DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5087 and smurf1

DIOPT Version :9

Sequence 1:	NP_648279.1	Gene:	CG5087 / 39035	FlyBaseID:	FBgn0035953	Length:	1078	Species:	Drosophila melanogaster
Sequence 2:	NP_001001943.1	Gene:	smurf1 / 321695	ZFINID:	ZDB-GENE-040426-2744	Length:	731	Species:	Danio rerio

Alignment Length:	417	Identity:	128/417 - (30%)
Similarity:	198/417 - (47%)	Gaps:	40/417 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly   665 VKLFRKFVQNEKAVMGLTESACASPRS--ALIVIHRDRIVEDGYRQLAAQPTQALKGVIRVRFIN 727
            |:..|..||..|.:.  .|.:...|::  ..|.:.|:.|.|:.|||:.....:.||..:.|:|..
Zfish   346 VRYERDLVQKLKVLR--HELSLQQPQAGHCRIEVSREEIFEESYRQIMKMRPKDLKKRLMVKFRG 408

  Fly   728 QQGLHEAGIDQDGVFKEFLEETIKKVFDPSLNLFKTTSDQ--RLYPSPISYVQDNHLELFEFVGR 790
            ::||     |..||.:|:|.....::.:|...||:.::|.  .|..:|.|.:..:||..|.||||
Zfish   409 EEGL-----DYGGVAREWLYLLCHEMLNPYYGLFQYSTDNIYTLQINPDSSINPDHLSYFHFVGR 468

  Fly   791 MLGKAVYEGIVVDVPFASFFLSQLLGQTQQALYSCMDELPSLDNELYRSLTFIKHYKQDV-SDLN 854
            ::|.||:.|..::..|...|..||||:..|     :.:|.::|.||::||.:|  .:.|: |.|:
Zfish   469 IMGLAVFHGHYINGGFTLPFYKQLLGKPIQ-----LCDLETVDPELHKSLVWI--LENDITSVLD 526

  Fly   855 LTFSVDQDVMGKIVTLALHPGGKARVVNDHNKLVYIHYMAFFHMNTQIREQTIAFNRGFRSIVNP 919
            .||.|:.:..||.:...|.|.||...|.:.||..|:.....:.....|..|.:|..:||..::..
Zfish   527 HTFCVEHNAFGKFLQHELKPNGKNIPVTEENKKEYVRLYVNWRFMRGIEAQFLALQKGFNELIPQ 591

  Fly   920 EWLSLFSPPELQRLISGDTSPLDLKDLQKHTHYYGGFHDTHQVVCWLWDILAKDFTEEERKLFLK 984
            ..|..|...||: ||.|....:||.|.:.:|.......|:: :|.|.|..: :.|.||.|...|:
Zfish   592 HLLKPFDNKELE-LIIGGLGKIDLNDWKANTRLKHCVADSN-IVKWFWQAV-ESFDEERRGRLLQ 653

  Fly   985 FVTSCSKPPLLGFAHLEPPFSIRCVEVSDDEDTGDTIGSVIRGFFAIRKKDP-LNRLPTSSTCFN 1048
            |||..::.||.||..|:                |.| ||.....|.|...|. .:.||.:.||||
Zfish   654 FVTGSTRVPLQGFKALQ----------------GST-GSAGPRLFTIHLIDANTDNLPKAHTCFN 701

  Fly  1049 LLKLPNYQKKSTLRDKLRYAVSSNTGF 1075
            .:.:|.|:....|.:||..||....||
Zfish   702 RIDIPPYESYEKLYEKLLTAVEETCGF 728

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5087	NP_648279.1	HECTc	694..1076	CDD:238033	121/386 (31%)
CG5087	NP_648279.1	HECTc	718..1075	CDD:214523	111/360 (31%)
smurf1	NP_001001943.1	C2_Smurf-like	14..138	CDD:176028
		WW	234..266	CDD:197736
		WW	280..312	CDD:197736
		HECTc	373..728	CDD:238033	119/386 (31%)
		HECTc	397..728	CDD:214523	112/362 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810