DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5087 and HECW2

DIOPT Version :9

Sequence 1:	NP_648279.1	Gene:	CG5087 / 39035	FlyBaseID:	FBgn0035953	Length:	1078	Species:	Drosophila melanogaster
Sequence 2:	XP_006712709.1	Gene:	HECW2 / 57520	HGNCID:	29853	Length:	1579	Species:	Homo sapiens

Alignment Length:	940	Identity:	219/940 - (23%)
Similarity:	360/940 - (38%)	Gaps:	243/940 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   174 TAPKSWAILRNA----QFEKLQPAMQKI---CCN---------IQGHLVQHDFYKIMRLVLIRGT 222
            |||.:..:|:.:    |.|:|....|.|   ..|         |.|...:.||::      ....
Human   846 TAPPAPQVLQRSNSIQQMEQLNRRYQSIRRTMTNERPEENTNAIDGAGEEADFHQ------ASAD 904

  Fly   223 VREELSVKPVTLVAIITLCLR-PLIDGNFSRNLLAKFLSEILSVPALIYHLQQSVPQCLEQFSSM 286
            .|.|..:...|..:.|||.|: |.:          |||     :....:.:..|.|.....|::.
Human   905 FRRENILPHSTSRSRITLLLQSPPV----------KFL-----ISPEFFTVLHSNPSAYRMFTNN 954

  Fly   287 GLLKKALS-ISGDVQWFEEFGTSMPGTKSLAFLGNIVNLFNIDGQGESKELAYPLLTETTTSLLE 350
            ..||..:: :..|...||.:..:..       |...:|:|      .:|:|..|
Human   955 TCLKHMITKVRRDTHHFERYQHNRD-------LVGFLNMF------ANKQLELP----------- 995

  Fly   351 LIPNTVTTKGVFTQWHELLGWHTPGPEPAQNQNVALIKKQFHMLWDHRCIKLLLGDLLKQINLNY 415
                              .||                    .|..||:.....       ::.|.
Human   996 ------------------RGW--------------------EMKHDHQGKAFF-------VDHNS 1015

  Fly   416 ERIEFQSPQQPSISNLLRRALERSSTRGVNLMGVASSKQSKQQWRKLDSAEVVQVSRICG----- 475
            ....|..|:.|..|:....||..              :|...:.|...:.||.:.||..|
Human  1016 RTTTFIDPRLPLQSSRPTSALVH--------------RQHLTRQRSHSAGEVGEDSRHAGPPVLP 1066

  Fly   476 MYYAALNTLSQMKLDILTGICYSDNVLY-----DIWLLITSLGP----NCGMKEYLELLKSETNL 531
            ...:..||:|:.:...:..:.|:|.::.     :|:.::....|    |..::|.::.:::|..
Human  1067 RPSSTFNTVSRPQYQDMVPVAYNDKIVAFLRQPNIFEILQERQPDLTRNHSLREKIQFIRTEGT- 1130

  Fly   532 QKPQTAMLMLFCDCMTHYVTILDEHEMYTEQNPFKLNDYVLLTYFLNNILYKLINDNLLAGAKNI 596
              |....|....|.:                        :||:.|...|:..:....||
Human  1131 --PGLVRLSSDADLV------------------------MLLSLFEEEIMSYVPPHALL------ 1163

  Fly   597 VQHPVFLSLHTLMLCLYRRDCRRPFTPPKHWLIPEVKPSTFINDLEKAKRNAMLLLAKMPHIIPH 661
              ||.:              |:.|...|..  .|:..|.|       .:.||.   |..|:....
Human  1164 --HPSY--------------CQSPRGSPVS--SPQNSPGT-------QRANAR---APAPYKRDF 1200

  Fly   662 EDRVKLFRKFVQNEKAVMGLTESACASPRSALIVIHRDRIVEDGYRQLAAQPTQAL-KGVIRVRF 725
            |.:::.|.:.::        |:.....|....::|.||.::||.:.|:.....:.| :..:.|.|
Human  1201 EAKLRNFYRKLE--------TKGYGQGPGKLKLIIRRDHLLEDAFNQIMGYSRKDLQRNKLYVTF 1257

  Fly   726 INQQGLHEAGIDQDGVFKEFLEETIKKVFDPSLNLFKTTSDQ--RLYPSPISYVQDNHLELFEFV 788
            :.::||     |..|..:||.....:::|:|...||:.:::.  .:..||:|...|||.|.|.|.
Human  1258 VGEEGL-----DYSGPSREFFFLVSRELFNPYYGLFEYSANDTYTVQISPMSAFVDNHHEWFRFS 1317

  Fly   789 GRMLGKAVYEGIVVDVPFASFFLSQLLGQTQQALYSCMDELPSLDNELYRSLTFIKHYKQDVSD- 852
            ||:||.|:....::|..|...|...||     .:...:.:|..||.|.::||.::|  ..|:.|
Human  1318 GRILGLALIHQYLLDAFFTRPFYKALL-----RILCDLSDLEYLDEEFHQSLQWMK--DNDIHDI 1375

  Fly   853 LNLTFSVDQDVMGKIVTLALHPGGKARVVNDHNKLVYIHYMAFFHMNTQIREQTIAFNRGFRSIV 917
            |:|||:|:::|.|:|....|.|||....|.:.||..||..|..:.:...:.:||.:..|||..:|
Human  1376 LDLTFTVNEEVFGQITERELKPGGANIPVTEKNKKEYIERMVKWRIERGVVQQTESLVRGFYEVV 1440

  Fly   918 NPEWLSLFSPPELQRLISGDTSPLDLKDLQKHTHYYGGFHDTHQVVCWLWDILAKDFTEEERKLF 982
            :...:|:|...||:.:|:| |:.:||.|.:.:|.|.||:||.|.|:.|.|..:.: |..|:|...
Human  1441 DARLVSVFDARELELVIAG-TAEIDLSDWRNNTEYRGGYHDNHIVIRWFWAAVER-FNNEQRLRL 1503

  Fly   983 LKFVTSCSKPPLLGFAHLEPPFSIRCVEVSDDEDTGDTIGSVIRGFFAIRKKDPLNRLPTSSTCF 1047
            |:|||..|..|..|||.|.                    ||.....|.:.|...:..||.:.|||
Human  1504 LQFVTGTSSIPYEGFASLR--------------------GSNGPRRFCVEKWGKITALPRAHTCF 1548

  Fly  1048 NLLKLPNYQKKSTLRDKLRYAVSSNTGFEL 1077
            |.|.||.|...|.|.:||..||...:.|.|
Human  1549 NRLDLPPYPSFSMLYEKLLTAVEETSTFGL 1578

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5087	NP_648279.1	HECTc	694..1076	CDD:238033	124/385 (32%)
CG5087	NP_648279.1	HECTc	718..1075	CDD:214523	117/359 (33%)
HECW2	XP_006712709.1	HECW_N	45..164	CDD:318711
		C2_NEDL1-like	185..321	CDD:176073
		NESP55	<471..638	CDD:115071
		PHA03169	591..>801	CDD:223003
		WW	816..845	CDD:306827
		WW	994..1023	CDD:306827	8/84 (10%)
		HECTc	1223..1577	CDD:238033	124/387 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810