DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5087 and UBR5

DIOPT Version :9

Sequence 1:	NP_648279.1	Gene:	CG5087 / 39035	FlyBaseID:	FBgn0035953	Length:	1078	Species:	Drosophila melanogaster
Sequence 2:	NP_056986.2	Gene:	UBR5 / 51366	HGNCID:	16806	Length:	2799	Species:	Homo sapiens

Alignment Length:	1231	Identity:	231/1231 - (18%)
Similarity:	380/1231 - (30%)	Gaps:	465/1231 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 AQNQKASFLEQTKAAREE---RALEKRREQAAILLQSTLKGYAARRKYQKRIILDFDAMFTENHD 64
            :||   |...:...||||   |.||.||.  |.||.:.....:||..:     |::......:|:
Human  1875 SQN---SARRERMTAREEASLRTLEGRRR--ATLLSARQGMMSARGDF-----LNYALSLMRSHN 1929

  Fly    65 DKDAELELVASNVYPVLRRYLTQIRLDKSDVRARERLERICR---YIIKAMESENTKLSYAALCL 126
            |:.       |:|.|||            ||.:.:.:..:.:   |.|||| ::.|.|....|..
Human  1930 DEH-------SDVLPVL------------DVCSLKHVAYVFQALIYWIKAM-NQQTTLDTPQLER 1974

  Fly   127 FKERSLPWIAHIKILLTN-------------CLTL-------LPELKPENH-----ADSLSLALF 166
            .:.|.|     :::.:.|             ..||       ||....:||     :||::   |
Human  1975 KRTREL-----LELGIDNEDSEHENDDDTNQSATLNDKDDDSLPAETGQNHPFFRRSDSMT---F 2031

  Fly   167 LHTLVVFTAPKSWAILRNAQFEKLQPAMQKICCNIQGHLVQHDFYKIMRLVLIRGTVREELSVKP 231
            |..:    .|..:.:          |..:.|....|.||:|.:..|            |:|..:|
Human  2032 LGCI----PPNPFEV----------PLAEAIPLADQPHLLQPNARK------------EDLFGRP 2070

  Fly   232 VTLVAIITLCLRPLIDGNFSRNLLAKFLSEILSVPALIYHLQQSVPQCLEQFSSMGLLKKALSIS 296
                               |:.|               |....|..:||            :.::
Human  2071 -------------------SQGL---------------YSSSASSGKCL------------MEVT 2089

  Fly   297 GDVQWFEEFGTSMPGTKSLAFLGNIVNLFNIDGQGESKELAYPLLTETTTSLLELIPNTVTTKGV 361
            .|....|...|.|      ::..|:.|:.|:..:.:.:....|:|.|.|.|
Human  2090 VDRNCLEVLPTKM------SYAANLKNVMNMQNRQKKEGEEQPVLPEETES-------------- 2134

  Fly   362 FTQWHELLGWHTPGPEPAQNQNVALIKKQFHMLWDHRCIKLLLGDLLKQINLNYERIEFQSPQ-- 424
                      ..|||..                  |.....|...||.:|.|.    |.:.|.
Human  2135 ----------SKPGPSA------------------HDLAAQLKSSLLAEIGLT----ESEGPPLT 2167

  Fly   425 --QPSISNLLRRALERSSTRGVNLMGVASSKQSKQQWRKLDSAEVVQVSRICGMYYAALNTLSQM 487
              :|..|                .||:                 |:....:.|.:..:|.
Human  2168 SFRPQCS----------------FMGM-----------------VISHDMLLGRWRLSLE----- 2194

  Fly   488 KLDILTGICYSDNVLYDIWLLITSLGPNCGMKEYLELLKSETNLQKPQTAMLMLFCDCMTHYVTI 552
                |.|..:.::|..:...::|.|| ...:|| .:..:....|:..|:..|.|..|
Human  2195 ----LFGRVFMEDVGAEPGSILTELG-GFEVKE-SKFRREMEKLRNQQSRDLSLEVD-------- 2245

  Fly   553 LDEHEMYTEQNPFKLNDY--------------VLLTY---------------------FLNNILY 582
             .:.::..:|...:||::              |.:|:                     ||:|  .
Human  2246 -RDRDLLIQQTMRQLNNHFGRRCATTPMAVHRVKVTFKDEPGEGSGVARSFYTAIAQAFLSN--E 2307

  Fly   583 KLINDNLLAGAKNIVQHPVFLSLHTLMLCLYR------------------------------RDC 617
            ||.|...:..|..        ..||.::...|                              ||.
Human  2308 KLPNLECIQNANK--------GTHTSLMQRLRNRGERDREREREREMRRSSGLRAGSRRDRDRDF 2364

  Fly   618 R-------RPFTP-------------PKH------WLIPEVK--PSTFIND-----LEKAKRNAM 649
            |       |||.|             |.|      .|.|.|:  ...|.:.     ||.:....:
Human  2365 RRQLSIDTRPFRPASEGNPSDDPEPLPAHRQALGERLYPRVQAMQPAFASKITGMLLELSPAQLL 2429

  Fly   650 LLLAKMPHIIPHEDRVKLFRKFVQNEKAVMGLTESACASPRSALIVIH-----RDRIVEDGYRQL 709
            ||||.       ||.::                  |.......||:.|     .|.|::.|....
Human  2430 LLLAS-------EDSLR------------------ARVDEAMELIIAHGRENGADSILDLGLVDS 2469

  Fly   710 AAQPTQALKGVIRVRFINQQGLHEAGIDQDGVFKEFLEETIKKVFDPSLNLFKTTSDQRLYPSPI 774
            :.:..|..:        .:.|...:.:|.|      |::|...  |.:..||.....:..|....
Human  2470 SEKVQQENR--------KRHGSSRSVVDMD------LDDTDDG--DDNAPLFYQPGKRGFYTPRP 2518

  Fly   775 SYVQDNHLELFEFVGRMLGKAVYEGIVVDVPFASFFLSQLLGQTQQALYSCMDELPSLDNELYRS 839
            ....:..|..|..:||:||..:.:..:..:......:..|||:...     ..:....|..:|.|
Human  2519 GKNTEARLNCFRNIGRILGLCLLQNELCPITLNRHVIKVLLGRKVN-----WHDFAFFDPVMYES 2578

  Fly   840 L--TFIKHYKQDV----SDLNLTFSVD---QDVMGKIVTLALHPGGKARVVNDHNKLVYIHYMAF 895
            |  ..:.....|.    |.::|.|::|   ::..|::   .|.|.|....|...|...|:...|.
Human  2579 LRQLILASQSSDADAVFSAMDLAFAIDLCKEEGGGQV---ELIPNGVNIPVTPQNVYEYVRKYAE 2640

  Fly   896 FHMNTQIREQTIAFNRGFRSIVNPEWLSLFSPPELQRLISGDTSPLDLKDLQKHTHYYGGFHDTH 960
            ..|.....:...|..:|...::....|...:..:.:.|::| ...::::.|...|    .|:|..
Human  2641 HRMLVVAEQPLHAMRKGLLDVLPKNSLEDLTAEDFRLLVNG-CGEVNVQMLISFT----SFNDES 2700

  Fly   961 --------QVVCWLWDILAKDFTEEERKLFLKFVTSCSKPPLL--GFAHLEPPFSIRCVEVSDDE 1015
                    |...|.|.|:.| .:..||:..:.|.||....|..  ||..: |..:||   ..||:
Human  2701 GENAEKLLQFKRWFWSIVEK-MSMTERQDLVYFWTSSPSLPASEEGFQPM-PSITIR---PPDDQ 2760

  Fly  1016 DTGDTIGSVIRGFFAIRKKDPLNRLPTSSTCFNLLKLPNYQKKSTLRDKLRYAV-SSNTGF 1075
                                   .|||::||.:.|.:|.|..|..|:.||..|: :.|.||
Human  2761 -----------------------HLPTANTCISRLYVPLYSSKQILKQKLLLAIKTKNFGF 2798

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5087	NP_648279.1	HECTc	694..1076	CDD:238033	85/407 (21%)
CG5087	NP_648279.1	HECTc	718..1075	CDD:214523	77/376 (20%)
UBR5	NP_056986.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	77..175
		CUE_UBR5	184..230	CDD:270606
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	328..352
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	579..648
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	999..1031
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1052..1075
		ZnF_UBR1	1177..1244	CDD:197698
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1299..1318
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1515..1740
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1859..1890		6/17 (35%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1984..2021		6/36 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2117..2142		8/66 (12%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2323..2392		10/68 (15%)
		PolyA	2389..2452	CDD:197769	17/87 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2473..2493		4/33 (12%)
		HECTc	2501..2796	CDD:214523	70/335 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900