Protein Alignment CG5087 and SMURF2

DIOPT Version :10

• Sequence 1: NP_648279.1
• Gene: CG5087 / 39035
• FlyBaseID: FBgn0035953
• Length: 1078
• Species: Drosophila melanogaster
• Sequence 2: XP_047292502.1
• Gene: SMURF2 / 64750
• HGNCID: 16809
• Length: 750
• Species: Homo sapiens
• Alignment Length: 860
• Identity: 188/860 - (21%)
• Similarity: 314/860 - (36%)
• Gaps: 266/860 - (30%)

  Fly   327 IDGQGESKELAYPLLTETTTSLLELIPNTVTTKGVFTQWHEL-LGWHTPGPEPAQNQNVALIKKQ 390
            :||.|:...      |:|       :.||:..|  :.|.::| :|         ::.:|.:
Human    43 VDGSGQCHS------TDT-------VKNTLDPK--WNQHYDLYIG---------KSDSVTI---- 79

  Fly   391 FHMLWDHR------------CIKLLLGDLLKQINLNYERIEF--QSPQQPSISNLLRRALERSST 441
              .:|:|:            |::||...:.:..:..|:|::.  ..|.            :..:.
Human    80 --SVWNHKKIHKKQGAGFLGCVRLLSNAINRLKDTGYQRLDLCKLGPN------------DNDTV 130

  Fly   442 RGVNLMGVASSKQSKQQWRKLDSAEVVQVSRICGMYYAALNTLSQMKLDILTGICYSDNVLYDIW 506
            ||    .:..|.||:.  |.....:||..||:                        .||.|.|.|
Human   131 RG----QIVVSLQSRD--RIGTGGQVVDCSRL------------------------FDNDLPDGW 165

  Fly   507 LLITSLGPNCGMKEYLELLKSETNLQKPQTAM---------LMLFCD------------C----- 545
               .......|..:||..:...|..::|....         |..|.|            |
Human   166 ---EERRTASGRIQYLNHITRTTQWERPTRPASEYSSPGRPLSCFVDENTPISGTNGATCGQSSD 227

  Fly   546 ------------------MTHYVTILDEHEMYTEQNPFKLNDYVLLTYF-------------LNN 579
                              .||..|..|..|.|.::...:...|.|.|..             |:|
Human   228 PRLAERRVRSQRHRNYMSRTHLHTPPDLPEGYEQRTTQQGQVYFLHTQTGVSTWHDPRVPRDLSN 292

  Fly   580 ILYKLIND--------NLLAGAKNIVQH----------PVFLSLHTLM----------------L 610
            |..:.:..        |...|....|.|          .:..:||.::                |
Human   293 INCEELGPLPPGWEIRNTATGRVYFVDHNNRTTQFTDPRLSANLHLVLNRQNQLKDQQQQQVVSL 357

  Fly   611 CLYRRDCRRPFTPPKHWLIPEVKPSTFINDLEKAKRNAMLLLAKMPHIIPHEDRVKLFRKFVQNE 675
            |....:|   .|.|::                  ||:.:             .::|:.|:.:..:
Human   358 CPDDTEC---LTVPRY------------------KRDLV-------------QKLKILRQELSQQ 388

  Fly   676 KAVMGLTESACASPRSALIVIHRDRIVEDGYRQLAAQPTQALKGVIRVRFINQQGLHEAGIDQDG 740
            :...|          ...|.:.|:.|.|:.|||:.....:.|...:.::|..::||     |..|
Human   389 QPQAG----------HCRIEVSREEIFEESYRQVMKMRPKDLWKRLMIKFRGEEGL-----DYGG 438

  Fly   741 VFKEFLEETIKKVFDPSLNLFKTTSDQ--RLYPSPISYVQDNHLELFEFVGRMLGKAVYEGIVVD 803
            |.:|:|.....::.:|...||:.:.|.  .|..:|.|.|...||..|.||||::|.||:.|..:|
Human   439 VAREWLYLLSHEMLNPYYGLFQYSRDDIYTLQINPDSAVNPEHLSYFHFVGRIMGMAVFHGHYID 503

  Fly   804 VPFASFFLSQLLGQTQQALYSCMDELPSLDNELYRSLTFIKHYKQDVSD-LNLTFSVDQDVMGKI 867
            ..|...|..||||::     ..:|::..:|.:|:.||.:|  .:.|::. |:.||.|:.:..|:|
Human   504 GGFTLPFYKQLLGKS-----ITLDDMELVDPDLHNSLVWI--LENDITGVLDHTFCVEHNAYGEI 561

  Fly   868 VTLALHPGGKARVVNDHNKLVYIHYMAFFHMNTQIREQTIAFNRGFRSIVNPEWLSLFSPPELQR 932
            :...|.|.||:..||:.||..|:.....:.....|..|.:|..:||..::....|..|...||:.
Human   562 IQHELKPNGKSIPVNEENKKEYVRLYVNWRFLRGIEAQFLALQKGFNEVIPQHLLKTFDEKELEL 626

  Fly   933 LISGDTSPLDLKDLQKHTHYYGGFHDTHQVVCWLWDILAKDFTEEERKL-FLKFVTSCSKPPLLG 996
            :|.| ...:|:.|.:.:|.......|:: :|.|.|.  |.:|.:|||:. .|:|||..|:.||.|
Human   627 IICG-LGKIDVNDWKVNTRLKHCTPDSN-IVKWFWK--AVEFFDEERRARLLQFVTGSSRVPLQG 687

  Fly   997 FAHLEPPFSIRCVEVSDDEDTGDTIGSVIRGFFAIRKKDP-LNRLPTSSTCFNLLKLPNYQKKST 1060
            |..|:                    |:.....|.|.:.|. .|.||.:.||||.:.:|.|:....
Human   688 FKALQ--------------------GAAGPRLFTIHQIDACTNNLPKAHTCFNRIDIPPYESYEK 732

  Fly  1061 LRDKLRYAVSSNTGF 1075
            |.:||..|:....||
Human   733 LYEKLLTAIEETCGF 747

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG5087	NP_648279.1	IQCD	20..50	CDD:467745
		HECTc	694..1076	CDD:238033	116/387 (30%)
SMURF2	XP_047292502.1	C2_Smurf-like	19..139	CDD:176028	23/141 (16%)
		HUL4	<161..747	CDD:227354	154/668 (23%)