DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5087 and Smurf2

DIOPT Version :9

Sequence 1:	NP_648279.1	Gene:	CG5087 / 39035	FlyBaseID:	FBgn0035953	Length:	1078	Species:	Drosophila melanogaster
Sequence 2:	NP_079757.2	Gene:	Smurf2 / 66313	MGIID:	1913563	Length:	748	Species:	Mus musculus

Alignment Length:	823	Identity:	187/823 - (22%)
Similarity:	318/823 - (38%)	Gaps:	192/823 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   327 IDGQGESKELAYPLLTETTTSLLELIPNTVTTKGVFTQWHEL-LGWHTPGPEPAQNQNVALIKKQ 390
            :||.|:...      |:|       :.||:..|  :.|.::| :|         ::.:|.:
Mouse    41 VDGSGQCHS------TDT-------VKNTLDPK--WNQHYDLYIG---------KSDSVTI---- 77

  Fly   391 FHMLWDHR------------CIKLLLGDLLKQINLNYERIEF--QSPQQPSISNLLRRALERSST 441
              .:|:|:            |::||...:.:..:..|:|::.  ..|.            :..:.
Mouse    78 --SVWNHKKIHKKQGAGFLGCVRLLSNAINRLKDTGYQRLDLCKLGPN------------DNDTV 128

  Fly   442 RGVNLMGVASSKQSKQQWRKLDSAEVVQVSRICG-----------------MYYAALNTLSQMKL 489
            ||    .:..|.||:.  |.....:||..||:..                 .|...:...:|.:.
Mouse   129 RG----QIVVSLQSRD--RIGTGGQVVDCSRLFDNDLPDGWEERRTASGRIQYLNHITRTTQWER 187

  Fly   490 DILTGICYSD-----NVLYDIWLLITSL-GPNCGMKEYLELLKSETNLQKPQTAMLMLFCDCMTH 548
            .......||.     :...|....||.. |..||......|.:.....|:.:..|      ..||
Mouse   188 PTRPASEYSSPGRPLSCFVDENTPITGTNGATCGHSSDPRLAERRVRSQRHRNYM------SRTH 246

  Fly   549 YVTILDEHEMYTEQNPFKLNDYVLLTYF-------------LNNILYKLIND--------NLLAG 592
            ..|..|..|.|.::...:...|.|.|..             |:||..:.:..        |...|
Mouse   247 LHTPPDLPEGYEQRTTQQGQVYFLHTQTGVSTWHDPRVPRDLSNINCEELGPLPPGWEIRNTATG 311

  Fly   593 AKNIVQH----------PVFLSLHTLMLCLYRRDCRRPFTPPKHWLIPEVKPSTFINDLEKAKRN 647
            ....|.|          .:..:||   |.|.|::..:  ...:..::|.....|....:.:.||:
Mouse   312 RVYFVDHNNRTTQFTDPRLSANLH---LVLNRQNQLK--DQQQQQVVPLCPDDTECLTVPRYKRD 371

  Fly   648 AMLLLAKMPHIIPHEDRVKLFRKFVQNEKAVMGLTESACASPRSALIVIHRDRIVEDGYRQLAAQ 712
            .:             .::|:.|:.:..::...|          ...|.:.|:.|.|:.|||:...
Mouse   372 LV-------------QKLKILRQELSQQQPQAG----------HCRIEVSREEIFEESYRQVMKM 413

  Fly   713 PTQALKGVIRVRFINQQGLHEAGIDQDGVFKEFLEETIKKVFDPSLNLFKTTSDQ--RLYPSPIS 775
            ..:.|...:.::|..::||     |..||.:|:|.....::.:|...||:.:.|.  .|..:|.|
Mouse   414 RPKDLWKRLMIKFRGEEGL-----DYGGVAREWLYLLSHEMLNPYYGLFQYSRDDIYTLQINPDS 473

  Fly   776 YVQDNHLELFEFVGRMLGKAVYEGIVVDVPFASFFLSQLLGQTQQALYSCMDELPSLDNELYRSL 840
            .|...||..|.||||::|.||:.|..:|..|...|..||||::     ..:|::..:|.:|:.||
Mouse   474 AVNPEHLSYFHFVGRIMGMAVFHGHYIDGGFTLPFYKQLLGKS-----ITLDDMELVDPDLHNSL 533

  Fly   841 TFIKHYKQDVSD-LNLTFSVDQDVMGKIVTLALHPGGKARVVNDHNKLVYIHYMAFFHMNTQIRE 904
            .:|  .:.|::. |:.||.|:.:..|:|:...|.|.||:..|.:.||..|:.....:.....|..
Mouse   534 VWI--LENDITGVLDHTFCVEHNAYGEIIQHELKPNGKSIPVTEENKKEYVRLYVNWRFLRGIEA 596

  Fly   905 QTIAFNRGFRSIVNPEWLSLFSPPELQRLISGDTSPLDLKDLQKHTHYYGGFHDTHQVVCWLWDI 969
            |.:|..:||..::....|..|...||:.:|.| ...:|:.|.:.:|.......|:: ||.|.|.
Mouse   597 QFLALQKGFNEVIPQHLLKTFDEKELELIICG-LGKIDVSDWKVNTRLKHCTPDSN-VVKWFWK- 658

  Fly   970 LAKDFTEEERKL-FLKFVTSCSKPPLLGFAHLEPPFSIRCVEVSDDEDTGDTIGSVIRGFFAIRK 1033
             |.:|.:|||:. .|:|||..|:.||.||..|:                    |:.....|.|.:
Mouse   659 -AVEFFDEERRARLLQFVTGSSRVPLQGFKALQ--------------------GAAGPRLFTIHQ 702

  Fly  1034 KDP-LNRLPTSSTCFNLLKLPNYQKKSTLRDKLRYAVSSNTGF 1075
            .|. .|.||.:.||||.:.:|.|:....|.:||..|:....||
Mouse   703 IDACTNNLPKAHTCFNRIDIPPYESYEKLYEKLLTAIEETCGF 745

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5087	NP_648279.1	HECTc	694..1076	CDD:238033	116/387 (30%)
CG5087	NP_648279.1	HECTc	718..1075	CDD:214523	106/361 (29%)
Smurf2	NP_079757.2	C2_Smurf-like	13..137	CDD:176028	23/141 (16%)
		WW	159..188	CDD:278809	2/28 (7%)
		WW	252..283	CDD:197736	6/30 (20%)
		WW	298..330	CDD:197736	4/31 (13%)
		HECTc	393..745	CDD:238033	114/387 (29%)
		HECTc	420..745	CDD:214523	106/360 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810