DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment CG5087 and Herc4

DIOPT Version :9

Sequence 1:NP_648279.1 Gene:CG5087 / 39035 FlyBaseID:FBgn0035953 Length:1078 Species:Drosophila melanogaster
Sequence 2:NP_084390.1 Gene:Herc4 / 67345 MGIID:1914595 Length:1057 Species:Mus musculus


Alignment Length:389 Identity:109/389 - (28%)
Similarity:175/389 - (44%) Gaps:46/389 - (11%)


- Green bases have known domain annotations that are detailed below.


  Fly   693 LIVIHRDRIVEDGYRQLAAQPTQALKGVIRVRFINQQGLHEAGIDQDGVFKEFLEETIKKVFDPS 757
            ::|:.|:.||.|....|........|..::|.|:.     |..:|..||.|||....::::.||.
Mouse   710 ILVVRRENIVGDAMEVLRKTKNIDYKKPLKVIFVG-----EDAVDAGGVRKEFFLLIMRELLDPK 769

  Fly   758 LNLFKTTSDQRLYPSPISYVQDNHLELFEFVGRMLGKAVYEGIVVDVPFASFFLSQLLGQTQQAL 822
            ..:|:...|.||........:|:  :||..:|.:.|.|:|...:||:.|......:||.:...  
Mouse   770 YGMFRYYEDSRLIWFSDKTFEDS--DLFHLIGVICGLAIYNFTIVDLHFPLALYKKLLKRKPS-- 830

  Fly   823 YSCMDELPSLDNELYRSLTFIKHYKQDVSD----LNLTFSVDQDVMGKIVTLALHPGGKARVVND 883
               :|:|..|...:.||:..:..|.:|..:    ||.|.:|:.....::..|.|:  |....||.
Mouse   831 ---LDDLKELMPAVGRSMQQLLDYPEDDIEETFCLNFTITVENFGATEVKELVLN--GADTAVNR 890

  Fly   884 HNKLVYIHYMAFFHMNTQIREQTIAFNRGFRSIVNPEWLSLFSPPELQRLISGDTSPLDLKDLQK 948
            .|:..::.....:..|..:.....||:.||..:...:.|.||.|.|||.::.|:|: .|.|:|:|
Mouse   891 QNRQEFVDAYVDYIFNKSVASLFDAFHAGFHKVCGGKVLLLFQPNELQAMVIGNTN-YDWKELEK 954

  Fly   949 HTHYYGGFHDTHQVVCWLWDILAKDFTEEERKLFLKFVTSCSKPPLLGFAHLEPPFSIRCVEVSD 1013
            :|.|.|.:...|..:...|::. .:...|::|.||.|:|...:.|:||...|:        .|..
Mouse   955 NTEYKGEYWADHPTIKIFWEVF-HELPLEKKKQFLLFLTGSDRIPILGMKSLK--------LVIQ 1010

  Fly  1014 DEDTGDTIGSVIRGFFAIRKKDPLNRLPTSSTCFNLLKLPNYQKKSTLRDKLRYAVSSNTGFEL 1077
            ....|::.                  ||.|.||||||.||.|.:|.|||.||..|:..|.||.|
Mouse  1011 STGGGESY------------------LPVSHTCFNLLDLPKYTEKETLRCKLIQAIDHNEGFSL 1056

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG5087NP_648279.1 HECTc 694..1076 CDD:238033 107/385 (28%)
HECTc 718..1075 CDD:214523 100/360 (28%)
Herc4NP_084390.1 RCC1 1 1..51
RCC1 3..49 CDD:278826
RCC1 2 52..101
RCC1 52..99 CDD:278826
RCC1 3 102..154
RCC1 102..152 CDD:278826
RCC1 4 156..207
RCC1 157..205 CDD:278826
RCC1 5 208..259
RCC1 208..257 CDD:278826
RCC1 260..308 CDD:278826
RCC1 6 261..311
RCC1 7 313..366
RCC1 313..>343 CDD:278826
HECTc 709..1055 CDD:238033 107/386 (28%)
HECTc 735..1054 CDD:214523 100/360 (28%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5021
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.900

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