DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5087 and ctrip

DIOPT Version :9

Sequence 1:	NP_648279.1	Gene:	CG5087 / 39035	FlyBaseID:	FBgn0035953	Length:	1078	Species:	Drosophila melanogaster
Sequence 2:	NP_001189170.1	Gene:	ctrip / 40596	FlyBaseID:	FBgn0260794	Length:	3140	Species:	Drosophila melanogaster

Alignment Length:	926	Identity:	199/926 - (21%)
Similarity:	325/926 - (35%)	Gaps:	306/926 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   377 EPAQNQNVA---LIKKQFHMLWDHRCIKLLLGDLLKQINLN-YERIEFQSP---QQPSISN---- 430
            |...:.|||   |.:..|.    |: ::..:||.:...|:. |:.::..||   :||...|
  Fly  2297 EEDMDDNVAAVVLSQASFR----HK-LQFTIGDHVLPYNMTVYQAVKQFSPLVSEQPETDNESET 2356

  Fly   431 -------------LLRRALERSSTRGVNLMGVASSKQS------KQQWRKLDSAEVVQVSRICGM 476
                         :..|.:|...|.|. ..|.|||..|      |||.....::..|..:..|..
  Fly  2357 LLGNASIWVQQHTIHYRPVEEEVTSGA-AAGAASSSSSCSSGVQKQQSSSSSASSCVNATSSCSS 2420

  Fly   477 YYAALNTLSQMKLDILTGICYSDNVLY-----DIW------LLITSLGPNCGMKEYLELLKSE-- 528
            .....:....     ||...:..:..:     ::|      ::|::|.|         .|.|.
  Fly  2421 SSGVASGGGS-----LTKKAHKSSSKFMRKKTELWHEGIAPVVISALKP---------FLSSSLP 2471

  Fly   529 TNLQKPQTAMLMLFCDCMTHYVTILDEH--EMY---TEQNPFKLNDYVLLTYFLNNILYKLINDN 588
            .::...|.|.|...  ||...:..|:.|  .:|   ..||....:|:              |:..
  Fly  2472 ADVVTVQDASLDAL--CMLRVIHALNRHWDHLYGCVVRQNIIPQSDF--------------IHPK 2520

  Fly   589 LLAGAKNIVQHPVFLSLHTLMLCLYRRDCRRPFTPP---KHWL--------------IPEVKPST 636
            ::|.|...:|.|:.:....|...|.:.....||..|   :|.|              :.:..|.
  Fly  2521 IMAKANRQLQDPLVIMTGNLPQWLPQIGMACPFLFPFETRHLLFYATSFDRDRALQRLLDTTPD- 2584

  Fly   637 FINDLEKAKRNAMLL------------LAKMPHI------------IPHEDRV------------ 665
             :|..|.::|.|..|            |.:..||            |.:|:.|
  Fly  2585 -LNAAESSERVAPRLDRRKRAISRTEILKQAEHILQDFGHSKALLEIQYENEVGTGLGPTLEFYA 2648

  Fly   666 ----KLFRKFV---------------------------------------QNEKAVMG---LTES 684
                :|.|..:                                       ||..||.|   ::.|
  Fly  2649 LVSAELQRTDLGLWNGSDSYKQNSVTIVDVVKANSAVLHIEDALEATTTDQNTPAVAGASLVSSS 2713

  Fly   685 ACASPRSALIVIH-------RDRIVEDGYRQLAAQPTQ-----------ALKGVIRVRFINQQGL 731
            ...:..:|....|       |..::..|..|   ||.:           ||..||..:|.:....
  Fly  2714 TTTTTTTAQQHQHPPTRSSSRSHVLRSGAGQ---QPVEHSSSSAGANENALNMVIAQQFSDTNSA 2775

  Fly   732 HEAGIDQDGVFKEFLEETIKKVFDPSLNLFKTTSDQR------------------------LYPS 772
            :.|.||                 :||.....||..|.                        |:|.
  Fly  2776 NPAAID-----------------NPSSTTTATTVVQHNTTTNNSSIITTTTTTSYVHAVHGLFPL 2823

  Fly   773 PISYVQDNHL-------ELFEFVGRMLGKAVYEGIVVDVPFASFFLSQLLGQTQQ-ALYSCMDEL 829
            |:.  :.:.|       ..|:|:|:.:.|||.:..::|:||:..|...|:.:... .|...|...
  Fly  2824 PLG--KSSKLPQMTKAKAKFKFLGKFMAKAVMDSRMLDLPFSLPFYRWLVSEEHSIGLADLMRVA 2886

  Fly   830 PSLDNELYRSLTFIKHYKQDVSDLNL-----TFSVDQ-DVMG-KIVTLAL------HP------G 875
            |.:.|.|.|....::..:..:||.|:     |..::| |:.| .|..|.|      |.      |
  Fly  2887 PEVQNTLVRLQDLVRQREYILSDPNIDAMEKTEKIEQLDLDGCPIADLGLDFVLPGHANIELCRG 2951

  Fly   876 GKARVVNDHNKLVYIHYMAFFHMNTQIREQTIAFNRGFRSIVNPEWLSLFSPPELQRLISGDTSP 940
            |:...|..||...||..:.::.:...:::|..|...||.|:...:.|.:|.|.||:.:..|..|.
  Fly  2952 GRDTPVTVHNLHQYISLVTYWFLIEGVQKQFEALREGFDSVFPIQRLRMFYPEELECVFCGSGSE 3016

  Fly   941 -----LDLKDLQKHTHYYGGFHDTHQVVCWLWDILAKDFTEEERKLFLKFVTSCSKPPLLGFAHL 1000
                 .::|.||:......|||...|.:.:|::||| .:..:|::.||:|||...:.|..||..|
  Fly  3017 QQHSRWEIKMLQESCRTDHGFHQDSQAIQYLYEILA-SYNRDEQRAFLQFVTGSPRLPTGGFKAL 3080

  Fly  1001 EPPFSIRCVEVSDDEDTGDTIGSVIRGFFAIRKKDPLNRLPTSSTCFNLLKLPNYQKKSTLRDKL 1065
            .||.:|  |..:.||:                 ::|.:.||:..||.|.||||:|..:..:|.||
  Fly  3081 TPPLTI--VRKTLDEN-----------------QNPNDYLPSVMTCVNYLKLPDYSSREVMRQKL 3126

  Fly  1066 RYAVSSNTG---FELS 1078
            :  |::|.|   |.||
  Fly  3127 K--VAANEGSMSFHLS 3140

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5087	NP_648279.1	HECTc	694..1076	CDD:238033	114/458 (25%)
CG5087	NP_648279.1	HECTc	718..1075	CDD:214523	106/415 (26%)
ctrip	NP_001189170.1	Extensin_2	<688..731	CDD:252669
		WWE	1409..1481	CDD:128922
		FAM199X	<1985..2074	CDD:292442
		HECTc	<2818..3138	CDD:294058	95/343 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.900