Protein Alignment CG5087 and Ube3b

DIOPT Version :10

• Sequence 1: NP_648279.1
• Gene: CG5087 / 39035
• FlyBaseID: FBgn0035953
• Length: 1078
• Species: Drosophila melanogaster
• Sequence 2: NP_001137366.1
• Gene: Ube3b / 687633
• RGDID: 1583074
• Length: 1070
• Species: Rattus norvegicus
• Alignment Length: 1097
• Identity: 524/1097 - (47%)
• Similarity: 714/1097 - (65%)
• Gaps: 46/1097 - (4%)

  Fly     1 MF--AQNQKASFLEQTKAAREERALEKRREQAAILLQSTLKGYAARRKYQKRIILDFDAMFTENH 63
            ||  :|..:|.||::.:.|||||..:|.||::|:|:|:.::.:..||:..|.:..:.|..||.
  Rat     1 MFTVSQTSRAWFLDKARQAREERLEQKERERSAVLIQALVRSFLCRRRLHKDVRREIDEFFTA-- 63

  Fly    64 DDKDAELELVASNVYPVLRRYLTQIRLDKSDVRARERLERICRYIIKAMESEN-TKLSYAALCLF 127
             |:....:..|..::.:.|:.|...:..:.:    ||:|::||.|:.:|::|| .|:.|.:|.|.
  Rat    64 -DESGSSKRSALCIFKIARKLLFICKTTEDN----ERMEKLCRSILSSMDAENEPKVWYVSLALS 123

  Fly   128 KERSLPWIAHIKILLTNCLTLLPELKPENHADSLSLALFLHTLVVFTAPKSWAILRNAQFEKLQP 192
            |:.:|.||..||.:|..|..||.:||||...||..:.|:|..||.||...:|.||| .:.|.|:|
  Rat   124 KDLTLLWIKQIKSILWYCCELLGQLKPEILQDSRLITLYLTMLVTFTDTSTWKILR-GKGESLRP 187

  Fly   193 AMQKICCNIQGHLVQHDFYKIMRLVLIRGTVREELSVKPVTLVAIITLCLRPLIDGNFSRNLLAK 257
            |:..||.||.|||.|..||.:::::|.||..|....:...||.|..||.|||::...||.:|:..
  Rat   188 ALNHICANIMGHLNQRGFYSVLQVLLTRGLARPRPCLSKSTLTAAFTLALRPVVAAQFSDSLMRP 252

  Fly   258 FLSEILSVPALIYHLQQSVPQCLEQFSSMGLLKKALSISGDVQWFEEFGTSMPGTKSLAFLGNIV 322
            |:..|:|||||:.||....|:.|....|..:|:|.:....|....::...|:.|..:|..:||::
  Rat   253 FIIHIMSVPALVAHLSTMAPERLGVLESHDMLRKFIVFLRDRDRCQDACESLEGCHTLCLMGNLL 317

  Fly   323 NLFNIDGQGESKELAYPLLTETTTSLLELIPNTV--------TTKGVFTQWHELLGWHTPGPEPA 379
            :|.:::         ..:|.|.|...:.|:...:        ..|...|.||.:|||.:...:..
  Rat   318 HLGSLN---------LKMLEEETDGFVSLLTQMLCYCQKYVSQKKSNLTHWHPVLGWFSQSVDYG 373

  Fly   380 QNQNVALIKKQFHMLWDHRCIKLLLGDLL-KQINLNYERIEFQ-SPQQPS----ISNLLRRALER 438
            .|.::.||.||...||....|::...|:| |::....|.:..| .|..|.    :.:||:||.::
  Rat   374 LNDSMYLITKQLQFLWGVPLIRIFFSDILSKKLLEPPEPVPAQPQPSSPQTVLPVKSLLKRAFQK 438

  Fly   439 S-STRGVNLMGVASSKQSKQQWRKLDSAEVVQVSRICGMYYAALNTLSQMKLDILTGICYSDNVL 502
            | |.|.: |..|..        |::||.||.:|..||.:|..:|.||:|::|.||||:.|.|::|
  Rat   439 SASVRNI-LKPVGG--------RRVDSTEVRKVCSICVLYQTSLTTLTQIRLQILTGLTYLDDLL 494

  Fly   503 YDIWLLITSLGPNCGMKEYLELLKSETNLQKPQTAMLMLFCDCMTHYVTILDEHEMYTEQNPFKL 567
            ..:|..|..|||:.|:|.:||.|.::|...|...|||||||||..|.:||||:.|:|.||..|||
  Rat   495 PKLWAFICELGPHGGLKLFLECLNNDTGESKQLLAMLMLFCDCSRHLITILDDIEVYEEQISFKL 559

  Fly   568 NDYVLLTYFLNNILYKLINDNLLAGAKNIVQHPVFLSLHTLMLCLYRRDCRRPFTPPKHWLIPEV 632
            .:.|.::.|||:.::|:|.|.::..||..... :|.|:|..::.||.|||||.|.|..|||..::
  Rat   560 EELVTISSFLNSFVFKMIWDGIVENAKGETLE-LFQSVHGWLMVLYERDCRRRFAPEDHWLRKDL 623

  Fly   633 KPSTFINDLEKAKRNAMLLLAKMPHIIPHEDRVKLFRKFVQNEKAVMGLTESACASPRSALIVIH 697
            ||.....:|:|.::.|.|:|..:||::||::||.|||..|..||..:||.|::.|||....|.|.
  Rat   624 KPGVLFQELDKDRKRAQLILLHIPHVVPHKNRVLLFRNMVIKEKEKLGLVETSSASPHVTHITIR 688

  Fly   698 RDRIVEDGYRQLAAQPTQALKGVIRVRFINQQGLHEAGIDQDGVFKEFLEETIKKVFDPSLNLFK 762
            |.|::||||.||...|..|:||.|||:|::..|:.||||||||||||||||.||:||||:|||||
  Rat   689 RSRMLEDGYEQLRQLPQHAMKGAIRVKFVSDLGVDEAGIDQDGVFKEFLEEIIKRVFDPALNLFK 753

  Fly   763 TTS-DQRLYPSPISYVQDNHLELFEFVGRMLGKAVYEGIVVDVPFASFFLSQLLGQTQQALYSCM 826
            ||| |:||||||.||:.:|:|:||||||:|||||||||||||||||||||||:||......||.:
  Rat   754 TTSGDERLYPSPTSYIHENYLQLFEFVGKMLGKAVYEGIVVDVPFASFFLSQMLGHHHSVFYSSV 818

  Fly   827 DELPSLDNELYRSLTFIKHYKQDVSDLNLTFSVDQDVMGKIVTLALHPGGKARVVNDHNKLVYIH 891
            |||||||:|.|::||.||.|..||:||.||.|.|:||||::|...|.||||...|.|.||:.|||
  Rat   819 DELPSLDSEFYKNLTSIKRYDGDVADLGLTLSYDEDVMGQLVCHELVPGGKTIPVTDENKISYIH 883

  Fly   892 YMAFFHMNTQIREQTIAFNRGFRSIVNPEWLSLFSPPELQRLISGDTSPLDLKDLQKHTHYYGGF 956
            .||.|.|:|||:.||.|...|||||:.|||:.:||.||||||||||.:.:||:||:|||.|||||
  Rat   884 LMAHFRMHTQIKNQTAALISGFRSIIKPEWIRMFSTPELQRLISGDNAEIDLEDLKKHTVYYGGF 948

  Fly   957 HDTHQVVCWLWDILAKDFTEEERKLFLKFVTSCSKPPLLGFAHLEPPFSIRCVEVSDDEDTGDTI 1021
            |.:|:|:.|||||||.|||..||.:|||||||||:|||||||:|:|||||||||||||:|||||:
  Rat   949 HGSHRVIVWLWDILASDFTPGERAMFLKFVTSCSRPPLLGFAYLKPPFSIRCVEVSDDQDTGDTL 1013

  Fly  1022 GSVIRGFFAIRKKDPLNRLPTSSTCFNLLKLPNYQKKSTLRDKLRYAVSSNTGFELS 1078
            |||:||||.|||::|..|||||||||||||||||.|||.||:|||||:|.|||||||
  Rat  1014 GSVLRGFFTIRKREPGGRLPTSSTCFNLLKLPNYSKKSVLREKLRYAISMNTGFELS 1070

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG5087	NP_648279.1	IQCD	20..50	CDD:467745	10/29 (34%)
		HECTc	694..1076	CDD:238033	266/382 (70%)
Ube3b	NP_001137366.1	HECTc	684..1068	CDD:238033	266/383 (69%)