DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5087 and PLEKHA5

DIOPT Version :9

Sequence 1:	NP_648279.1	Gene:	CG5087 / 39035	FlyBaseID:	FBgn0035953	Length:	1078	Species:	Drosophila melanogaster
Sequence 2:	NP_001243399.1	Gene:	PLEKHA5 / 54477	HGNCID:	30036	Length:	1282	Species:	Homo sapiens

Alignment Length:	700	Identity:	125/700 - (17%)
Similarity:	225/700 - (32%)	Gaps:	261/700 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 KAAREERALEKRREQA-AILLQSTLKGYAARRK----YQKRIILDFDAMFTENHDDKDAELELVA 74
            |..|::..|...||.. |.|:|..|:.::.:.:    :.:|..:..|....||        |.:.
Human   631 KLRRQQAELSSIREHTLAQLMQLKLEAHSPKNEILSHHLQRNTIYLDHQMKEN--------EPII 687

  Fly    75 SNVYPVL------------------------------RRYLTQIRLDKSDVRARERLERICRYII 109
            :.|:.::                              |..|.:.|.::.|:.|  :|.|:|
Human   688 TMVHTMIENSALRPQLYQQFLRQKSKISLYCLSQDEGRGTLYKYRPEEVDIDA--KLSRLC---- 746

  Fly   110 KAMESENTKLSYAALCLFKERSLPWIAHIKILLTNCLTLLPELKPENHADSLSLALFLHTLVV-- 172
                 |..|:.:|.     |..|..:...|..|...| |....:.|.|||:.:.   :.|:|:
Human   747 -----EQDKVVHAL-----EEKLQQLHKEKYTLEQAL-LSASQEIEMHADNPAA---IQTVVLQR 797

  Fly   173 ----------------FTA--PKSW----------AILRNAQFEKLQ--PAMQKICCNIQGHLVQ 207
                            .||  .::|          .:.||...|:|.  ..:|.....||...:|
Human   798 DDLQNGLLSTCRELSRATAELERAWREYDKLEYDVTVTRNQMQEQLDHLGEVQTESAGIQRAQIQ 862

  Fly   208 HDFYKIMRLV-------LIRGTV----------------REELSVKPVTLVAIITLCLRPLIDGN 249
            .:.::|..::       ..|||.                .||..|.|.          ||.:..:
Human   863 KELWRIQDVMEGLSKHKQQRGTTEIGMIGSKPFSTVKYKNEEEEVVPP----------RPPLPRS 917

  Fly   250 FSRNLLAKFLSEILSVPALIYHLQQSVPQCLEQFSSMGLL------------KKALSISGDVQWF 302
            :.      |..:...:|.|        |.     .|..||            ||...:.|..:..
Human   918 YD------FTEQPPIIPPL--------PS-----DSSSLLCYSRGPVHLPEEKKMYQVQGYPRNG 963

  Fly   303 EEFGTSMPGTKSLAFLGNIVNLFNIDGQGESKELAYPLLTETTTSLLE-------LIP------- 353
            ...|......||...|..:..:...:|:.:|:.     ::|..||:::       ::|
Human   964 SHCGPDYRLYKSEPELTTVAEVDESNGEEKSEP-----VSEIETSVVKGSHFPVGVVPPRAKSPT 1023

  Fly   354 ---NTVTTKGVFTQWHELLGWHTPGPEPAQNQNVAL---------IKKQFHMLWDHR--CIKLLL 404
               :|:.:.....:..:::...|..|..|..| :.|         :::|...:..|:  |::
Human  1024 PESSTIASYVTLRKTKKMMDLRTERPRSAVEQ-LCLAESTRPRMTVEEQMERIRRHQQACLR--- 1084

  Fly   405 GDLLKQINLNYERIEFQSPQQPSISNLLRRALERSSTRGVNLMGVASSKQSKQQWRKLDSA---- 465
               .|:..||......|||.| |.|||.......:.||             ::..::||:|
Human  1085 ---EKKKGLNVIGASDQSPLQ-SPSNLRDNPFRTTQTR-------------RRDDKELDTAIREN 1132

  Fly   466 -----------EVVQVSRICGMYYAALNTLSQMKLDILTGICYSDNVLYDIWLLITSLGPNCGMK 519
                       |:||           |.......:|....:..::|:.|:   ::....|| |:.
Human  1133 DVKPDHETPATEIVQ-----------LKETEPQNVDFSKELKKTENISYE---MLFEPEPN-GVN 1182

  Fly   520 EYLELLKSETNLQKPQTAMLMLFCDCMTHYVTILDEHEMYT-----EQNP 564
            . :|::..|.|..|            |...||...:.|..|     |::|
Human  1183 S-VEMMDKERNKDK------------MPEDVTFSPQDETQTANHKPEEHP 1219

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID
CG5087	NP_648279.1	HECTc	694..1076	CDD:238033
CG5087	NP_648279.1	HECTc	718..1075	CDD:214523
PLEKHA5	NP_001243399.1	WW	12..41	CDD:278809
		WW	58..87	CDD:278809
		PH_PEPP1_2_3	164..267	CDD:270068
		PH	170..266	CDD:278594
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900