ----LFGRVFMEDVGAEPGSILTELG-GFEVKE-SKFRREMEKLRNQQSRDLSL-------EVKV 2246

  Fly   553 LDEHEMYTEQNPFKLNDY--------------VLLTY---------------------FLNNILY 582
            ..:.::..:|...:||::              |.:|:                     ||:|  .
Mouse  2247 DRDRDLLIQQTMRQLNNHFGRRCATTPMAVHRVKVTFKDEPGEGSGVARSFYTAIAQAFLSN--E 2309

  Fly   583 KLINDNLLAGAKNIVQHPVFLSLHTLMLCLYR------------------------------RDC 617
            ||.|.:.:..|..        ..||.::...|                              ||.
Mouse  2310 KLPNLDCIQNANK--------GTHTSLMQRLRNRGERDREREREREMRRSSGLRAGSRRDRDRDF 2366

  Fly   618 R-------RPFTP-------------PKH------WLIPEVK--PSTFIND-----LEKAKRNAM 649
            |       |||.|             |.|      .|.|.|:  ...|.:.     ||.:....:
Mouse  2367 RRQLSIDTRPFRPASEGNPSDDPDPLPAHRQALGERLYPRVQAMQPAFASKITGMLLELSPAQLL 2431

  Fly   650 LLLAKMPHIIPHEDRVKLFRKFVQNEKAVMGLTESACASPRSALIVIH-----RDRIVEDGYRQL 709
            ||||.       ||.::                  |.......||:.|     .|.|::.|....
Mouse  2432 LLLAS-------EDSLR------------------ARVDEAMELIIAHGRENGADSILDLGLLDS 2471

  Fly   710 AAQPTQALKGVIRVRFINQQGLHEAGIDQDGVFKEFLEETIKKVFDPSLNLFKTTSDQRLYPSPI 774
            :.:..:..|         :.|...:.:|.|      ||:|...  |.:..||.....:..|....
Mouse  2472 SEKVQENRK---------RHGSSRSVVDMD------LEDTDDG--DDNAPLFYQPGKRGFYTPRP 2519

  Fly   775 SYVQDNHLELFEFVGRMLGKAVYEGIVVDVPFASFFLSQLLGQTQQALYSCMDELPSLDNELYRS 839
            ....:..|..|..:||:||..:.:..:..:......:..|||:...     ..:....|..:|.|
Mouse  2520 GKNTEARLNCFRNIGRILGLCLLQNELCPITLNRHVIKVLLGRKVN-----WHDFAFFDPVMYES 2579

  Fly   840 L--TFIKHYKQDV----SDLNLTFSVD---QDVMGKIVTLALHPGGKARVVNDHNKLVYIHYMAF 895
            |  ..:.....|.    |.::|.|::|   ::..|::   .|.|.|....|...|...|:...|.
Mouse  2580 LRQLILASQSSDADAVFSAMDLAFAIDLCKEEGGGQV---ELIPNGVNIPVTPQNVYEYVRKYAE 2641

  Fly   896 FHMNTQIREQTIAFNRGFRSIVNPEWLSLFSPPELQRLISGDTSPLDLKDLQKHTHYYGGFHDTH 960
            ..|.....:...|..:|...::....|...:..:.:.|::| ...::::.|...|    .|:|..
Mouse  2642 HRMLVVAEQPLHAMRKGLLDVLPKNSLEDLTAEDFRLLVNG-CGEVNVQMLISFT----SFNDES 2701

  Fly   961 --------QVVCWLWDILAKDFTEEERKLFLKFVTSCSKPPLL--GFAHLEPPFSIRCVEVSDDE 1015
                    |...|.|.|:.| .:..||:..:.|.||....|..  ||..: |..:||   ..||:
Mouse  2702 GENAEKLLQFKRWFWSIVEK-MSMTERQDLVYFWTSSPSLPASEEGFQPM-PSITIR---PPDDQ 2761

  Fly  1016 DTGDTIGSVIRGFFAIRKKDPLNRLPTSSTCFNLLKLPNYQKKSTLRDKLRYAV-SSNTGF 1075
                                   .|||::||.:.|.:|.|..|..|:.||..|: :.|.||
Mouse  2762 -----------------------HLPTANTCISRLYVPLYSSKQILKQKLLLAIKTKNFGF 2799

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5087	NP_648279.1	HECTc	694..1076	CDD:238033	86/407 (21%)
CG5087	NP_648279.1	HECTc	718..1075	CDD:214523	79/376 (21%)
Ubr5	XP_006520242.1	CUE_UBR5	184..230	CDD:270606
		ZnF_UBR1	1177..1244	CDD:197698
		PolyA	2391..2454	CDD:197769	17/87 (20%)
		HECTc	2469..2797	CDD:214523	78/385 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900