DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5087 and wwp2

DIOPT Version :9

Sequence 1:	NP_648279.1	Gene:	CG5087 / 39035	FlyBaseID:	FBgn0035953	Length:	1078	Species:	Drosophila melanogaster
Sequence 2:	XP_005163228.1	Gene:	wwp2 / 564527	ZFINID:	ZDB-GENE-000607-82	Length:	867	Species:	Danio rerio

Alignment Length:	394	Identity:	118/394 - (29%)
Similarity:	178/394 - (45%)	Gaps:	41/394 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly   687 ASPRSALIVIHRDRIVEDGYRQLAAQPTQALKGVIRVRFINQQGLHEAGIDQDGVFKEFLEETIK 751
            |.|....|.:.|..:.||.::|:.......|:   |..:|..:|  |.|:|..|:.:|:......
Zfish   507 ALPSHVKISVSRQTLFEDSFQQIMNMKPYDLR---RRLYIIMRG--EEGLDYGGIAREWFFLLSH 566

  Fly   752 KVFDPSLNLFKTTSDQR--LYPSPISYVQDNHLELFEFVGRMLGKAVYEGIVVDVPFASFFLSQL 814
            :|.:|...||:......  |..:|.|.:..:||..|.|:||.:..|:|.|..:|..|...|..::
Zfish   567 EVLNPMYCLFEYAGKNNYCLQINPASSINPDHLTYFRFIGRFIAMALYHGKFIDTGFTLPFYKRM 631

  Fly   815 LGQTQQALYSCMDELPSLDNELYRSLTFIKHYKQDVSDLNLTFSVDQDVMGKIVTLALHPGGKAR 879
            |.:.     ..:.:|.|:|.|.|.|:.::|....:...:.|.|:.|.:::||:.|..|...|:..
Zfish   632 LNKK-----PTLKDLESIDPEFYNSIMWVKENDLEECGVELYFAQDMEILGKVTTHQLKDDGENE 691

  Fly   880 VVNDHNKLVYIHYMAFFHMNTQIREQTIAFNRGFRSIVNPEWLSLFSPPELQRLISGDTSPLDLK 944
            :|...||..||..:..:.....:.|||.||..||..:|..|||..|...||:.::.| ...:||.
Zfish   692 LVTQDNKEEYIGLLTDWRFTRGVEEQTKAFLDGFNEVVPLEWLRYFDEKELELMLCG-MQEIDLN 755

  Fly   945 DLQKHT---HYYGGFHDTHQVVCWLWDILAKDFTEEERKLFLKFVTSCSKPPLLGFAHLEPPFSI 1006
            |.||:|   ||.......|    |.|.:: |:...|:|...|:|||...:.|:.|||.|
Zfish   756 DWQKNTIYRHYTKNSKQIH----WFWQVV-KEMDNEKRIRLLQFVTGTCRLPVGGFAEL------ 809

  Fly  1007 RCVEVSDDEDTGDTIGSVIRGFFAIRKKDPLNRLPTSSTCFNLLKLPNYQKKSTLRDKLRYAVSS 1071
                          |||.....|.|.|......||.|.||||.|.||.|:....||:||.:|:..
Zfish   810 --------------IGSNGPQKFCIDKVGKETWLPRSHTCFNRLDLPPYKNLEQLREKLLFAIEE 860

  Fly  1072 NTGF 1075
            ..||
Zfish   861 TEGF 864

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5087	NP_648279.1	HECTc	694..1076	CDD:238033	116/387 (30%)
CG5087	NP_648279.1	HECTc	718..1075	CDD:214523	108/361 (30%)
wwp2	XP_005163228.1	C2_E3_ubiquitin_ligase	17..145	CDD:175988
		WW	298..327	CDD:197736
		WW	328..357	CDD:278809
		WW	403..431	CDD:278809
		WW	441..473	CDD:197736
		HECTc	513..865	CDD:238033	116/388 (30%)
		HECTc	536..864	CDD:214523	109/363 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810