DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5087 and Ufd4

DIOPT Version :9

Sequence 1:	NP_648279.1	Gene:	CG5087 / 39035	FlyBaseID:	FBgn0035953	Length:	1078	Species:	Drosophila melanogaster
Sequence 2:	NP_609369.1	Gene:	Ufd4 / 34378	FlyBaseID:	FBgn0032208	Length:	2727	Species:	Drosophila melanogaster

Alignment Length:	1040	Identity:	203/1040 - (19%)
Similarity:	357/1040 - (34%)	Gaps:	333/1040 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   238 ITLCLRPLIDGNFSRNLLAKFLSEILSVPALIYHLQQSVPQCLEQFSSMG----------LLKKA 292
            :|..::..:..||...|    ||...|.|:|..:..:::.......:|.|          |....
  Fly  1822 VTSLVKLALSSNFHSGL----LSTAQSYPSLSSNNSENIAPSNPSNTSAGQQSASTINHTLTMSL 1882

  Fly   293 LSISGDVQW--FEEFGTSMPGTKSLAFLGNIVNLFNI--DGQGESKELAYPLLTETTTSLLELIP 353
            .|.|.|.:.  .|:|   :...::.|.||::.:..::  |...|..|..|   .|...:||::
  Fly  1883 TSTSSDSEQVSLEDF---LESCRAPALLGDLDDEDDMDEDNDEEENEDEY---EEVGNTLLQV-- 1939

  Fly   354 NTVTTKGVFTQWHELLGWHTPGPEPAQNQNVALIKKQFHMLWDHR-CIKLLLGDLLK-------Q 410
              :.::.:.|...:         |..:|:.|.:.|::   .||.. .:|.....|:.       :
  Fly  1940 --MVSRNLLTFMDD---------EAMENRLVGVTKRK---SWDDEFVLKRQFSALIPAFDPRPGR 1990

  Fly   411 INLNYER--------IEFQSPQQ------------------PSISNLLRRALERSST-----RGV 444
            .|:|...        .|...|||                  |.|..:....::.|:|     |.|
  Fly  1991 TNVNQTSDLEISPLGAELPKPQQSGGPETIEQPLLGLKLRGPGIGGIPEVEIDLSNTDWTIFRAV 2055

  Fly   445 NLMGVASSKQSKQQWRK----------------------LDSAEVVQVSRICGMYYAA-LNTLSQ 486
            ..:...|......::||                      |:|.|..|...:.....|: |:..|.
  Fly  2056 QELLQCSQLNKLDKFRKIWEPTYTIVYREVSPEAQESTCLESEEFPQTPDVSSKSGASTLSPNSP 2120

  Fly   487 MKLDILTGICYSDNVLYDIWLLITSLGPNCGMKEYLELLKSETNLQKPQTAMLMLFCDCMTHYVT 551
            |.:    |...:||.|             |.:.:.||||.....|.:.:     :..|...|.|:
  Fly  2121 MHI----GFNVADNNL-------------CSVDDVLELLTQINGLNQSE-----IDSDVKEHGVS 2163

  Fly   552 ILDEHEMYTEQNPFKLNDYVLLTYFLNNILYKLINDNLLAGA-------KNIVQH-PVFLSLHTL 608
            :|.|.              :.::..:.|.|.:.|.|.|:..:       :|:.|. |......|.
  Fly  2164 VLSED--------------LFISKKITNKLQQQIQDPLVLASNALPNWCENLNQSCPFLFPFETR 2214

  Fly   609 ML--------------CLY-RRDC-----RRPFTPPK---HWLIPEVKPSTFINDLEKAKRNAML 650
            .|              ||. :||.     |.|...|:   |    |.:.....::..|..||..|
  Fly  2215 QLYFNCTSFGASRSIVCLQSQRDVTVERQRIPIMSPRRDDH----EFRIGRLKHERVKVPRNEDL 2275

  Fly   651 LLAKMPHIIPHEDRVKLFR-KFVQNEKAVMGLTES-----ACASPRSALIV-IHRDRIVEDGYRQ 708
            |:..|..:..|.:|..:.. :|:..|...:|.|..     |....||.|.: :..|.:.||
  Fly  2276 LMWAMQVMKTHCNRKSVLEVEFLDEEGTGLGPTLEFYALVAAEIQRSDLCMWLCDDDLGED---- 2336

  Fly   709 LAAQPTQALKGVIRV--RFINQQGLHEAGIDQDGVFKEFLEETIKKVFDPSLNLFKTTSDQRLYP 771
             ....||:.:|..:.  .::|::   |.||                                 :|
  Fly  2337 -TENSTQSAEGNSKPVGYYVNRR---EHGI---------------------------------FP 2364

  Fly   772 SPI---SYVQDNHLELFEFVGRMLGKAVYEGIVVDVPFASFFL-----SQLLGQTQQALYS---- 824
            :|:   |.:.:|.|:.|.|.|..:.|.:.:..:||:|.::.||     :::|.:..|.:.|
  Fly  2365 APLPQNSEICENVLKYFWFFGVFVAKVLQDMRLVDIPLSTSFLQLLCHNKVLSRNLQKVISDRRN 2429

  Fly   825 ---------------C-------------------MDELPSLDNELYRSLTFIKHY---KQDV-- 850
                           |                   ::.|..:|...|:.|..:::.   ||.:
  Fly  2430 GDLSVVSEDSDIVETCTKLLRTDSNKSNAFGGILSLENLKEIDPTRYQFLQEMQNLLLRKQSIEF 2494

  Fly   851 ----------------------------SDLNLTFSV--DQDVMGKIVTLALHPGGKARVVNDHN 885
                                        .||.|||:.  ...:.| .....|.|.|.:..|...|
  Fly  2495 DDTISAEKKHELINELKLQTQNGLEVSLEDLALTFTYLPSSSIYG-YTQAELLPNGSSVNVTIDN 2558

  Fly   886 KLVYIHYMAFFHMNTQIREQTIAFNRGFRSIVNPEWLSLFSPPELQRLISGDTSP-LDLKDLQKH 949
            ...|...:..|.:...|.:|..||:.||..:...:.|:.|:|.|.:.:|.|:..| ...:|:..:
  Fly  2559 LEAYCELLMNFILQDGIAQQMKAFSDGFNEVFPLKKLAAFTPSEARMMICGEQFPHWSREDIISY 2623

  Fly   950 THYYGGFHDTHQVVCWLWDILAKDFTEEERKLFLKFVTSCSKPPLLGFAHLEPPFSIRCVEVSDD 1014
            |....|::..........::|. ..:.:|||.||:|.|.||..|..|.|:|.|..::
  Fly  2624 TEPKLGYNKDSPGFQRFVNVLL-SMSGDERKAFLQFTTGCSSLPPGGLANLHPRLTV-------- 2679

  Fly  1015 EDTGDTIGSVIRGFFAIRKKDP-LNRLPTSSTCFNLLKLPNYQKKSTLRDKLRYAVSSNTGFELS 1078
                            :||.|. :...|:.:||.:.||||:|..:..::::|..| :...||.|:
  Fly  2680 ----------------VRKVDAGVGSYPSVNTCVHYLKLPDYPTEEIMKERLLTA-TKEKGFHLN 2727

Fly 1079 1078
Fly 2728 2727

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5087	NP_648279.1	HECTc	694..1076	CDD:238033	92/467 (20%)
CG5087	NP_648279.1	HECTc	718..1075	CDD:214523	86/441 (20%)
Ufd4	NP_609369.1	ANK repeat	393..420	CDD:293786
		ANK	396..509	CDD:238125
		ANK repeat	422..453	CDD:293786
		ANK repeat	455..484	CDD:293786
		F5_F8_type_C	1173..1298	CDD:329041
		MIB_HERC2	1333..1389	CDD:310955
		DamX	1576..>1725	CDD:330571
		HECTc	2265..2725	CDD:238033	108/527 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45447005
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.830