Protein Alignment CG5087 and Wwc2

DIOPT Version :9

• Sequence 1: NP_648279.1
• Gene: CG5087 / 39035
• FlyBaseID: FBgn0035953
• Length: 1078
• Species: Drosophila melanogaster
• Sequence 2: NP_598552.2
• Gene: Wwc2 / 52357
• MGIID: 1261872
• Length: 1187
• Species: Mus musculus
• Alignment Length: 600
• Identity: 113/600 - (18%)
• Similarity: 193/600 - (32%)
• Gaps: 218/600 - (36%)

  Fly   250 FSRNLLAKFLSEILSVPALI-------YHLQQSVPQCLEQF-------------------SSMGL 288
            :..|.....|:|:.|:...|       ..|.||:.:..|:|                   |.:.|
Mouse   213 YELNEAKAILTELKSIRKAISSGEKEKQDLMQSLAKLQERFHLDQNMGSSEPDLRSSPVNSHLSL 277

  Fly   289 LKKAL------SISGDVQWFEEFGTSMPGTKSLAFLGNIVNLFNIDGQGESKELAYPLLTETTTS 347
            .::.|      |||||:           |.:|.:.|...|.|          .|.|.....:..:
Mouse   278 SRQTLDAGSQTSISGDI-----------GVRSRSNLAEKVRL----------SLQYEEAKRSMAN 321

  Fly   348 L-LELIPNTVTTKGVFTQWHELLGWHTPGPEPAQNQNVALIKKQFHMLWDHRCIKLLLGDLLKQI 411
            | :||              .:|.|...||....:.:.:.||.::              .:|||:
Mouse   322 LKIEL--------------SKLDGEAWPGALDIEKEKLMLINEK--------------EELLKE- 357

  Fly   412 NLNYERIEFQSPQQPSISNLLRRALERSSTRGVNLMGVASS------------KQSKQQWRKLDS 464
                  ::|.:||:.|...|.|...||.... ..||....|            ::.|:..:||:
Mouse   358 ------LQFITPQKRSQEELERLEAERQHLE-EELMAARGSPSRALTERLKLEEKRKELLQKLE- 414

  Fly   465 AEVVQVSRICGMYYAALNTLSQMKLDILTGICYSDNVLYDIWLLITSLGPNCGMKEYLELLKSET 529
                :.:::....|:.|.:||...|.:.:|               :|||         .|..|..
Mouse   415 ----ETTKLTTSLYSQLQSLSSSTLSMSSG---------------SSLG---------SLASSRG 451

  Fly   530 NLQKPQTAMLMLFCDCMTHYVTILDEHEM-YTEQNPFKLNDYVLLTYFLNNILYK---------- 583
            :|.......|           ..|...|: |:.|......||   .|.|:.:|.:
Mouse   452 SLNTSSRGSL-----------NSLSSSELYYSSQGDQMDTDY---QYKLDFLLQEKGGYIPSGPI 502

  Fly   584 -LINDNLLAGAKNIVQHP------------VFLSLHTLML--------CLYRRDCRRPFTPP--- 624
             .|::|      .:|:.|            |..|.||..|        .|..|......:||
Mouse   503 TTIHEN------EVVKSPSQPGQSGLCGVGVTASSHTTPLTEASKSVASLSSRSSLSSLSPPGSP 561

  Fly   625 ----------KHWLIPEVKPSTFINDLEKAKRNAMLLLAKMPHIIPHE----DRVKLFRKFVQN- 674
                      .|...|...|:.| .|.|.::|.|.:.|.:...::..:    .:..|..|.:.:
Mouse   562 LVLDSVFPGSSHDTSPHQFPTDF-EDCELSRRFADVGLGENQALLDSDSGGASQPLLEDKGLSDC 625

  Fly   675 --EKAVMGLTESACASPRSALIVIHRDRIVEDGYRQLAAQPTQALKGVIRVRFINQQGLHEAGID 737
              |....|.|:...:.|:...:.:..|:..    |..||...:::.|        ..|::||.:.
Mouse   626 PGELLCEGATDVEKSLPKRRGLHLRGDKTT----RVSAAASDESVAG--------DSGVYEASMK 678

  Fly   738 QDGVFKE--FLEETI 750
            |.|..::  :.||.:
Mouse   679 QPGEMEDVPYSEEDV 693

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG5087	NP_648279.1	HECTc	694..1076	CDD:238033	12/58 (21%)
		HECTc	718..1075	CDD:214523	8/34 (24%)
Wwc2	NP_598552.2	WW	12..41	CDD:278809
		WW	59..88	CDD:278809
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	438..464		8/60 (13%)
		C2_Kibra	699..822	CDD:176062
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	830..849
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	874..963
		Phage_Nu1	<1088..>1146	CDD:294991

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900