Protein Alignment CG5087 and Herc4

DIOPT Version :10

• Sequence 1: NP_648279.1
• Gene: CG5087 / 39035
• FlyBaseID: FBgn0035953
• Length: 1078
• Species: Drosophila melanogaster
• Sequence 2: NP_001261249.1
• Gene: Herc4 / 38151
• FlyBaseID: FBgn0035207
• Length: 1062
• Species: Drosophila melanogaster
• Alignment Length: 1121
• Identity: 228/1121 - (20%)
• Similarity: 399/1121 - (35%)
• Gaps: 321/1121 - (28%)

  Fly   168 HTLVVFTAPKSWAILRNAQFEKL-------QPAMQ--------------KICCNIQGHLVQHDFY 211
            |||.:....|.:|...| .:.:|       :|.|.              :|||..:..|...|:.
  Fly    51 HTLFLTATGKVYACGSN-DYSQLGHDLPTKRPRMSPFLLIPELQDYVIIQICCGSRHSLALSDWG 114

  Fly   212 KIM----------------RLVLIRGTVREELSVKPVTLVAIITLCLRPLIDGNFSRNLLAKFLS 260
            :::                .:|.:...|| :|..|.|..:|    |      || :.:|......
  Fly   115 QVLSWGDNDCGQLGHATDKEIVQLPKVVR-QLVTKTVVQIA----C------GN-NHSLALTSCG 167

  Fly   261 EILSVPALIY-----HLQQSVPQC---LEQFSSMGLLKKALSISGDVQWF--------------- 302
            |:.|..:.||     :....:..|   |...:.:|:...|::..|:..:.
  Fly   168 ELYSWGSNIYGQLGVNSPNDLTHCNYPLRLTTLLGIPLAAIACGGNHSFLISKSGAVFGWGRNNC 232

  Fly   303 ------EEFGTSMP----------------GTKSLAFLGNIVNLFNID-------GQGESKELAY 338
                  :|...|.|                |.:...||.|...:|...       |.|.|.....
  Fly   233 GQLGLNDETNRSYPTQLKTLRTLGVRFVACGDEFSVFLTNEGGVFTCGAGAYGQLGHGFSSNEML 297

  Fly   339 P-----LLTETTTSL-------LELIPN----------------TVTTKGVFTQWHELLGWHTPG 375
            |     |:..|.|.:       |.|:|:                |.:||.:......:..|.:|.
  Fly   298 PRMVMELMGSTITQVACGNRHTLALVPSRGRVYAFGLGSSGQLGTRSTKSLMLPQVVIGPWVSPS 362

  Fly   376 PEPAQNQN---VALIKKQFHMLWDHRCI--KLLLGDLLKQINLNYERIEFQSPQQPSISNLLRRA 435
            .......|   |:|:.:|.....|...:  .|.:..:..:...||      :|:    |.:|...
  Fly   363 GSALLQSNDSQVSLVIRQIFSGGDQSIVTTTLFVDKVPPEDFRNY------NPK----SQILTLT 417

  Fly   436 LERSSTRGVNLMGVASSKQSKQ-QWRKLDSAEVVQVSRIC--------------------GMYYA 479
            .|.:..       .|..||..| ....|.|.|::..|:.|                    |:...
  Fly   418 AEVTKQ-------CAQCKQGLQSDMDLLSSIELIFRSQACWNGSFLLDHDRHFGCSVRNHGLDLK 475

  Fly   480 ALNTLSQMKLDILTGICYSDNVLYDIWLLITSLGPNCGMKEYL-ELLKSETNLQKPQTAMLM-LF 542
            |    :|:..|.|..: .::::...||..||        ||.: .|:.|..:::..:..:|: |:
  Fly   476 A----AQLAFDNLRAV-ENESIRQVIWDNIT--------KELVGSLVCSPADVESMRLYLLLPLY 527

  Fly   543 CDCMT--HYVTILDEHEMYTEQNPFKLNDYVLLTYFLNNILYKL-------INDNLLAGAKNIVQ 598
            .:.:.  ||.::         |.||.            |.::||       :|..|........:
  Fly   528 HEFVNSKHYKSL---------QVPFA------------NAIFKLAENPRKVLNKWLAQTPAEYFE 571

  Fly   599 HPVFLSLHTLMLCL-------------YRRDCRRPFTPPKHWLIPEVKPSTFINDLEKAKRNAML 650
            |.|...||.::..:             .||....|:......::..:|....||:....:.|..:
  Fly   572 HLVQNFLHVVIHIISFKMGLAAASPSAERRQQLLPYNTELEIILKLMKTLCQINNERHDRLNYQI 636

  Fly   651 LLAKMPHIIPHEDRVKLFRK----------------FVQNEKAVMGLTE--------SACAS--- 688
            ..  .|.:..:.|..:.:.|                |:.::.|...|.:        ||.|:
  Fly   637 FY--WPDLSDYADVQQEYVKWIMADTARDFNICNYSFIFDQSAKTALLQADQALQMHSAMANAAT 699

  Fly   689 ----------PRSALIVIH--RDRIVEDGYRQLAAQPTQALKGVIRVRFINQQGLHEAGIDQDGV 741
                      |.|..||::  |:.:|:|..|:|.......||..::::|..::. .:||    ||
  Fly   700 MAFSFFNYGMPISQFIVLNVTRENLVQDSLRELQHYSQSDLKKPLKIKFHGEEA-EDAG----GV 759

  Fly   742 FKEFLEETIKKVFDPSLNLFKTTSDQR-LYPSPISYVQDNHLELFEFVGRMLGKAVYEGIVVDVP 805
            .|||....:|.:.||...:||.....| |:.:.:::..:|   ::..:|.:.|.|:|...::::|
  Fly   760 RKEFFMLLLKDLLDPKYGMFKEYEQSRLLWFADLTFETEN---MYFLIGVLCGLAIYNFTIINLP 821

  Fly   806 FASFFLSQLLGQTQQALYSCMDELPSLDNELYRSLTFIKHYKQD----VSDLNLTFSVDQDVMGK 866
            |......:|||:...     :.:|..|......|:..:..|:.|    |.|  |||.:.:||.|:
  Fly   822 FPLALFKKLLGKPVD-----LSDLRQLSPPEANSMQSLLDYQGDDFKEVFD--LTFEISRDVFGE 879

  Fly   867 IVTLALHPGGKARVVNDHNKLVYIHYMAFFHMNTQIREQTIAFNRGFRSIVNPEWLSLFSPPELQ 931
            ..|..|.|.|....|...|:..::.....|..|..:.....||::||..:.:...:.:|.|.||.
  Fly   880 AETKCLKPNGNEIAVTLENRQEFVDLYVDFVFNKSVELHYNAFHKGFMKVCSGRVIHIFQPEELM 944

  Fly   932 RLISGDTSPLDLKDLQKHTHYYGGFHDTHQVVCWLWDILAKDFTEEERKLFLKFVTSCSKPPLLG 996
            .::.|: ...|.:.||.:..|..|:......:.|.|::: .|.:|.|:|.||.|:|...:.|:.|
  Fly   945 AVVVGN-EDYDWQALQDNCEYREGYTSVDDTIKWFWEVI-HDMSEAEKKSFLLFLTGSDRIPIQG 1007

  Fly   997 FAHLEPPFSIRCVEVSDDEDTGDTIGSVIRGFFAIRKKDPLNRLPTSSTCFNLLKLPNYQKKSTL 1061
            ...|:     ..::.:.||                      ..||.:.||||||.||.|:.|..|
  Fly  1008 MKALK-----LTIQPTPDE----------------------RFLPVAHTCFNLLDLPRYKTKERL 1045

  Fly  1062 RDKLRYAVSSNTGFEL 1077
            :.||..|:....||.|
  Fly  1046 KYKLLQAIQQTQGFSL 1061

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG5087	NP_648279.1	IQCD	20..50	CDD:467745
		HECTc	694..1076	CDD:238033	101/388 (26%)
Herc4	NP_001261249.1	ATS1	7..352	CDD:444065	55/313 (18%)
		RCC1	327..390	CDD:395335	10/62 (16%)
		HECTc	715..1060	CDD:238033	101/388 (26%)