DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5087 and Hecw2

DIOPT Version :9

Sequence 1:	NP_648279.1	Gene:	CG5087 / 39035	FlyBaseID:	FBgn0035953	Length:	1078	Species:	Drosophila melanogaster
Sequence 2:	NP_001101688.1	Gene:	Hecw2 / 316395	RGDID:	1593244	Length:	1578	Species:	Rattus norvegicus

Alignment Length:	945	Identity:	220/945 - (23%)
Similarity:	355/945 - (37%)	Gaps:	253/945 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   174 TAPKSWAILRNA----QFEKLQPAMQKI------------CCNIQGHLVQHDFYKI-----MRLV 217
            |||.:..:|:.:    |.|:|....|.|            ...|.|...:.||::.     ...|
  Rat   845 TAPPAPQVLQRSNSIQQMEQLNRRYQSIRRTMTNERPEENTSAIDGAGEEADFHQASADFRRENV 909

  Fly   218 LIRGTVREELSVKPVTLVAIITLCLR-PLIDGNFSRNLLAKFLSEILSVPALIYHLQQSVPQCLE 281
            |...|.|..|           ||.|: |.:          |||     :....:.:..|.|....
  Rat   910 LPHSTSRSRL-----------TLLLQSPPV----------KFL-----ISPEFFTVLHSNPSAYR 948

  Fly   282 QFSSMGLLKKALS-ISGDVQWFEEFGTSMPGTKSLAFLGNIVNLFNIDGQGESKELAYPLLTETT 345
            .|::...||..:: :..|...||.:..:..       |...:|:|      .:|:|..|
  Rat   949 MFTNNTCLKHMITKVRRDTHHFERYQHNRD-------LVGFLNMF------ANKQLELP------ 994

  Fly   346 TSLLELIPNTVTTKGVFTQWHELLGWHTPGPEPAQNQNVALIKKQFHMLWDHRCIKLLLGDLLKQ 410
                                   .||                    .|..||:.....
  Rat   995 -----------------------RGW--------------------EMKHDHQGKAFF------- 1009

  Fly   411 INLNYERIEFQSPQQPSISNLLRRALERSSTRGVNLMGVASSKQSKQQWRKLDSAEVVQVSRICG 475
            ::.|.....|..|:.|..|:....||..              :|...:.|...:.||.:.||..|
  Rat  1010 VDHNSRTTTFIDPRLPLQSSRPTSALVH--------------RQHLTRQRSHSAGEVGEDSRHAG 1060

  Fly   476 -----MYYAALNTLSQMKLDILTGICYSD---------NVLYDIWLLITSLGPNCGMKEYLELLK 526
                 ...:..||:|:.:...:..:.|:|         |:|..:......|..|..::|.::.::
  Rat  1061 PPVLPRPASTFNTVSRPQYQDMVPVAYNDKIVAFLRQPNILEILQERQPDLARNHSLREKIQFIR 1125

  Fly   527 SETNLQKPQTAMLMLFCDCMTHYVTILDEHEMYTEQNPFKLNDYVLLTYFLNNILYKLINDNLLA 591
            :|..   |....|....|.:                        :||:.|...|:..:....||
  Rat  1126 TEGT---PGLVRLSSDADLV------------------------MLLSLFEEEIMSYVPPHALL- 1162

  Fly   592 GAKNIVQHPVFLSLHTLMLCLYRRDCRRPFTPPKHWLIPEVKPSTFINDLEKAKRNAMLLLAKMP 656
                   ||.:              |:.|...|..  .|:..|.|       .:.||.   |..|
  Rat  1163 -------HPSY--------------CQSPRGSPVS--SPQNSPGT-------QRANAR---APAP 1194

  Fly   657 HIIPHEDRVKLFRKFVQNEKAVMGLTESACASPRSALIVIHRDRIVEDGYRQLAAQPTQAL-KGV 720
            :....|.:::.|.:.::        |:.....|....::|.||.::||.:.|:.....:.| :..
  Rat  1195 YKRDFEAKLRNFYRKLE--------TKGYGQGPGKLKLIIRRDHLLEDAFNQIMGYSRKDLQRNK 1251

  Fly   721 IRVRFINQQGLHEAGIDQDGVFKEFLEETIKKVFDPSLNLFKTTSDQ--RLYPSPISYVQDNHLE 783
            :.|.|:.::||     |..|..:||.....:::|:|...||:.:::.  .:..||:|...|||.|
  Rat  1252 LYVTFVGEEGL-----DYSGPSREFFFLVSRELFNPYYGLFEYSANDTYTVQISPMSAFVDNHHE 1311

  Fly   784 LFEFVGRMLGKAVYEGIVVDVPFASFFLSQLLGQTQQALYSCMDELPSLDNELYRSLTFIKHYKQ 848
            .|.|.||:||.|:....::|..|...|...||     .:...:.:|..||.|.::||.::|  ..
  Rat  1312 WFRFSGRILGLALIHQYLLDAFFTRPFYKALL-----RILCDLSDLEYLDEEFHQSLQWMK--DN 1369

  Fly   849 DVSD-LNLTFSVDQDVMGKIVTLALHPGGKARVVNDHNKLVYIHYMAFFHMNTQIREQTIAFNRG 912
            |:.| |:|||:|:::|.|:|....|.|||....|.:.||..||..|..:.:...:.:||.:..||
  Rat  1370 DIHDILDLTFTVNEEVFGQITERELKPGGANIPVTEKNKKEYIERMVKWRIERGVVQQTESLVRG 1434

  Fly   913 FRSIVNPEWLSLFSPPELQRLISGDTSPLDLKDLQKHTHYYGGFHDTHQVVCWLWDILAKDFTEE 977
            |..:|:...:|:|...||:.:|:| |:.:||.|.:.:|.|.||:||.|.|:.|.|..:.: |..|
  Rat  1435 FYEVVDARLVSVFDARELELVIAG-TAEIDLNDWRNNTEYRGGYHDNHIVIRWFWAAVER-FNNE 1497

  Fly   978 ERKLFLKFVTSCSKPPLLGFAHLEPPFSIRCVEVSDDEDTGDTIGSVIRGFFAIRKKDPLNRLPT 1042
            :|...|:|||..|..|..|||.|.                    ||.....|.:.|...:..||.
  Rat  1498 QRLRLLQFVTGTSSIPYEGFASLR--------------------GSNGPRRFCVEKWGKITALPR 1542

  Fly  1043 SSTCFNLLKLPNYQKKSTLRDKLRYAVSSNTGFEL 1077
            :.||||.|.||.|...|.|.:||..||...:.|.|
  Rat  1543 AHTCFNRLDLPPYPSFSMLYEKLLTAVEETSTFGL 1577

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5087	NP_648279.1	HECTc	694..1076	CDD:238033	124/385 (32%)
CG5087	NP_648279.1	HECTc	718..1075	CDD:214523	117/359 (33%)
Hecw2	NP_001101688.1	HECW_N	45..162	CDD:406866
		C2_NEDL1-like	185..321	CDD:176073
		MDN1	<396..741	CDD:227596
		NESP55	<464..632	CDD:115071
		WW	815..844	CDD:395320
		HECW1_helix	921..987	CDD:408233	17/93 (18%)
		WW	993..1024	CDD:197736	9/86 (10%)
		HECTc	1222..1576	CDD:238033	124/387 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810