DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5087 and Ube3a

DIOPT Version :9

Sequence 1:	NP_648279.1	Gene:	CG5087 / 39035	FlyBaseID:	FBgn0035953	Length:	1078	Species:	Drosophila melanogaster
Sequence 2:	NP_648452.1	Gene:	Ube3a / 39266	FlyBaseID:	FBgn0061469	Length:	973	Species:	Drosophila melanogaster

Alignment Length:	958	Identity:	202/958 - (21%)
Similarity:	370/958 - (38%)	Gaps:	283/958 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   265 VPALIYHLQQSVPQCLEQFSSMGLLKKALSISGDVQWFEEFGTSMPGTKSLAFL-----GNIVNL 324
            ||....:|.|||||              |.|:|..   ...|.|.|.|.:||.:     .:::.|
  Fly   149 VPVSSPYLTQSVPQ--------------LDIAGAE---HSSGDSEPCTPTLAPVHSLDANSLIAL 196

  Fly   325 F---------------------NIDGQGES-KELAYPLLTETTTSLLELIPNTVTTKGVFTQWHE 367
            :                     ::|..|:| ...|.|   ..::||.||:.|
  Fly   197 YEQCRAADSYDRICHAIGVVFSSVDRLGKSFIRSAEP---AASSSLQELLAN------------- 245

  Fly   368 LLGWHTPGPEPAQNQNVALIKKQFHMLWDHRCIKLLLGDLLKQINLNYERIEFQSPQQPSISNLL 432
                 :||         ||.|:|                 |:.:...:::.| .|.||
  Fly   246 -----SPG---------ALNKEQ-----------------LRTLEGEHDKDE-DSTQQ------- 271

  Fly   433 RRALERSSTRGVNLMGVASSKQSKQQWRKLD-------SAEVV-------QVSRICGMYYAALNT 483
               ::..|....|....|.|.:|:.:..:.|       |::.:       :|.|:  ::...:..
  Fly   272 ---VDEQSESAANATATAESVESEAEPEEEDDDVCSSQSSDTLVDLPGLRRVQRL--LFGCQIRA 331

  Fly   484 LSQMKLDILTG--ICYSDNVLY--DIW-------LLITSLGPNCGMK----EYLE-----LLKSE 528
            :::.    ||.  |..||.|:|  ..|       ::...|..|....    :||:     |.::.
  Fly   332 ITEK----LTSSVIQLSDWVIYMRTDWERVIHCLVICFDLATNTNNSVVDMDYLDRVLPKLCQAA 392

  Fly   529 TNLQKPQTAML----MLFCDCMTHYV-----------TILDEHEMYTEQNPFKLNDYVLLTYFLN 578
            :.:..|..|.|    ...|....|.:           .:|||..|...::...:...:.:.::.|
  Fly   393 SAMPVPAQARLARIWAAHCSDQLHSLIAACQQQITLQVLLDEESMRENESIISVTKVLKIVFYAN 457

  Fly   579 NILYKL-----------------------INDNLLAGAKNIVQH-PVF--------LSLHTLMLC 611
            .:..:|                       :.|:|......:..| |.|        |.:..:
  Fly   458 ILASELERPSCRVPLEDRTEAATASGSAAVEDDLFVYNSLLEPHMPKFAEDQFEKELQVSAI--- 519

  Fly   612 LYRRDCRRPFTPPKHWLIPEVKPSTFI-NDLEKAKRNAM------------------LLLAKMPH 657
                |||:|..|.:.:....:..:..: :|....|..||                  .:|.....
  Fly   520 ----DCRKPLIPLEEFYNEALSENIQMHHDYLSYKTLAMESEIGSGHANYFSFMLYAFILTPSTK 580

  Fly   658 I--IPHEDRVKLFRK------FVQNEKAVMGLTESACASPRSAL-IVIHRDRIVED---GYRQLA 710
            :  :.::.|::::.:      .:.|....:|..:    :||..| :.:.||:::.|   |...:|
  Fly   581 VDALYYDSRMRMYSERYSSLHSILNNIGQVGQED----NPRPDLKLTVRRDQLINDALIGLEMVA 641

  Fly   711 AQPTQALKGVIRVRFINQQGLHEAGIDQDGVFKEFLEETIKKVFDPSLNLF---KTTSDQRLYPS 772
            ....:.||..:.|.|:.:|     |||:.||.|||.:..::::|:|:..:|   :.|::.....:
  Fly   642 MSNPKDLKKQLVVEFVGEQ-----GIDEGGVSKEFFQLIVEEIFNPAFGMFIQQEETNNMWFNAT 701

  Fly   773 PISYVQDNHLELFEFVGRMLGKAVYEGIVVDVPFASFFLSQLLGQTQQALYSCMDELPSLDNELY 837
            |.    :|..: |..:|.::|.|:|..:.:.|.|......:|:|..     ....:|......||
  Fly   702 PF----ENGAQ-FTLIGIIIGLAIYNNVTLAVNFPMVVYRKLIGYC-----GTFADLSDWSPALY 756

  Fly   838 RSLTFIKHYK-QDVSDL-NLTFSVD-QDVMGKIVTLALHPGGKARVVNDHNKLVYIHYMAFFHMN 899
            :||..:..|: ||:.:: ..||.:. .||.|.:|...|.|.|:..:|..|||.::::..:.|.:|
  Fly   757 KSLKSMLDYQGQDMEEVFEQTFKISYSDVFGDVVQHELVPNGQDVLVGQHNKELFVNLYSDFLLN 821

  Fly   900 TQIREQTIAFNRGFRSIVNPEWLS-LFSPPELQRLISGDTSPLDLKDLQKHTHYYGGFHDTHQVV 963
            |.|.:|..||.:||..:.:...|. ||.|.|::.|:.| :...|..:|:..|.|.||:.:..|.:
  Fly   822 TNIEQQFNAFRKGFEMVTDESPLKLLFRPEEIEMLVCG-SREFDFVELENSTVYEGGYTEKSQYI 885

  Fly   964 CWLWDILAKDFTEEERKLFLKFVTSCSKPPLLGFAHLEPPFSIRCVEVSDDEDTGDTIGSVIRGF 1028
            ...|.|:....:|::.|| |:|.|..::.|:.|         ::|:.:
  Fly   886 QDFWSIVHAMPSEDKHKL-LEFTTGSARVPVGG---------LKCLRL----------------- 923

  Fly  1029 FAIRKKDP-LNRLPTSSTCFNLLKLPNYQKKSTLRDKLRYAVSSNTGF 1075
             .|.:..| .:|||||.||||:|.||.|..:..|.::|..|::.:.||
  Fly   924 -LITRHGPDSDRLPTSHTCFNVLLLPEYSSREKLEERLMKAINYSKGF 970

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5087	NP_648279.1	HECTc	694..1076	CDD:238033	108/393 (27%)
CG5087	NP_648279.1	HECTc	718..1075	CDD:214523	100/364 (27%)
Ube3a	NP_648452.1	AZUL	40..94	CDD:293166
		HECTc	620..971	CDD:238033	109/395 (28%)
		HECTc	647..970	CDD:214523	101/366 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45446972
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.740