DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5087 and Su(dx)

DIOPT Version :9

Sequence 1:	NP_648279.1	Gene:	CG5087 / 39035	FlyBaseID:	FBgn0035953	Length:	1078	Species:	Drosophila melanogaster
Sequence 2:	NP_001259898.1	Gene:	Su(dx) / 33379	FlyBaseID:	FBgn0003557	Length:	949	Species:	Drosophila melanogaster

Alignment Length:	703	Identity:	174/703 - (24%)
Similarity:	272/703 - (38%)	Gaps:	168/703 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   443 GVNLMGVASSKQSKQQWRKLDSAEV-----VQVSRICGMYYAALNTLSQMKLDILTGICYSDNVL 502
            ||.| .|:.|...:.|.:..|...:     :::.:....||...||.|
  Fly   342 GVGL-PVSQSTDPQLQTQPADDEPLPAGWEIRLDQYGRRYYVDHNTRS----------------- 388

  Fly   503 YDIWLLITSLGPNCGMKE-------YLELLKSETNLQKPQTAMLMLFCDCM---THYVTILDEHE 557
             ..|...|.|.|...:::       |::....:|..|:|.:..||.|....   .|.|:..::..
  Fly   389 -TYWEKPTPLPPGWEIRKDGRGRVYYVDHNTRKTTWQRPNSERLMHFQHWQGQRAHVVSQGNQRY 452

  Fly   558 MYT--EQNPFKLNDYVL----------------------LTYFLNNILYK--------------- 583
            :|:  :|.|..:...|.                      ..||:|   :|
  Fly   453 LYSQQQQQPTAVTAQVTQDDEDALGPLPDGWEKKIQSDNRVYFVN---HKNRTTQWEDPRTQGQE 514

  Fly   584 --LINDNLL----------AGAKNIVQHPVFLSLHTLMLCLYRRDCRRPFTPPKHWLIPEVKPST 636
              |||:..|          ||.:..|.|                :.||               :|
  Fly   515 VSLINEGPLPPGWEIRYTAAGERFFVDH----------------NTRR---------------TT 548

  Fly   637 FINDLEKAKRNAMLLLAKMPHIIPHEDRVKL--FRKFVQNEKAVMGLTESACASPRSALIVIHRD 699
            |.:....|.:.|..:.. :|.......|.||  ||...|:.           |.|....|.:.|.
  Fly   549 FEDPRPGAPKGAKGVYG-VPRAYERSFRWKLSQFRYLCQSN-----------ALPSHIKITVTRQ 601

  Fly   700 RIVEDGYRQLAAQPTQALKGVIRVRFINQQGLHEAGIDQDGVFKEFLEETIKKVFDPSLNLFK-- 762
            .:.||.|.|:...|...|:..:.:.|..::||     |..||.:|:......:|.:|...||:
  Fly   602 TLFEDSYHQIMRLPAYELRRRLYIIFRGEEGL-----DYGGVSREWFFLLSHEVLNPMYCLFEYA 661

  Fly   763 TTSDQRLYPSPISYVQDNHLELFEFVGRMLGKAVYEGIVVDVPFASFFLSQLLGQTQQALYSCMD 827
            ..::..|..:|.|||..:||:.|:|:||.:..|:|.|..:...|...|..::|.:.     ..:.
  Fly   662 NKNNYSLQINPASYVNPDHLQYFKFIGRFIAMALYHGRFIYSGFTMPFYKRMLNKK-----LTIK 721

  Fly   828 ELPSLDNELYRSLTFIKHYKQDVSDLNLTFSVDQDVMGKIVTLALHPGGKARVVNDHNKLVYIHY 892
            ::.::|.|.|.||.::|....|...|.|.||||.:|:|:|:...|...|:...|.:.||..||..
  Fly   722 DIETIDPEFYNSLIWVKDNNIDECGLELWFSVDFEVLGQIIHHELKENGEKERVTEENKEEYITL 786

  Fly   893 MAFFHMNTQIREQTIAFNRGFRSIVNPEWLSLFSPPELQRLISGDTSPLDLKDLQKHTHYYGGFH 957
            |..:.|...|.:||..|..||..:|..|||..|...||:.::.| ...:|::|.|::|.|.....
  Fly   787 MTEWRMTRGIEQQTKTFLEGFNEVVPLEWLKYFDERELELILCG-MQDVDVEDWQRNTIYRHYNR 850

  Fly   958 DTHQVVCWLWDILAKDFTEEERKLFLKFVTSCSKPPLLGFAHLEPPFSIRCVEVSDDEDTGDTIG 1022
            ::.||| |.|..: ::...|:|...|:|||...:.|:.|||.|                    :|
  Fly   851 NSKQVV-WFWQFV-RETDNEKRARLLQFVTGTCRVPVGGFAEL--------------------MG 893

  Fly  1023 SVIRGFFAIRKKDPLNRLPTSSTCFNLLKLPNYQKKSTLRDKLRYAVSSNTGF 1075
            |.....|.|.|......||.|.||||.|.||.|:....|.:||.:|:....||
  Fly   894 SNGPQRFCIEKVGKETWLPRSHTCFNRLDLPPYKSYDQLVEKLTFAIEETEGF 946

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5087	NP_648279.1	HECTc	694..1076	CDD:238033	118/384 (31%)
CG5087	NP_648279.1	HECTc	718..1075	CDD:214523	108/358 (30%)
Su(dx)	NP_001259898.1	C2_E3_ubiquitin_ligase	48..173	CDD:175988
		WW	364..396	CDD:197736	6/49 (12%)
		WW	397..426	CDD:278809	5/28 (18%)
		WW	478..509	CDD:197736	4/33 (12%)
		WW	522..554	CDD:197736	9/62 (15%)
		HECTc	594..946	CDD:238033	116/384 (30%)
		HECTc	620..946	CDD:214523	108/358 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45447007
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.740