DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5087 and HACE1

DIOPT Version :9

Sequence 1:	NP_648279.1	Gene:	CG5087 / 39035	FlyBaseID:	FBgn0035953	Length:	1078	Species:	Drosophila melanogaster
Sequence 2:	NP_065822.2	Gene:	HACE1 / 57531	HGNCID:	21033	Length:	909	Species:	Homo sapiens

Alignment Length:	1140	Identity:	250/1140 - (21%)
Similarity:	404/1140 - (35%)	Gaps:	409/1140 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    96 RARERLERICRYIIKA----MESENTKLSYAALCLFKERSLPWIAHIKILLTNCLTLLPELKPEN 156
            ||.|:|.|:.|.:.:|    :..:|....|                         ||:|.:..:.
Human     3 RAMEQLNRLTRSLRRARTVELPEDNETAVY-------------------------TLMPMVMADQ 42

  Fly   157 HADSLSLALFLHTLVVFTAPKSWAILRNAQFEKLQPAMQKICCNIQGHLVQHDFYKIMRLVL-IR 220
            |. |:|                 .:|.|::|:                 |.:.|.::.|.:| |.
Human    43 HR-SVS-----------------ELLSNSKFD-----------------VNYAFGRVKRSLLHIA 72

  Fly   221 GTVREELSVKPVTLVAIITLCLRPLIDGNF------------SRNLLAKFLSEILSVPA------ 267
            .....         |..:.|.|:...:.|:            :||...|.:|::|...|
Human    73 ANCGS---------VECLVLLLKKGANPNYQDISGCTPLHLAARNGQKKCMSKLLEYSADVNICN 128

  Fly   268 -----------------LIYHLQQSVPQCLEQFSSMGLLKKALSISGDVQWFEEFGTSMPGTKS- 314
                             |::.|.|.|.. ::...:||  :.||.::           ...|.|:
Human   129 NEGLTAIHWLAVNGRTELLHDLVQHVSD-VDVEDAMG--QTALHVA-----------CQNGHKTT 179

  Fly   315 ---LAFLGNIVNLFNIDGQGESKELAYPLL-------TETTTSLL----ELIP--NTVT------ 357
               |...|..:|..|:.|       |.||.       .:|...||    :.:|  |.||
Human   180 VQCLLDSGADINRPNVSG-------ATPLYFACSHGQRDTAQILLLRGAKYLPDKNGVTPLDLCV 237

  Fly   358 ------TKGVFTQWHELLGWHTPGPEPAQ-----NQNVALIKKQFHMLWDH-------RCIKLLL 404
                  |..|..|:|         |...|     .||..|.:.....:.:|       :.:|:|.
Human   238 QGGYGETCEVLIQYH---------PRLFQTIIQMTQNEDLRENMLRQVLEHLSQQSESQYLKILT 293

  Fly   405 ---------GDLLKQINLNYERIEFQSPQQPSISNLLR------RALERSSTRGVNLMGVASSKQ 454
                     |..|..::.||:      .|..|:..::|      |....|.:.|:: ||...:|.
Human   294 SLAEVATTNGHKLLSLSSNYD------AQMKSLLRIVRMFCHVFRIGPSSPSNGID-MGYNGNKT 351

  Fly   455 SKQQ--------WRKLDSAEVVQVSRICGMYYAALNTLSQMKLDILTGICYSDNVLYDIWLLITS 511
            .:.|        |..||...|:..:.           |.:.|.|...               |||
Human   352 PRSQVFKPLELLWHSLDEWLVLIATE-----------LMKNKRDSTE---------------ITS 390

  Fly   512 L--------------------GPNCGMKEYLELLKSETNLQKPQ--------------------- 535
            :                    ||..     .|.|.:.|...||.
Human   391 ILLKQKGQDQDAASIPPFEPPGPGS-----YENLSTGTRESKPDALAGRQEASADCQDVISMTAN 450

  Fly   536 --TAMLMLF---CDC-----MT--HYVTILDEHEMYTEQNPFKLNDYVLLTYFLNNILYKLINDN 588
              :|::..|   |.|     ||  .::..:.:|:                     .:|...:|.|
Human   451 RLSAVIQAFYMCCSCQMPPGMTSPRFIEFVCKHD---------------------EVLKCFVNRN 494

  Fly   589 LLAGAKNIVQHPVFLSLHTLMLCLYRRDCRRPFTPPKHWLIPEVKPSTFINDLEKAKRNAMLLLA 653
                .|.|..|     .|.|:.|                  ||                   |::
Human   495 ----PKIIFDH-----FHFLLEC------------------PE-------------------LMS 513

  Fly   654 KMPHII---PHEDRVKLFRKFVQNEKAVMGLTESACAS---PRSALIVIHRDRIVEDGYRQLAAQ 712
            :..|||   |.:||.:.|.:.:.:     |..:|....   ..:.::::|||.|.......::..
Human   514 RFMHIIKAQPFKDRCEWFYEHLHS-----GQPDSDMVHRPVNENDILLVHRDSIFRSSCEVVSKA 573

  Fly   713 PTQALKGVIRVRFINQQGLHEAGIDQDGVFKEFLEETIKKVFDPSLNLFKTTSDQRLY-PSPISY 776
            ....||..|.|||..::|:.:      ||.:|:.:....::.:|...||..::|...: |:..||
Human   574 NCAKLKQGIAVRFHGEEGMGQ------GVVREWFDILSNEIVNPDYALFTQSADGTTFQPNSNSY 632

  Fly   777 VQDNHLELFEFVGRMLGKAVYEGIVVDVPFASFFLSQLLGQTQQALYSCMDELPSLDNELYRSLT 841
            |..:||..|.|.|::||.|:....:|::.|...|...:||     :.....::.|:|.|..::|.
Human   633 VNPDHLNYFRFAGQILGLALNHRQLVNIYFTRSFYKHILG-----IPVNYQDVASIDPEYAKNLQ 692

  Fly   842 FIKHYKQDVSD--LNLTFSVDQDVMGKIVTLALHPGGKARVVNDHNKLVYIHYMAFFHMNTQIRE 904
            :|  ...|:||  |.|||||:.||.|.:..:.|.|||.:.:|..:||..|:..:....|...|:.
Human   693 WI--LDNDISDLGLELTFSVETDVFGAMEEVPLKPGGGSILVTQNNKAEYVQLVTELRMTRAIQP 755

  Fly   905 QTIAFNRGFRSIVNPEWLSLFSPPELQRLISGDTSPLDLKDLQKHTHYYGGFHDTHQVVCWLWDI 969
            |..||.:||...:.|..:.||...||:.|:|| ...:|:.|..|:|.|..|:.....|:.|.|::
Human   756 QINAFLQGFHMFIPPSLIQLFDEYELELLLSG-MPEIDVSDWIKNTEYTSGYEREDPVIQWFWEV 819

  Fly   970 LAKDFTEEERKLFLKFVTSCSKPPLLGFAHLEPPFSIRCVEVSDDEDTGDTIGSVIRGFFAIRKK 1034
            : :|.|:|||.|.|:|||..|:.|..|||::..                   ||.::.|......
Human   820 V-EDITQEERVLLLQFVTGSSRVPHGGFANIMG-------------------GSGLQNFTIAAVP 864

  Fly  1035 DPLNRLPTSSTCFNLLKLPNYQKKSTLRDKLRYAV 1069
            ...|.|||||||.|:||||.|..|..|:|:|..|:
Human   865 YTPNLLPTSSTCINMLKLPEYPSKEILKDRLLVAL 899

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5087	NP_648279.1	HECTc	694..1076	CDD:238033	121/379 (32%)
CG5087	NP_648279.1	HECTc	718..1075	CDD:214523	116/355 (33%)
HACE1	NP_065822.2	Ank_2	<27..>283	CDD:330894	61/354 (17%)
		ANK 1	64..93		6/37 (16%)
		ANK repeat	66..95	CDD:293786	7/37 (19%)
		ANK	92..217	CDD:238125	26/145 (18%)
		ANK repeat	97..128	CDD:293786	6/30 (20%)
		ANK 2	97..126		6/28 (21%)
		ANK repeat	130..161	CDD:293786	4/31 (13%)
		ANK 3	130..159		4/29 (14%)
		ANK repeat	163..194	CDD:293786	9/43 (21%)
		ANK 4	163..192		8/41 (20%)
		ANK 5	196..226		7/36 (19%)
		ANK repeat	196..221	CDD:293786	7/31 (23%)
		ANK 6	228..257		8/37 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	398..433		7/39 (18%)
		HECTc	554..903	CDD:238033	121/380 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810