DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5087 and Trip12

DIOPT Version :9

Sequence 1:	NP_648279.1	Gene:	CG5087 / 39035	FlyBaseID:	FBgn0035953	Length:	1078	Species:	Drosophila melanogaster
Sequence 2:	XP_038939619.1	Gene:	Trip12 / 316575	RGDID:	1306607	Length:	2074	Species:	Rattus norvegicus

Alignment Length:	1141	Identity:	238/1141 - (20%)
Similarity:	386/1141 - (33%)	Gaps:	373/1141 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    73 VASNVYPVLRRYLTQIRLDKSDVRARERLERICRYIIKAMESENTKLSYAALCLFKERSL----- 132
            :....:..:.||.:...:|.|: .|...|:|:|    .|.|..|.::...|.||.:.||:
  Rat  1172 IKEQAHKFVERYFSSENMDGSN-PALNVLQRLC----AATEQLNLQVDGGAECLVEIRSIVSESD 1231

  Fly   133 ---------PWIAHIKILLTNCLTLLPELKPENHADSLSLAL--FLHTLVVFTAPKSWAILRNAQ 186
                     .::..:.:.||:        |.|..|.|..:.|  |||  |.|::|    :.....
  Rat  1232 VSSFEIQHSGFVKQLLLYLTS--------KSEKDAVSREIRLKRFLH--VFFSSP----LPGEEP 1282

  Fly   187 FEKLQPAMQKICCNIQGHLVQHDFYKIMRLVLIRGTVREELSVKPVTLVAIITLCLRPLIDGN-- 249
            ..:::|.         ||.      .::.||........::...||.        :.....||
  Rat  1283 VGRVEPV---------GHA------PLLALVHKMNNCLSQMEQFPVK--------VHDFPSGNGS 1324

  Fly   250 ---FSRNLLAKFLSEILSVPALIYHLQQSVPQC------------LEQFSSMGLLKKALSISG-- 297
               ||.|..::.| :..:...|...||:. |.|            ::..:.:..:::.|.:.|
  Rat  1325 GGSFSLNRGSQAL-KFFNTHQLKCQLQRH-PDCANVKQWKGGPVKIDPLALVQAIERYLVVRGIF 1387

  Fly   298 -------DVQWFEEFGTSMPGTKSLA--FL--GNI----------------------VNLFNIDG 329
                   |.:..::.|:.....:|||  ||  ||:                      |..|::..
  Rat  1388 RYGRVREDDEDSDDDGSDEEIDESLAAQFLNSGNVRHRLQFYIGEHLLPYNMTVYQAVRQFSVQA 1452

  Fly   330 QGESKELAYPLLTETTTSLLELIPNTVTTKGVFTQWHELLGWHTPGPEPAQNQ-----------N 383
            :.|.:.      |:..:       |.:...|::|:.|.:  |:.|..|..::.           .
  Rat  1453 EDERES------TDDES-------NPLGRAGIWTKTHTI--WYKPVREDEESSKDCVGGKRGRAQ 1502

  Fly   384 VALIK------KQFHMLW-DHRCIKLLLGDLLKQINLNYERIEFQSPQQPSISNLLRRALERSST 441
            .|..|      |:...|| |..|..:.....:..|....|.|.|:.|....|  ||.|.|...|
  Rat  1503 TAPTKTSPRNAKKHDELWHDGVCPSVANPLEVYLIPTPPENITFEDPSLDVI--LLLRVLHAIS- 1564

  Fly   442 RGVNLMGVASSKQSKQQWRKL-DSA---EVVQVSR-ICGMYYAALNTLSQMKLDILTGICYSDNV 501
                           :.|..| |:|   |::..|. |.....|..|...|..|.|:||     |:
  Rat  1565 ---------------RYWYYLYDNAMCKEIIPTSEFINSKLTAKANRQLQDPLVIMTG-----NI 1609

  Fly   502 LYDIWLLITSLGPNCGMKEYLELLKSETNLQKPQTAMLMLFCDCMTHYVTILDEHEMYTEQNPFK 566
              ..||  |.||..|             ....|.....|||      |||..|.
  Rat  1610 --PTWL--TELGKTC-------------PFFFPFDTRQMLF------YVTAFDR----------- 1640

  Fly   567 LNDYVLLTYFLNNILYKLINDNLLAGAKNIVQHPVFLSLHTLMLCLYRRDCRRPFTPPKHWLIPE 631
                       :..:.:|::.|                                         ||
  Rat  1641 -----------DRAMQRLLDTN-----------------------------------------PE 1653

  Fly   632 VKPSTFINDLEKAKRNAMLLLAKMPHIIPHEDRVKLFRKFVQNEKAVMGLTESACASPRS--ALI 694
            :..|    |.:.::            :.|..||    :|...|.:.::...||......|  |::
  Rat  1654 INQS----DSQDSR------------VAPRLDR----KKRTVNREELLKQAESVMQDLGSSRAML 1698

  Fly   695 VIHRDRIVEDG-------YRQLAAQPTQALKGVIR---VRFINQQGLHEAGIDQDGVFKEFLEET 749
            .|..:..|..|       |..::.:..:|..|:.|   |...|.:|      .|:|.
  Rat  1699 EIQYENEVGTGLGPTLEFYALVSQELQRADLGLWRGEEVTLSNPKG------SQEGT-------- 1749

  Fly   750 IKKVFDPSLNLFKTTSDQRLYPSPISYVQDNHLELFEFVGRMLGKAVYEGIVVDVPFASFFLSQL 814
              |.......||.....:...|:.|:.|:..    |.|:|:::.||:.:..:||:|....|...:
  Rat  1750 --KYIQNLQGLFALPFGRTAKPAHIAKVKMK----FRFLGKLMAKAIMDFRLVDLPLGLPFYKWM 1808

  Fly   815 LGQ-TQQALYSCMDELPSLDNELYRSLTFI---KHYKQD---------------------VSDLN 854
            |.| |....:...|..|.:...:|.....:   |..:||                     |.||.
  Rat  1809 LRQETSLTSHDLFDIDPVVARSVYHLEDIVRQKKRLEQDKSQTKESLQYALETLTMNGCSVEDLG 1873

  Fly   855 LTFSVDQDVMGKIVTLALHPGGKARVVNDHNKLVYIHYMAFFHMNTQIREQTIAFNRGFRSIVNP 919
            |.|:     :.....:.|..|||...|..||...|:..:.|:.:|..:..|..:|..||.|:...
  Rat  1874 LDFT-----LPGFPNIELKKGGKDIPVTIHNLEEYLRLVIFWALNEGVCRQFDSFRDGFESVFPL 1933

  Fly   920 EWLSLFSPPELQRLISGDTSPL-DLKDLQKHTHYYGGFHDTHQVVCWLWDILAKDFTEEERKLFL 983
            ..|..|.|.||.:|:.|..:.. |.|.|.:......|:....:.|.:|::||: .|..|:::|||
  Rat  1934 SHLQYFYPEELDQLLCGSKADTWDAKTLMECCRPDHGYTHDSRAVKFLFEILS-SFDNEQQRLFL 1997

  Fly   984 KFVTSCSKPPLLGFAHLEPPFSIRCVEVSDDEDTGDTIGSVIRGFFAIRK-----KDPLNRLPTS 1043
            :|||...:.|:.||..|.||.:|                        :||     ::|.:.||:.
  Rat  1998 QFVTGSPRLPVGGFRSLNPPLTI------------------------VRKTFESTENPDDFLPSV 2038

  Fly  1044 STCFNLLKLPNYQKKSTLRDKLRYAV-SSNTGFELS 1078
            .||.|.||||:|.....:||||..|. .....|.||
  Rat  2039 MTCVNYLKLPDYSSIEIMRDKLLIAAREGQQSFHLS 2074

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5087	NP_648279.1	HECTc	694..1076	CDD:238033	104/423 (25%)
CG5087	NP_648279.1	HECTc	718..1075	CDD:214523	99/391 (25%)
Trip12	XP_038939619.1	SRP1	489..>714	CDD:227396
		WWE	814..876	CDD:397111
		HECTc	1672..2072	CDD:238033	110/449 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900