DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5087 and HUWE1

DIOPT Version :9

Sequence 1:	NP_648279.1	Gene:	CG5087 / 39035	FlyBaseID:	FBgn0035953	Length:	1078	Species:	Drosophila melanogaster
Sequence 2:	NP_001285288.1	Gene:	HUWE1 / 32510	FlyBaseID:	FBgn0030674	Length:	5151	Species:	Drosophila melanogaster

Alignment Length:	414	Identity:	125/414 - (30%)
Similarity:	198/414 - (47%)	Gaps:	45/414 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly   669 RKFVQNEKAVMGLTESACASPRSALIVIHRDRIVEDGYRQLAAQPTQALKGVIRVRFINQQGLHE 733
            ||:.|.|  :..|.|.......:  :.:.|..:.||.:|.|.....:..|....:.|.:::| .:
  Fly  4775 RKYFQTE--LERLDEGIRREEHT--VSVRRVTVFEDSFRVLYRLGPEEWKNRFYIVFEDEEG-QD 4834

  Fly   734 AGIDQDGVFKEFLEETIKKVFDPSLNLFKTTSDQRL--YPSPISYVQDNHLELFEFVGRMLGKAV 796
            ||    |:.:|:.....:::|:|...||..:...|:  ..:|.|:...|||..|:||||::.|||
  Fly  4835 AG----GLLREWYVIISREIFNPMYALFCVSPGDRVTYMINPSSHANPNHLSYFKFVGRVIAKAV 4895

  Fly   797 YEGIVVDVPFASFFLSQLLGQTQQALYSCMDELPSLDNELYRSLTFIKHYKQDVSDL--NLTFSV 859
            ::..:::..|...|...:||  :|..::.|:   |.|.|.|:.|.::  .|.|:|.|  .||||.
  Fly  4896 HDNKLLECYFTRSFYKHILG--KQVKHTDME---SQDYEFYKGLDYL--MKNDISTLGYELTFST 4953

  Fly   860 DQDVMGKIVTLALHPGGKARVVNDHNKLVYIHYMAFFHMNTQIREQTIAFNRGFRSIVNPEWLSL 924
            :....|......|.|.|:...|.:.||..|:..:....|:..||:|..||..||..|:....:|:
  Fly  4954 EVQEFGVTQIRDLKPNGRDTAVTEENKFEYVQLVCQLKMSGSIRQQLDAFLEGFYDIIPKHLISI 5018

  Fly   925 FSPPELQRLISGDTSPLDLKDLQKHTHYYGGFHDTHQVVCWLWDILAKDFTEEERKLFLKFVTSC 989
            |:..||:.|||| ...:|::||:.:|.|:.....:.|:. |.|..| :.|.:.:|..||:|||..
  Fly  5019 FNEQELELLISG-LPDIDIEDLKANTEYHKYTSKSAQIQ-WFWRAL-RSFDQADRAKFLQFVTGT 5080

  Fly   990 SKPPLLGFAHLEPPFSIRCVEVSDDEDTGDTIGSVIRGFFAIRKKDPLNRLPTSSTCFNLLKLPN 1054
            ||.||.||..||....|:..::..|:.:.|                   |||.:.||||.|.||.
  Fly  5081 SKVPLQGFGSLEGMNGIQKFQIHRDDRSTD-------------------RLPCAHTCFNQLDLPM 5126

  Fly  1055 YQKKSTLRDKLRYAV---SSNTGF 1075
            |:....||..|..|:   |...||
  Fly  5127 YKSYDKLRSCLLKAIHECSEGFGF 5150

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5087	NP_648279.1	HECTc	694..1076	CDD:238033	119/389 (31%)
CG5087	NP_648279.1	HECTc	718..1075	CDD:214523	112/363 (31%)
HUWE1	NP_001285288.1	DUF908	90..326	CDD:283630
		DUF913	621..989	CDD:283642
		UBA_like_SF	1467..1506	CDD:304366
		WWE	1756..1828	CDD:128922
		40S_SA_C	3575..3651	CDD:292740
		DUF4414	3675..3779	CDD:291075
		HECTc	4796..5149	CDD:238033	117/386 (30%)
		HECTc	4820..5148	CDD:214523	112/361 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45446987
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.740