DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5087 and Arel1

DIOPT Version :9

Sequence 1:	NP_648279.1	Gene:	CG5087 / 39035	FlyBaseID:	FBgn0035953	Length:	1078	Species:	Drosophila melanogaster
Sequence 2:	NP_001351118.1	Gene:	Arel1 / 68497	MGIID:	1915747	Length:	823	Species:	Mus musculus

Alignment Length:	741	Identity:	170/741 - (22%)
Similarity:	292/741 - (39%)	Gaps:	194/741 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   417 RIEFQSPQQPSISNLLRRALERSSTRGVNLMGVASSKQSKQQWRK--LDSAEVVQV-------SR 472
            |.|:.:|...|:|  ||.  |.|.:..::.:|....:.::..:.|  ..:.:..||       ||
Mouse   192 RDEYDNPTNNSMS--LRD--EHSYSLAIHELGPQEEENNEVSFEKSVTSNRQTCQVFLRLTLHSR 252

  Fly   473 ICGMYYAALN--------------TLSQMKLDIL------TGI-CYSDNVLYDIWLLITSLGPNC 516
              |.::|.::              .||:.:.:|:      :|: .|.:..||:        ..||
Mouse   253 --GCFHACISYQNQPINNGEFDIIVLSENEKNIVERNVSTSGVSIYFEAYLYN--------ANNC 307

  Fly   517 -GMKEYLELLKSETNLQKPQTAMLMLFCDCMTHYVTILDEHEMYTE-------QNPFKLNDYV-- 571
             ....:|..:...::.::|.||:..             |:.:..:|       :.|.|:..||
Mouse   308 TSTPWHLPPMHMSSSQRRPSTAIEE-------------DDEDSPSECHTPEKVKKPKKVYCYVSP 359

  Fly   572 ----LLTYFLNNILYKLINDNLLAGAK------------------NIVQHPVFLSLHTLMLCLYR 614
                :..::|..|.::|....:..|.|                  :.:|.||.||      |..|
Mouse   360 KQFSVKEFYLKIIPWRLYTFRVCPGTKFSYLGPDPVHKLLTLVVDDGIQPPVELS------CKER 418

  Fly   615 RDCRRPFTPPKHWLIPEVKPSTFINDLEKAKRNAMLLLAKMPHIIPHEDRVKLFRKFVQNEKAVM 679
                            .:..:|||..|.|....:...          :|:|..|::
Mouse   419 ----------------NILAATFIRSLHKNIGGSETF----------QDKVNFFQR--------- 448

  Fly   680 GLTESACASPRSAL-IVIHRDRIVEDGYRQLAAQPTQALKGVIRVRFINQQGLHEAGIDQDGVFK 743
            .|.:.....|.|.: :.:.|..::|...:...............|.|.:::.|     |..|..:
Mouse   449 ELRQVHMKRPHSKVTLKVSRHALLESSLKATRNFSISDWSKNFEVVFQDEEAL-----DWGGPRR 508

  Fly   744 EFLEETIKKVFDPSLNLFK--TTSDQRL-YPSPISYVQDNHLEL--FEFVGRMLGKAVYEGI--- 800
            |:.|...|.:||.:..||.  |.|:|.| :|:|   .:..||.|  :||.||::||.:||..
Mouse   509 EWFELICKALFDTTSQLFARFTDSNQALVHPNP---NRPAHLRLKMYEFAGRLVGKCLYESSLGG 570

  Fly   801 ----VVDVPFASFFLSQLLGQTQQALYSCMDELPSLDNELYRS-LTFIKHYKQDVSDLNLTFSVD 860
                :|...|...||:|::|......|...|     |.|.|:| :.||  ...|:|::.|.|:.:
Mouse   571 AYKQLVRARFTRSFLAQIIGLRMHYKYFETD-----DPEFYKSKVCFI--LNNDMSEMELVFAEE 628

  Fly   861 Q----DVMGKIVTLALHPGGKARVVNDHNKLVYIHYMAFFHMNTQIREQTIAFNRGFRSIVNPEW 921
            :    ..:.|||.|.  .||....|.:.||:.|::.:|.:.:.:|::|:...|.:|...:|....
Mouse   629 KYNKSGQLDKIVELM--TGGAQTPVTNANKIFYLNLLAQYRLASQVKEEVEHFLKGLNELVPENL 691

  Fly   922 LSLFSPPELQRLISGDTSPLDLKDLQKHTHYYGG-FHDTHQVVCWLWDILAKDFTEEERKLFLKF 985
            |::|...||:.|:.| |..:::.|.:.|....|| :|...:|:.|.|.::: ..|:||....|:|
Mouse   692 LAIFDENELELLMCG-TGDINVSDFKAHAVVVGGSWHFREKVMRWFWAVVS-SLTQEELARLLQF 754

  Fly   986 VTSCSKPPLLGFAHLEPPFSIRCVEVSDDEDTGDTIGSVIRGFFAIRKKDPLNRLPTSSTCFNLL 1050
            .|..|:.|..|||.|.|.|.|......                         :.|||:.||||.|
Mouse   755 TTGSSQLPPGGFAALCPSFQIIAAPTH-------------------------STLPTAHTCFNQL 794

  Fly  1051 KLPNYQKKSTLRDKLRYAVSSN-TGF 1075
            .||.|.....:...|:.|:|.. .||
Mouse   795 CLPTYDSYEEVHRMLQLAISEGCEGF 820

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5087	NP_648279.1	HECTc	694..1076	CDD:238033	111/401 (28%)
CG5087	NP_648279.1	HECTc	718..1075	CDD:214523	107/375 (29%)
Arel1	NP_001351118.1	Filamin	56..154	CDD:395505
		Filamin	64..158
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	315..345		5/42 (12%)
		HECTc	464..821	CDD:238033	111/401 (28%)
		Interaction with SOCS2. /evidence=ECO:0000250\|UniProtKB:O15033	483..789		96/349 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900