Protein Alignment CG5087 and hace1

DIOPT Version :10

• Sequence 1: NP_648279.1
• Gene: CG5087 / 39035
• FlyBaseID: FBgn0035953
• Length: 1078
• Species: Drosophila melanogaster
• Sequence 2: NP_001410905.1
• Gene: hace1 / 572430
• ZFINID: ZDB-GENE-110411-52
• Length: 905
• Species: Danio rerio
• Alignment Length: 1058
• Identity: 247/1058 - (23%)
• Similarity: 422/1058 - (39%)
• Gaps: 264/1058 - (24%)

  Fly   110 KAMESENTKLSYAALCLFKERS--LPWIAHIKILLTNCLTLLPELKPENHADSLSLALFLHTLVV 172
            :|||..|.:|:.....|.:.|:  ||..:.     |...||:|.:..:.|.....|.|
Zfish     4 RAMEHLNVQLNRLTRSLRRARTVELPEDSE-----TAVYTLMPMVMADQHRSVSELLL------- 56

  Fly   173 FTAPKSWAILRNAQFE------KLQPAMQKICCNIQGHLVQHDFYKIMRLVLIRGTVREELSVKP 231
                       |::|:      :::.::..|..|...       .:.:.|:|.||.......:..
Zfish    57 -----------NSKFDVNYAFGRVKRSLLHIAANCGS-------VECLVLLLKRGANPNYQDISG 103

  Fly   232 VTLVAIIT-----LCLRPLIDGNFSRN------LLAKFLSEILSVPALIYHLQQSVPQCLEQFSS 285
            .|.:.:..     .|:..|::.|...|      |.|.....:.....|::.|.|.|.. ::...:
Zfish   104 CTPLHLAARNGQKKCMGRLLEYNADVNICNNEGLTAIHWLAVNGRTELLHDLVQHVTN-VDVEDA 167

  Fly   286 MGLLKKALSISGDVQWFEEFGTSMPGTKS----LAFLGNIVNLFNIDGQGESKELAYPLL----- 341
            ||  :.||.::           ...|.|:    |...|..:|..|:.|       |.||.
Zfish   168 MG--QTALHVA-----------CQNGHKTTVQCLLDSGADINRPNVSG-------ATPLYFACSH 212

  Fly   342 --TETTTSLL----ELIP--NTVT-----TKGVFTQWHELLGWHTPGP------EPAQNQNVALI 387
              .:|...||    :.:|  |.||     .:|.:.:..|:|..| .|.      :..||.::
Zfish   213 GQRDTAQILLLRGAKYLPDRNGVTPLDLCVQGGYGETCEILIQH-HGRLFQTLIQMTQNDDI--- 273

  Fly   388 KKQFHMLWDHRCIKLLLGDLLKQINLNYERIEFQSPQQPSISNLLRRALERSSTRGVNLMGVASS 452
                    ....::.:|..:.:|.:.||:||             |....|.::|.|..|:.::|:
Zfish   274 --------KENMLRQVLEHVSQQNDSNYQRI-------------LTSLAEVATTNGHKLLSLSSN 317

  Fly   453 KQSKQQWRKLDSAEVVQVSRI-CGMYY---AALNTLSQMKLDILTGICYSDN------VLYDIWL 507
            .:       :.:..::::.|| |.::.   ::.|..:.|.        |:.|      |...:.|
Zfish   318 FE-------VQTKSLLRIIRIFCHVFCLGPSSPNNGNDMG--------YNGNKTPRSQVFKPLEL 367

  Fly   508 LITSLGPNCGMKEYLELLKSETNLQKPQTAMLMLFCDCMTHYVTILDEHEMYTEQNPFKLND--Y 570
            |..||      .|:|.|:.:|...:...|.......|..:.::...:.....:.:||..|.|  .
Zfish   368 LWHSL------DEWLVLISTELEKEITDTTRSSSGNDIASLFLKKQEVDHSVSSENPQLLLDASS 426

  Fly   571 VLLT---YFLNNILYKLINDNLLAGAKNIVQ-----------HPV-------FLSLHTLML-CLY 613
            |:.|   |.....:..:|.:.|.|    ::|           |.:       |:..|..:| |..
Zfish   427 VMKTPEVYADGQDVISMIANRLSA----VIQAFYMCCSCQMPHGMTSPRFIEFVCKHDEVLKCFV 487

  Fly   614 RRDCRRPFTPPK------HWLI--PEVKPSTFINDLEKAKRNAMLLLAKMPHII---PHEDRVKL 667
            .|:       ||      |:|:  ||                   |:::..|||   |.:||.:.
Zfish   488 TRN-------PKIIFNHFHFLLECPE-------------------LMSRFMHIIKGQPFKDRCEW 526

  Fly   668 FRKFVQNEKAVMGLTESACAS---PRSALIVIHRDRIVEDGYRQLAAQPTQALKGVIRVRFINQQ 729
            |     .|..:.|..:|....   ..:.::::|||.:.......::....:.||..|.|||..::
Zfish   527 F-----YEHLLAGQPDSDMVHRPVNENDILLVHRDSLFRSSCEVVSKSSNEKLKQGIAVRFHGEE 586

  Fly   730 GLHEAGIDQDGVFKEFLEETIKKVFDPSLNLFKTTSDQRLY-PSPISYVQDNHLELFEFVGRMLG 793
            |:.:      ||.:|:.:....::.:|...||..::|...: |:..|.|..:||..|.|.|::||
Zfish   587 GMGQ------GVVREWFDILSNEIINPDYALFTQSADGTTFQPNSNSSVNPDHLNYFRFAGQILG 645

  Fly   794 KAVYEGIVVDVPFASFFLSQLLGQTQQALYSCMDELPSLDNELYRSLTFIKHYKQDVSD--LNLT 856
            .|:|...:|::.|...|...:||     :.....::.|:|.|..::|.:|  ...|:||  |.||
Zfish   646 LALYHRQLVNIYFTRSFYKHILG-----IPVSYQDVSSIDPEYAKNLQWI--LDNDISDLGLELT 703

  Fly   857 FSVDQDVMGKIVTLALHPGGKARVVNDHNKLVYIHYMAFFHMNTQIREQTIAFNRGFRSIVNPEW 921
            |||:.||.|.:..:.|.|||....|...||..|:..:....|...|:.|..||.:||.:.:.|..
Zfish   704 FSVETDVFGTMEEVPLKPGGTTIQVTQDNKEEYVQLVTELRMTRAIQPQINAFLQGFHTFIPPSL 768

  Fly   922 LSLFSPPELQRLISGDTSPLDLKDLQKHTHYYGGFHDTHQVVCWLWDILAKDFTEEERKLFLKFV 986
            :.||...||:.|:|| ...:|:.|.:::|.|..|:.....|:.|.|::: ::.|:|||.|.|:||
Zfish   769 IQLFDEYELELLLSG-MPEIDVMDWKRNTEYTSGYDLQEPVIQWFWEVV-ENLTQEERVLLLQFV 831

  Fly   987 TSCSKPPLLGFAHLEPPFSIRCVEVSDDEDTGDTIGSVIRGFFAIRKKDPLNRLPTSSTCFNLLK 1051
            |..|:.|..|||.|..                   ||.::.|.........|.|||||||.|:||
Zfish   832 TGSSRVPHGGFAFLMG-------------------GSGLQKFTVAAVPYTSNLLPTSSTCINMLK 877

  Fly  1052 LPNYQKKSTLRDKLRYAV 1069
            ||.|..|..|||:|..|:
Zfish   878 LPEYPSKDVLRDRLLVAL 895

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG5087	NP_648279.1	IQCD	20..50	CDD:467745
		HECTc	694..1076	CDD:238033	120/379 (32%)
hace1	NP_001410905.1	ANKYR	37..254	CDD:440430	48/262 (18%)
		ANK repeat	71..100	CDD:293786	6/35 (17%)
		ANK repeat	102..133	CDD:293786	5/30 (17%)
		ANK repeat	135..166	CDD:293786	6/31 (19%)
		ANK repeat	168..199	CDD:293786	9/43 (21%)
		ANK repeat	201..226	CDD:293786	7/31 (23%)
		ANK repeat	233..261	CDD:293786	8/28 (29%)
		HECTc	550..899	CDD:238033	120/380 (32%)