DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5087 and Wwc2

DIOPT Version :9

Sequence 1:	NP_648279.1	Gene:	CG5087 / 39035	FlyBaseID:	FBgn0035953	Length:	1078	Species:	Drosophila melanogaster
Sequence 2:	NP_001102581.1	Gene:	Wwc2 / 498630	RGDID:	1559427	Length:	1194	Species:	Rattus norvegicus

Alignment Length:	742	Identity:	137/742 - (18%)
Similarity:	246/742 - (33%)	Gaps:	237/742 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   177 KSWAILRNAQFEKLQPAMQKICCNIQGHLVQHDFYKIMRLVLIRGTVREELSVKPVTLVAIITLC 241
            |...:.:...||.||...:|:.....|:                     |||.....|..:.::
  Rat   186 KQELLYKQQGFETLQQIDEKMSGGQSGY---------------------ELSEAKAILTELKSI- 228

  Fly   242 LRPLIDGNFSRNLLAKFLSEILSVPALIYHLQQSVP------QCLEQFSSMGLLKKAL------S 294
            .:.:..|...:..|.:.|:::..    .:||.|::.      :|....|.:.|.::.|      |
  Rat   229 RKAISSGEKEKQDLMQSLAKLQE----RFHLDQNMGSSEPDLRCSPVNSHLSLSRQTLDAGSQTS 289

  Fly   295 ISGDVQWFEEFGTSMPGTKSLAFLGNIVNLFNIDGQGESKELAYPLLTETTTSL-LELIPNTVTT 358
            ||||:           |.:|.:.|...|.|          .|.|.....:..:| :||
  Rat   290 ISGDI-----------GVRSRSNLAEKVRL----------SLQYEEAKRSMANLKIEL------- 326

  Fly   359 KGVFTQWHELLGWHTPGPEPAQNQNVALIKKQFHMLWDHRCIKLLLGDLLKQINLNYERIEFQSP 423
                   .:|.|...||....:.:.:.||.::              .:|||:       ::|.:|
  Rat   327 -------SKLDGEAWPGALDVEKEKLMLINEK--------------EELLKE-------LQFITP 363

  Fly   424 QQPSISNLLRRALERS-------STRGVNLMGVAS----SKQSKQQWRKLDSAEVVQVSRICGMY 477
            |:.:...|.|...||.       :.||:....:|.    .::.|:..:||:     :.:::....
  Rat   364 QKRTQDELERLEAERQRLEEELVAARGLPSRALAERLKLEEKRKELLQKLE-----ETTKLTTYL 423

  Fly   478 YAALNTLSQMKLDILTGICYSDNVLYDIWLLITSLGPNCGMKEYLELLKSETNLQKPQTAMLMLF 542
            |:.|.:||...|.:.:|               :|||         .|..|..:|.......|...
  Rat   424 YSQLKSLSSSTLSMSSG---------------SSLG---------SLASSRGSLNTSSRGSLNSL 464

  Fly   543 CDCMTHYVTILDEHEMYTEQNPFKLNDYVL-----------LTYFLNNILYKLINDNLLAGAKNI 596
            .....:|.:..|  :|.|:.. :|| |::|           :|....|   :::......|...:
  Rat   465 SSSDLYYSSQGD--QMDTDYQ-YKL-DFLLQEKGGYIPSGPITTIHEN---EVVKSPSQPGQSGL 522

  Fly   597 VQHPVFLSLHTLML--------CLYRRDCRRPFTPPKHWLI---------PEVKPSTFINDLEKA 644
            ....|..:.||..|        .|..|......:||...|:         .:..|..|..|||..
  Rat   523 CGLGVAATSHTPPLTEASKSVTSLSSRSSLSSLSPPGSPLVLDSTFPGSSHDTSPHQFTADLEDC 587

  Fly   645 K-----------RNAMLLLAKM--PHIIPHEDRVKLFRKFVQNEKAVMGLTESACAS-----PRS 691
            :           .|.:||.:..  |.....||:        ..::...||.....|.     |:.
  Rat   588 ELSRHFADIGLGENQVLLDSDSGGPSQSLLEDK--------DLDECTGGLLYEGSADVEKSLPKR 644

  Fly   692 ALIVIHRDRIVEDGYRQLAAQPTQALKGVIRVRFINQQGLHEAGIDQDGVFKE--FLEE--TIKK 752
            ..:.:..|:..    |..||...:::.|        ..|::||.:.|.|..::  :.||  ||.:
  Rat   645 RGLHLRGDKTA----RVSAAASDESVAG--------DSGVYEASVKQPGEIEDIPYREEDVTIVE 697

  Fly   753 VFDPSLNL-FKTTSDQRLYPSPISYVQDNHLELFEFVGRMLGKAVYEGIVV-----DVPFASFFL 811
            .....:.| :.|.|...:    :...|..:|..|....   ...||..:.|     ||  :..|.
  Rat   698 TAQVQIGLRYDTKSSSFM----VIIAQLRNLHAFSIPH---SSKVYFRVAVLPSSADV--SCLFR 753

  Fly   812 SQLLGQTQQALYSCMDELPSLDNELYR 838
            :::...|:..||          |:::|
  Rat   754 TKVHPPTESVLY----------NDVFR 770

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5087	NP_648279.1	HECTc	694..1076	CDD:238033	31/155 (20%)
CG5087	NP_648279.1	HECTc	718..1075	CDD:214523	27/131 (21%)
Wwc2	NP_001102581.1	WW	12..41	CDD:278809
		WW	59..88	CDD:278809
		DUF342	<283..385	CDD:302792	31/157 (20%)
		YlqD	351..>420	CDD:287979	16/94 (17%)
		C2_Kibra	699..822	CDD:176062	17/91 (19%)
		Phage_Nu1	<1095..>1153	CDD:294991
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900