DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5087 and Wwp2

DIOPT Version :9

Sequence 1:	NP_648279.1	Gene:	CG5087 / 39035	FlyBaseID:	FBgn0035953	Length:	1078	Species:	Drosophila melanogaster
Sequence 2:	NP_080106.1	Gene:	Wwp2 / 66894	MGIID:	1914144	Length:	870	Species:	Mus musculus

Alignment Length:	391	Identity:	115/391 - (29%)
Similarity:	178/391 - (45%)	Gaps:	35/391 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly   687 ASPRSALIVIHRDRIVEDGYRQLAAQPTQALKGVIRVRFINQQGLHEAGIDQDGVFKEFLEETIK 751
            |.|....|.:.|..:.||.::|:.......|:   |..:|..:|  |.|:|..|:.:|:......
Mouse   510 ALPSHVKISVSRQTLFEDSFQQIMNMKPYDLR---RRLYIIMRG--EEGLDYGGIAREWFFLLSH 569

  Fly   752 KVFDPSLNLFKTTSDQR--LYPSPISYVQDNHLELFEFVGRMLGKAVYEGIVVDVPFASFFLSQL 814
            :|.:|...||:......  |..:|.|.:..:||..|.|:||.:..|:|.|..:|..|...|..::
Mouse   570 EVLNPMYCLFEYAGKNNYCLQINPASSINPDHLTYFRFIGRFIAMALYHGKFIDTGFTLPFYKRM 634

  Fly   815 LGQTQQALYSCMDELPSLDNELYRSLTFIKHYKQDVSDLNLTFSVDQDVMGKIVTLALHPGGKAR 879
            |.:.     ..:.:|.|:|.|.|.|:.:||....:...|.|.|..|.:::||:.|..|..||:..
Mouse   635 LNKR-----PTLKDLESIDPEFYNSIVWIKENNLEECGLELFFIQDMEILGKVTTHELKEGGENI 694

  Fly   880 VVNDHNKLVYIHYMAFFHMNTQIREQTIAFNRGFRSIVNPEWLSLFSPPELQRLISGDTSPLDLK 944
            .|.:.||..||..:..:.....:.|||.||..||..:...|||..|...||:.::.| ...:|:.
Mouse   695 RVTEENKEEYIMLLTDWRFTRGVEEQTKAFLDGFNEVAPLEWLRYFDEKELELMLCG-MQEIDMS 758

  Fly   945 DLQKHTHYYGGFHDTHQVVCWLWDILAKDFTEEERKLFLKFVTSCSKPPLLGFAHLEPPFSIRCV 1009
            |.||:. .|..:..:.:.:.|.|.:: |:...|:|...|:|||...:.|:.|||.|
Mouse   759 DWQKNA-IYRHYTKSSKQIQWFWQVV-KEMDNEKRIRLLQFVTGTCRLPVGGFAEL--------- 812

  Fly  1010 EVSDDEDTGDTIGSVIRGFFAIRKKDPLNRLPTSSTCFNLLKLPNYQKKSTLRDKLRYAVSSNTG 1074
                       |||.....|.|.:......||.|.||||.|.||.|:....|::||.||:....|
Mouse   813 -----------IGSNGPQKFCIDRVGKETWLPRSHTCFNRLDLPPYKSYEQLKEKLLYAIEETEG 866

  Fly  1075 F 1075
            |
Mouse   867 F 867

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5087	NP_648279.1	HECTc	694..1076	CDD:238033	113/384 (29%)
CG5087	NP_648279.1	HECTc	718..1075	CDD:214523	105/358 (29%)
Wwp2	NP_080106.1	C2_E3_ubiquitin_ligase	17..142	CDD:175988
		PRK07003	<149..>299	CDD:235906
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	150..300
		WW	302..331	CDD:366073
		WW	332..361	CDD:366073
		WW	407..435	CDD:366073
		WW	447..477	CDD:238122
		HECTc	516..868	CDD:238033	113/385 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810