DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5087 and Ube3b

DIOPT Version :9

Sequence 1:	NP_648279.1	Gene:	CG5087 / 39035	FlyBaseID:	FBgn0035953	Length:	1078	Species:	Drosophila melanogaster
Sequence 2:	NP_001137366.1	Gene:	Ube3b / 687633	RGDID:	1583074	Length:	1070	Species:	Rattus norvegicus

Alignment Length:	1097	Identity:	524/1097 - (47%)
Similarity:	714/1097 - (65%)	Gaps:	46/1097 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MF--AQNQKASFLEQTKAAREERALEKRREQAAILLQSTLKGYAARRKYQKRIILDFDAMFTENH 63
            ||  :|..:|.||::.:.|||||..:|.||::|:|:|:.::.:..||:..|.:..:.|..||.
  Rat     1 MFTVSQTSRAWFLDKARQAREERLEQKERERSAVLIQALVRSFLCRRRLHKDVRREIDEFFTA-- 63

  Fly    64 DDKDAELELVASNVYPVLRRYLTQIRLDKSDVRARERLERICRYIIKAMESEN-TKLSYAALCLF 127
             |:....:..|..::.:.|:.|...:..:.:    ||:|::||.|:.:|::|| .|:.|.:|.|.
  Rat    64 -DESGSSKRSALCIFKIARKLLFICKTTEDN----ERMEKLCRSILSSMDAENEPKVWYVSLALS 123

  Fly   128 KERSLPWIAHIKILLTNCLTLLPELKPENHADSLSLALFLHTLVVFTAPKSWAILRNAQFEKLQP 192
            |:.:|.||..||.:|..|..||.:||||...||..:.|:|..||.||...:|.||| .:.|.|:|
  Rat   124 KDLTLLWIKQIKSILWYCCELLGQLKPEILQDSRLITLYLTMLVTFTDTSTWKILR-GKGESLRP 187

  Fly   193 AMQKICCNIQGHLVQHDFYKIMRLVLIRGTVREELSVKPVTLVAIITLCLRPLIDGNFSRNLLAK 257
            |:..||.||.|||.|..||.:::::|.||..|....:...||.|..||.|||::...||.:|:..
  Rat   188 ALNHICANIMGHLNQRGFYSVLQVLLTRGLARPRPCLSKSTLTAAFTLALRPVVAAQFSDSLMRP 252

  Fly   258 FLSEILSVPALIYHLQQSVPQCLEQFSSMGLLKKALSISGDVQWFEEFGTSMPGTKSLAFLGNIV 322
            |:..|:|||||:.||....|:.|....|..:|:|.:....|....::...|:.|..:|..:||::
  Rat   253 FIIHIMSVPALVAHLSTMAPERLGVLESHDMLRKFIVFLRDRDRCQDACESLEGCHTLCLMGNLL 317

  Fly   323 NLFNIDGQGESKELAYPLLTETTTSLLELIPNTV--------TTKGVFTQWHELLGWHTPGPEPA 379
            :|.:::         ..:|.|.|...:.|:...:        ..|...|.||.:|||.:...:..
  Rat   318 HLGSLN---------LKMLEEETDGFVSLLTQMLCYCQKYVSQKKSNLTHWHPVLGWFSQSVDYG 373

  Fly   380 QNQNVALIKKQFHMLWDHRCIKLLLGDLL-KQINLNYERIEFQ-SPQQPS----ISNLLRRALER 438
            .|.::.||.||...||....|::...|:| |::....|.:..| .|..|.    :.:||:||.::
  Rat   374 LNDSMYLITKQLQFLWGVPLIRIFFSDILSKKLLEPPEPVPAQPQPSSPQTVLPVKSLLKRAFQK 438

  Fly   439 S-STRGVNLMGVASSKQSKQQWRKLDSAEVVQVSRICGMYYAALNTLSQMKLDILTGICYSDNVL 502
            | |.|.: |..|..        |::||.||.:|..||.:|..:|.||:|::|.||||:.|.|::|
  Rat   439 SASVRNI-LKPVGG--------RRVDSTEVRKVCSICVLYQTSLTTLTQIRLQILTGLTYLDDLL 494

  Fly   503 YDIWLLITSLGPNCGMKEYLELLKSETNLQKPQTAMLMLFCDCMTHYVTILDEHEMYTEQNPFKL 567
            ..:|..|..|||:.|:|.:||.|.::|...|...|||||||||..|.:||||:.|:|.||..|||
  Rat   495 PKLWAFICELGPHGGLKLFLECLNNDTGESKQLLAMLMLFCDCSRHLITILDDIEVYEEQISFKL 559

  Fly   568 NDYVLLTYFLNNILYKLINDNLLAGAKNIVQHPVFLSLHTLMLCLYRRDCRRPFTPPKHWLIPEV 632
            .:.|.::.|||:.::|:|.|.::..||..... :|.|:|..::.||.|||||.|.|..|||..::
  Rat   560 EELVTISSFLNSFVFKMIWDGIVENAKGETLE-LFQSVHGWLMVLYERDCRRRFAPEDHWLRKDL 623

  Fly   633 KPSTFINDLEKAKRNAMLLLAKMPHIIPHEDRVKLFRKFVQNEKAVMGLTESACASPRSALIVIH 697
            ||.....:|:|.::.|.|:|..:||::||::||.|||..|..||..:||.|::.|||....|.|.
  Rat   624 KPGVLFQELDKDRKRAQLILLHIPHVVPHKNRVLLFRNMVIKEKEKLGLVETSSASPHVTHITIR 688

  Fly   698 RDRIVEDGYRQLAAQPTQALKGVIRVRFINQQGLHEAGIDQDGVFKEFLEETIKKVFDPSLNLFK 762
            |.|::||||.||...|..|:||.|||:|::..|:.||||||||||||||||.||:||||:|||||
  Rat   689 RSRMLEDGYEQLRQLPQHAMKGAIRVKFVSDLGVDEAGIDQDGVFKEFLEEIIKRVFDPALNLFK 753

  Fly   763 TTS-DQRLYPSPISYVQDNHLELFEFVGRMLGKAVYEGIVVDVPFASFFLSQLLGQTQQALYSCM 826
            ||| |:||||||.||:.:|:|:||||||:|||||||||||||||||||||||:||......||.:
  Rat   754 TTSGDERLYPSPTSYIHENYLQLFEFVGKMLGKAVYEGIVVDVPFASFFLSQMLGHHHSVFYSSV 818

  Fly   827 DELPSLDNELYRSLTFIKHYKQDVSDLNLTFSVDQDVMGKIVTLALHPGGKARVVNDHNKLVYIH 891
            |||||||:|.|::||.||.|..||:||.||.|.|:||||::|...|.||||...|.|.||:.|||
  Rat   819 DELPSLDSEFYKNLTSIKRYDGDVADLGLTLSYDEDVMGQLVCHELVPGGKTIPVTDENKISYIH 883

  Fly   892 YMAFFHMNTQIREQTIAFNRGFRSIVNPEWLSLFSPPELQRLISGDTSPLDLKDLQKHTHYYGGF 956
            .||.|.|:|||:.||.|...|||||:.|||:.:||.||||||||||.:.:||:||:|||.|||||
  Rat   884 LMAHFRMHTQIKNQTAALISGFRSIIKPEWIRMFSTPELQRLISGDNAEIDLEDLKKHTVYYGGF 948

  Fly   957 HDTHQVVCWLWDILAKDFTEEERKLFLKFVTSCSKPPLLGFAHLEPPFSIRCVEVSDDEDTGDTI 1021
            |.:|:|:.|||||||.|||..||.:|||||||||:|||||||:|:|||||||||||||:|||||:
  Rat   949 HGSHRVIVWLWDILASDFTPGERAMFLKFVTSCSRPPLLGFAYLKPPFSIRCVEVSDDQDTGDTL 1013

  Fly  1022 GSVIRGFFAIRKKDPLNRLPTSSTCFNLLKLPNYQKKSTLRDKLRYAVSSNTGFELS 1078
            |||:||||.|||::|..|||||||||||||||||.|||.||:|||||:|.|||||||
  Rat  1014 GSVLRGFFTIRKREPGGRLPTSSTCFNLLKLPNYSKKSVLREKLRYAISMNTGFELS 1070

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5087	NP_648279.1	HECTc	694..1076	CDD:238033	266/382 (70%)
CG5087	NP_648279.1	HECTc	718..1075	CDD:214523	253/357 (71%)
Ube3b	NP_001137366.1	HECTc	684..1068	CDD:238033	266/383 (69%)
Ube3b	NP_001137366.1	HECTc	709..1067	CDD:214523	253/357 (71%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166344240
Domainoid	1	1.000	498	1.000	Domainoid score	I343
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H13775
Inparanoid	1	1.050	908	1.000	Inparanoid score	I352
OMA	1	1.010	-	-		QHG48068
OrthoDB	1	1.010	-	-		D1163565at2759
OrthoFinder	1	1.000	-	-		FOG0006345
OrthoInspector	1	1.000	-	-		oto95598
orthoMCL	1	0.900	-	-		OOG6_100865
Panther	1	1.100	-	-	LDO	PTHR45700
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X4619
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	15	14.810