DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5087 and Hectd1

DIOPT Version :9

Sequence 1:	NP_648279.1	Gene:	CG5087 / 39035	FlyBaseID:	FBgn0035953	Length:	1078	Species:	Drosophila melanogaster
Sequence 2:	XP_006240148.1	Gene:	Hectd1 / 362736	RGDID:	1561653	Length:	2610	Species:	Rattus norvegicus

Alignment Length:	776	Identity:	156/776 - (20%)
Similarity:	261/776 - (33%)	Gaps:	246/776 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   457 QQWRKLDSAEVVQVSRICGMYYAAL------NTLSQMKLDILTGICYSD--NVLYDIWLLITSLG 513
            :.|:...:.:.::.:|.|....||.      .|.|.:.....:.:..||  |:..:........|
  Rat  1927 RHWKLTGTNKSIRKNRNCSQLIAAYKDFCEHGTRSGLNQGASSSLQSSDILNLTKEQPQAKAGNG 1991

  Fly   514 PN-CGMKEYLELLKSETNLQKPQTAMLMLFCDCMTHYVTILDEHEMYTEQNPFKLNDYVLLTYFL 577
            .| ||:::.|:||:             :|:......|..|..|..  .||..|        |:..
  Rat  1992 QNPCGVEDVLQLLR-------------ILYIVASDPYSRISQEDG--DEQPQF--------TFPP 2033

  Fly   578 NNILYKLINDNLLAGAKNIVQHPVFLSLHTLMLCLYRRDCRRPFTPPKHWLIP-EVKPSTFINDL 641
            :....|.|...:|    ..::.|:.|:...|.....:...:.||      ||| |.:...|....
  Rat  2034 DEFTSKKITTKIL----QQIEEPLALASGALPDWCEQLTSKCPF------LIPFETRQLYFTCTA 2088

  Fly   642 EKAKRNAMLLLAKMPHIIPHEDRVKLFRKFVQNEKAVMGLTESACASPRSALIV--------IHR 698
            ..|.|..:.|..:....:.........|:....|..|..|.......||...::        ||.
  Rat  2089 FGASRAIVWLQNRREATVERTRTTSSVRRDDPGEFRVGRLKHERVKVPRGESLMEWAENVMQIHA 2153

  Fly   699 DRIVEDGYRQLAAQPTQALKGVIRVRFINQQGLHEAGIDQDGVFKEFLEETIKKVFDPSLNLFKT 763
            ||                 |.|:.|.|:.::|   .|:   |...||......:.....|..:..
  Rat  2154 DR-----------------KSVLEVEFLGEEG---TGL---GPTLEFYALVAAEFQRTDLGTWLC 2195

  Fly   764 TSD----------------------QR---LYPSPISYVQD-NHLE----LFEFVGRMLGKAVYE 798
            ..:                      ||   |:.:|  :.|| :.||    ||.|:|..|.|.:.:
  Rat  2196 DDNFPDDESRHVDLGGGLKPPGYYVQRSCGLFTAP--FPQDSDELERITKLFHFLGIFLAKCIQD 2258

  Fly   799 GIVVDVPFAS-FF-----------LSQLLGQTQ--QALYSCMDELPSLDNELYRSLT-------- 841
            ..:||:|.:. ||           :|:|:.:::  :.|:....:..:...|.:.||:
  Rat  2259 NRLVDLPISKPFFKLMCMGDIKSNMSKLIYESRGDRDLHCTESQSEASTEEGHDSLSVGSFEEDS 2323

  Fly   842 -----------------------------------FIKHYKQ----------------------- 848
                                               |:|..|.
  Rat  2324 KSEFILDPPKPKPPAWFNGILTWEDFELVNPHRARFLKEIKDLAIKRRQILGNKSLSEDEKNTKL 2388

  Fly   849 ---------------DVSDLNLTFSV--DQDVMGKIVTLALHPGGKARVVNDHNKLVYIHYMAFF 896
                           .:.||.|.|..  ...:.| ...:.|.|.|:..::...|...|:..|..|
  Rat  2389 QELVLKNPSGSGPPLSIEDLGLNFQFCPSSRIYG-FTAVDLKPSGEDEMITMDNAEEYVDLMFDF 2452

  Fly   897 HMNTQIREQTIAFNRGFRSIVNPEWLSLFSPPELQRLISGDTSPL----DLKDLQK----HTHYY 953
            .|:|.|::|..||..||..:...|.||.||..|:|.::.|:.||.    |:.:..:    :|...
  Rat  2453 CMHTGIQKQMEAFRDGFNKVFPMEKLSSFSHEEVQMILCGNQSPSWAAEDIINYTEPKLGYTRDS 2517

  Fly   954 GGFHDTHQVVCWLWDILAKDFTEEERKLFLKFVTSCSKPPLLGFAHLEPPFSIRCVEVSDDEDTG 1018
            .||....:|:|.:        :.:|||.||:|.|.||..|..|.|:|.|..::
  Rat  2518 PGFLRFVRVLCGM--------SSDERKAFLQFTTGCSTLPPGGLANLHPRLTV------------ 2562

  Fly  1019 DTIGSVIRGFFAIRKKDPLN-RLPTSSTCFNLLKLPNYQKKSTLRDKLRYAVSSNTGFELS 1078
                        :||.|..: ..|:.:||.:.||||.|..:..:|::| .|.:...||.|:
  Rat  2563 ------------VRKVDATDASYPSVNTCVHYLKLPEYSSEEIMRERL-LAATMEKGFHLN 2610

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5087	NP_648279.1	HECTc	694..1076	CDD:238033	107/525 (20%)
CG5087	NP_648279.1	HECTc	718..1075	CDD:214523	102/492 (21%)
Hectd1	XP_006240148.1	Ank_2	366..457	CDD:289560
		ANK repeat	366..393	CDD:293786
		ANK	369..479	CDD:238125
		ANK repeat	396..426	CDD:293786
		ANK repeat	428..457	CDD:293786
		F5_F8_type_C	1107..1240	CDD:304887
		MIB_HERC2	1277..1335	CDD:284184
		HECTc	2131..2608	CDD:238033	109/535 (20%)
		HECTc	2155..2607	CDD:214523	103/510 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900