Protein Alignment CG5087 and Hectd3

DIOPT Version :10

• Sequence 1: NP_648279.1
• Gene: CG5087 / 39035
• FlyBaseID: FBgn0035953
• Length: 1078
• Species: Drosophila melanogaster
• Sequence 2: NP_001386141.1
• Gene: Hectd3 / 313525
• RGDID: 1309823
• Length: 861
• Species: Rattus norvegicus
• Alignment Length: 786
• Identity: 161/786 - (20%)
• Similarity: 299/786 - (38%)
• Gaps: 198/786 - (25%)

  Fly   364 QWHELLGW---HTPG--PEPAQNQNVALIKKQFHM--LWDHRCIKLLLGDLLKQINLNYERIEFQ 421
            :|.:::..   |..|  |:||:....| :::..::  .|.:.|.:    ||   |:..|:.:..:
  Rat   177 RWEQVVDLTYSHRLGSRPQPAEAYTEA-VQRLLYVPPTWTYECDE----DL---IHFLYDHLGKE 233

  Fly   422 SPQQPSISNLLRRALERSSTRGVNLMGVASSKQSK---------QQWRKLDSAEVVQVSRIC--- 474
            .....|:...:......|.|...|:..:..|....         |.|.:|...:...|.::.
  Rat   234 DENLGSVKQYVESIDVSSYTEEFNVSCLTDSNADTYWESDGSQCQHWVRLTMKKGTIVKKLLLTV 298

  Fly   475 -----------GMYYAA----LNTLSQMKLD--ILTGICYSDNVLYDIWLLITSLGPNC---GMK 519
                       .:.|..    |..||.:.:|  ::..:|..:::...:.::...: ..|   |:.
  Rat   299 DTTDDNFMPKRVVVYGGEGDNLKKLSDVNIDETLIGDVCVLEDMTVHLPVIEIRI-VECRDDGID 362

  Fly   520 EYLELLKSETNLQKPQTAMLMLFCDC-MTHYVTI--LDEHEMYTEQNPFKLNDYVLLTYF---LN 578
            ..|..:|.:::.|:.......||... :..|..:  .|...:|...        |||..|   |:
  Rat   363 VRLRGVKIKSSRQRELGLNADLFQPASLVRYPRLEGTDPEVLYRRA--------VLLQRFIKILD 419

  Fly   579 NILYKLIN--DNLLAGAKNIVQHPVFLSLHTLMLCLYRRDCRRPFTPPKHWLIPEVKPSTF---I 638
            ::|:.|:.  |:.|.....|.|...||                        |:...:||..   :
  Rat   420 SVLHHLVPAWDHTLGTFSEIKQVKQFL------------------------LLSRQRPSLVTQCL 460

  Fly   639 NDLEKAKRNAMLLLAKMPHIIPHEDRVKLFRKFVQNEKAVMGLTESACASPRSALIVIHRDRIVE 703
            .|.|.:|          |..:|   |:.:.|:        :.:...||.|...|.    ::.:..
  Rat   461 RDSESSK----------PSFMP---RLYINRR--------LAMEHRACPSRDPAC----KNAVFT 500

  Fly   704 DGYRQLAAQPTQALKGVIRVRFINQ-------QGLHEAGIDQDGVFKEFLEETIKKVFDPS---- 757
            ..|..|  :|:...:..:..|:..:       :.:.|..|||.|.|::.|.:..:::...|
  Rat   501 QVYEGL--KPSDKYEKPLDYRWPMRYDQWWECKFIAEGIIDQGGGFRDSLADMSEELCPSSADTP 563

  Fly   758 --LNLFKTTSDQ--------RLY-PSPISYVQDNHLELFEFVGRMLGKAV--YEGIVVDVPFASF 809
              |..|..|::|        .:| |:|    .......:|::|:::|.|:  .|.:|:.:|  .|
  Rat   564 VPLPFFVRTANQGNGTGEARDMYVPNP----SCRDFAKYEWIGQLMGAALRGKEFLVLALP--GF 622

  Fly   810 FLSQLLGQTQQALYSCMDELPSLDNELYRSLTFIKHYKQDVSDL----NLTFSV---DQDVMGKI 867
            ...||.|:.    .|...:.|::|:.|.:.|..::...::..:.    .|||:.   ||.|
  Rat   623 VWKQLSGEE----VSWSKDFPAVDSVLVKLLEVMEGVDKETFEFKFGKELTFTTVLSDQQV---- 679

  Fly   868 VTLALHPGGKARVVNDHNKLVYIHYMAFFHMNTQIREQTIAFNRGFRSIVNPEWLSLFSPPELQR 932
              :.|.|||...||...::|.:|..:....:. :.:||..|...|...:|....|.|.:..||::
  Rat   680 --VELIPGGTGIVVGYEDRLRFIQLVQKARLE-ESKEQVAAMQAGLLKVVPQAVLDLLTWQELEK 741

  Fly   933 LISGDTSPLDLKDLQKHTHYYGGFHDTHQVVCWLWDILAKDFTEEERKLFLKFVTSCSKPPLLGF 997
            .:.||.. :.:..|:|.|. :..|..:...|.:.|:.| .:||.|:|..||:|||..|:.|  ..
  Rat   742 KVCGDPE-VTVDALRKLTR-FEDFEPSDTRVQYFWEAL-NNFTNEDRSRFLRFVTGRSRLP--AR 801

  Fly   998 AHLEPPFSIRCVEVSDDEDTGDTIGSVIRGFFAIRKKDPLNRLPTSSTCFNLLKLPNYQKKSTLR 1062
            .::.|                |.:|           .:..:.||.||||.:.|.||:|.......
  Rat   802 IYIYP----------------DKLG-----------YETTDALPESSTCSSTLFLPHYASAKVCE 839

  Fly  1063 DKLRYA 1068
            :|||||
  Rat   840 EKLRYA 845

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG5087	NP_648279.1	IQCD	20..50	CDD:467745
		HECTc	694..1076	CDD:238033	96/406 (24%)
Hectd3	NP_001386141.1	APC10-HECTD3	238..371	CDD:176487	19/133 (14%)
		HECT	579..845	CDD:459880	78/314 (25%)