DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5087 and herc4

DIOPT Version :9

Sequence 1:	NP_648279.1	Gene:	CG5087 / 39035	FlyBaseID:	FBgn0035953	Length:	1078	Species:	Drosophila melanogaster
Sequence 2:	XP_005173092.1	Gene:	herc4 / 557513	ZFINID:	ZDB-GENE-070801-1	Length:	1052	Species:	Danio rerio

Alignment Length:	707	Identity:	163/707 - (23%)
Similarity:	285/707 - (40%)	Gaps:	154/707 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   411 INLNYERIEFQ---SPQQPSISNLLRRALERSSTRGVNLMGVASSKQSKQQWRKLDSAEVVQVSR 472
            :::|..|:.|.   ....|.||.::..:||:      ||:...||           |...::..|
Zfish   459 VDINTARLLFHKLIQTDHPQISQIIAASLEK------NLLPKLSS-----------SPPDIEALR 506

  Fly   473 ICGMYYAALNTLSQMKLDILTGICYSDNVLYDIWLLITSLGPNCGMKEYLELLKSETNLQKPQTA 537
            :    |.   ||.:..|     :|..:|        .|:|        .:...|:..:|   :.|
Zfish   507 L----YL---TLPECPL-----LCNPNN--------FTTL--------TIPFAKAIVSL---KDA 540

  Fly   538 MLMLFCDCMTHYVTILDEH--EMYTE---------QNPFKLNDYVLLTYFLNNILYKL-----IN 586
            .:.:..:..:.:..::.:.  |:|.|         :....|::..:.|.||:..|..|     :|
Zfish   541 PIKVLGNWWSRFEPVVFQRLVELYKEVVVYLLRMQKLGIPLSEQRIFTCFLDTSLKLLEILHSVN 605

  Fly   587 DNLLAGAKNIVQHPVFLSLHTLMLCLYRRDCRRPFTPPKHWLIPEVKPSTFINDLEKAKRNAMLL 651
            :.    |..|:|:..|. :|.|...:   |.|..:..   |         |...:.....::.:.
Zfish   606 ER----AGQIIQYDKFY-IHELDELI---DIRNDYAT---W---------FQQQMFSVVMDSQVT 650

  Fly   652 LAKMPHIIPHEDRVKLFR--KFVQNEKAV----------MGLTESACASPRSALI-VIHRDRIVE 703
            |.|.|.:...:.:..|.:  ..:|.:.||          :.|:.....|....|| ::.|:.:|.
Zfish   651 LCKYPFVFDAQAKTALLQTDAVIQMQMAVDQAQRQNFTSLFLSGGGVESVNPCLILIVRRENVVG 715

  Fly   704 DGYRQLAAQPTQALKGVIRVRFINQQGLHEAGIDQDGVFKEFLEETIKKVFDPSLNLFKTTSDQR 768
            |....|........|..::|.|:.     |..:|..||.|||....:|::..|...:|:...:.|
Zfish   716 DSMEVLRKSKNVDYKKPLKVIFVG-----EEAVDAGGVRKEFFLLIMKELLHPKYGMFRFHEESR 775

  Fly   769 LYPSPISYVQDNHLELFEFVGRMLGKAVYEGIVVDVPFASFFLSQLLGQTQQALYSCMDELPSLD 833
            |........:|  ::||..:|.:.|.|:|...:|::.|......:||.:|     ..:::|..|.
Zfish   776 LIWFACKTFED--IDLFHLIGVVCGLAIYNLTIVELNFPLALYKKLLKKT-----PTLEDLKELM 833

  Fly   834 NELYRSLTFIKHYKQDVSDLN----LTFSVDQDVMGKIVTLALHPGGKARVVNDHNKLVYIHYMA 894
            .::.|||..:..|.:|  ||.    |.|::.:|..|....:.|.|.|....||..|:..:::...
Zfish   834 PDVGRSLQQLLDYTED--DLEETFCLNFTITEDNFGATEVVELIPNGTDISVNKSNRQEFVNAYV 896

  Fly   895 FFHMNTQIREQTIAFNRGFRSIVNPEWLSLFSPPELQRLISGDTSPLDLKDLQKHTHYYGGFHDT 959
            .:..|..:..|..||..||..:...:.|.||.|.|||.::.|:|: .|.|:|:|.|.|.|.:...
Zfish   897 DYIFNKSVAPQFSAFYAGFHKVCGGKVLELFQPSELQAMVIGNTN-YDWKELEKSTEYKGEYWAD 960

  Fly   960 HQVVCWLWDILAKDFTEEERKLFLKFVTSCSKPPLLGFAHL----EPPFSIRCVEVSDDEDTGDT 1020
            |..:...|::. .:...|::|.||.|:|...:.|:||...|    :|                 |
Zfish   961 HPTIKIFWEVF-HELPLEKKKQFLLFLTGSDRIPILGMKSLALVIQP-----------------T 1007

  Fly  1021 IGSVIRGFFAIRKKDPLNRLPTSSTCFNLLKLPNYQKKSTLRDKLRYAVSSNTGFEL 1077
            .|.  ..:|           |.:.||||||.||.|..|:|:::||.:|:..|.||.|
Zfish  1008 AGG--EQYF-----------PVAHTCFNLLDLPKYTSKNTMQEKLLHAIEHNQGFNL 1051

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5087	NP_648279.1	HECTc	694..1076	CDD:238033	106/390 (27%)
CG5087	NP_648279.1	HECTc	718..1075	CDD:214523	100/364 (27%)
herc4	XP_005173092.1	RCC1	3..49	CDD:278826
		RCC1	52..99	CDD:278826
		RCC1	102..152	CDD:278826
		RCC1	156..205	CDD:278826
		RCC1	208..257	CDD:278826
		RCC1	260..308	CDD:278826
		RCC1	313..377	CDD:278826
		HECTc	704..1049	CDD:238033	106/390 (27%)
		HECTc	730..1049	CDD:214523	100/364 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810