DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5087 and HERC5

DIOPT Version :9

Sequence 1:	NP_648279.1	Gene:	CG5087 / 39035	FlyBaseID:	FBgn0035953	Length:	1078	Species:	Drosophila melanogaster
Sequence 2:	XP_011530324.2	Gene:	HERC5 / 51191	HGNCID:	24368	Length:	1100	Species:	Homo sapiens

Alignment Length:	1036	Identity:	222/1036 - (21%)
Similarity:	370/1036 - (35%)	Gaps:	311/1036 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   176 PKSWAILRNAQFEKL-QPAMQKICCNIQGHLVQHDFYKIMRLVLIRGTVREELSVKPVTLVAIIT 239
            ||...:.:|.:...: |.|...:..:..|...::|.|.:..|..  .::.:|..:..:|.....:
Human   239 PKCIKLGKNMKIHSVDQGAEHMLILSSDGKPFEYDNYSMKHLRF--ESILQEKKIIQITCGDYHS 301

  Fly   240 LCLRPLIDGN---FSRNLLA------KFLSEILSVPALIYHLQQSVPQCLEQFSSMGLLKKALSI 295
            |.|..  .|.   :.:||..      ||.|  .:.|.::.|| ..||  |.|.|:......|||:
Human   302 LALSK--GGELFAWGQNLHGQLGVGRKFPS--TTTPQIVEHL-AGVP--LAQISAGEAHSMALSM 359

  Fly   296 SGDV-QWFEEFGTSMPGTKSLAFLGNIVNLFNIDGQGESKELAYPLLTETTTSLLELIPN----- 354
            ||:: .|         |......||.        |..|||:         ..||:|.:.|
Human   360 SGNIYSW---------GKNECGQLGL--------GHTESKD---------DPSLIEGLDNQKVEF 398

  Fly   355 ---------TVTTKGVFTQW----HELLGWHTPGPEPAQNQ-NVALIKKQFHMLWDHRCIKLLLG 405
                     .:|..|:...:    |..||.::     .||: ...|:.:    |..:|..::..|
Human   399 VACGGSHSALLTQDGLLFTFGAGKHGQLGHNS-----TQNELRPCLVAE----LVGYRVTQIACG 454

  Fly   406 ---------DLLK----------QINLNYERIEFQSPQQPSISNLLRRALERSSTRGVNLMGVAS 451
                     ||.|          |:.....|.:.. |....:|:.....|| |.|....|:.:|.
Human   455 RWHTLAYVSDLGKVFSFGSGKDGQLGNGGTRDQLM-PLPVKVSSSEELKLE-SHTSEKELIMIAG 517

  Fly   452 SKQSKQQWRKLDSAEVVQVSRICGMYYAALN--TLSQMKLDILTGICYSDNVLYDIWLLITSLGP 514
            ..||...|.|.::: .|.:.|.    ...||  |:.:...|:.|....|..  .:|..:.:|  |
Human   518 GNQSILLWIKKENS-YVNLKRT----IPTLNEGTVKRWIADVETKRWQSTK--REIQEIFSS--P 573

  Fly   515 NCGMKEYLELLKSETNLQKPQTAMLMLFCDCMTHYVTILDEHEMYTEQNPFKLNDYVLLTY--FL 577
            .|....:|.        ::..|.|:.::.|             :...:|.||     .||.  ::
Human   574 ACLTGSFLR--------KRRTTEMMPVYLD-------------LNKARNIFK-----ELTQKDWI 612

  Fly   578 NNILYKLINDNLLAGAKNIVQHPVFLSLHTLMLCLYRRDCRRPF-TPPKH-----WLIPE----- 631
            .|::...:.||||.                          |.|| :||:.     :|:||
Human   613 TNMITTCLKDNLLK--------------------------RLPFHSPPQEALEIFFLLPECPMMH 651

  Fly   632 ---------------------------------VKPSTF-----------INDL----EKAKRN- 647
                                             ::.|||           |..|    |.|:.|
Human   652 ISNNWESLVVPFAKVVCKMSDQSSLVLEEYWATLQESTFSKLVQMFKTAVICQLDYWDESAEENG 716

  Fly   648 ---AMLLLAKMPHIIPHEDRVKLFRKFVQNEKAVMGLTESACASPRSALIVIHRDRIVEDGYRQL 709
               |:|.:.|..|      |.|..:.:::: .|:....||..|...:..:.:.|:.::||...||
Human   717 NVQALLEMLKKLH------RSKKHKAYLRS-AAIEEERESEFALRPTFDLTVRRNHLIEDVLNQL 774

  Fly   710 AAQPTQALKGVIRVRFINQQGLHEAGIDQDGVFKEFLEETIKKVFDPSLNLFKTTSDQRLYPSPI 774
            :....:.|:..:.|.|..     |.|.|..||.|||......::..|...:|       :||...
Human   775 SQFENEDLRKELWVSFSG-----EIGYDLGGVKKEFFYCLFAEMIQPEYGMF-------MYPEGA 827

  Fly   775 SYVQDNHLELFE-----FVGRMLGKAVYEGIVVDVPFASFFLSQLLGQTQQALYSCMDELPSLDN 834
            |.:.......||     |.|.:.|.:::...|.::||......:||.|...     :::|..|..
Human   828 SCMWFPVKPKFEKKRYFFFGVLCGLSLFNCNVANLPFPLALFKKLLDQMPS-----LEDLKELSP 887

  Fly   835 ELYRSL-------------TFIKHYK--QDVSDLNLTFSVDQDVMGKIVTLALHPGGKARVVNDH 884
            :|.::|             .|..|:.  .|.:|.||.                 |.|.:..||..
Human   888 DLGKNLQTLLDDEGDNFEEVFYIHFNVHWDRNDTNLI-----------------PNGSSITVNQT 935

  Fly   885 NKLVYIHYMAFFHMNTQIREQTIAFNRGFRSIVNPEWLSLFSPPELQRLISGDTSPLDLKDLQKH 949
            ||..|:.....:..|..::.....|.|||..:.:.:.:.||.|.||:.:|.|:|. .|.|..:|:
Human   936 NKRDYVSKYINYIFNDSVKAVYEEFRRGFYKMCDEDIIKLFHPEELKDVIVGNTD-YDWKTFEKN 999

  Fly   950 THYYGGFHDTHQVVCWLWDILAKDFTEEERKLFLKFVTSCSKPPLLGFAHLEPPFSIRCVEVSDD 1014
            ..|..|::.:|..:...|....| .|.||:|.||.|:|...:..:....:::..|   |...|.:
Human  1000 ARYEPGYNSSHPTIVMFWKAFHK-LTLEEKKKFLVFLTGTDRLQMKDLNNMKITF---CCPESWN 1060

  Fly  1015 EDTGDTIGSVIRGFFAIRKKDPLNRLPTSSTCFNLLKLPNYQKKSTLRDKLRYAVSSNTGF 1075
            |                  :||:..|    |||::|.||.|....|:.:.|:.|:::|.||
Human  1061 E------------------RDPIRAL----TCFSVLFLPKYSTMETVEEALQEAINNNRGF 1099

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5087	NP_648279.1	HECTc	694..1076	CDD:238033	98/402 (24%)
CG5087	NP_648279.1	HECTc	718..1075	CDD:214523	90/376 (24%)
HERC5	XP_011530324.2	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810