DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5087 and Smurf2

DIOPT Version :9

Sequence 1:	NP_648279.1	Gene:	CG5087 / 39035	FlyBaseID:	FBgn0035953	Length:	1078	Species:	Drosophila melanogaster
Sequence 2:	NP_001100531.1	Gene:	Smurf2 / 303614	RGDID:	1310067	Length:	748	Species:	Rattus norvegicus

Alignment Length:	838	Identity:	186/838 - (22%)
Similarity:	313/838 - (37%)	Gaps:	222/838 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   327 IDGQGESKELAYPLLTETTTSLLELIPNTVTTKGVFTQWHEL-LGWHTPGPEPAQNQNVALIKKQ 390
            :||.|:...      |:|       :.||:..|  :.|.::| :|         ::.:|.:
  Rat    41 VDGSGQCHS------TDT-------VKNTLDPK--WNQHYDLYIG---------KSDSVTI---- 77

  Fly   391 FHMLWDHR------------CIKLLLGDLLKQINLNYERIEF--QSPQQPSISNLLRRALERSST 441
              .:|:|:            |::||...:.:..:..|:|::.  ..|.            :..:.
  Rat    78 --SVWNHKKIHKKQGAGFLGCVRLLSNAINRLKDTGYQRLDLCKLGPN------------DNDTV 128

  Fly   442 RGVNLMGVASSKQSKQQWRKLDSAEVVQVSRICG-----------------MYYAALNTLSQMKL 489
            ||    .:..|.||:.  |.....:||..||:..                 .|...:...:|.:.
  Rat   129 RG----QIVVSLQSRD--RIGTGGQVVDCSRLFDNDLPDGWEERRTASGRIQYLNHITRTTQWER 187

  Fly   490 DILTGICYSD-----NVLYDIWLLITSL-GPNCGMKEYLELLKSETNLQKPQTAMLMLFCDCMTH 548
            .......||.     :...|....||.. |..||......|.:.....|:.:..|      ..||
  Rat   188 PTRPASEYSSPGRPLSCFVDENTPITGTNGATCGQSSDPRLAERRVRSQRHRNYM------SRTH 246

  Fly   549 YVTILDEHEMYTEQNPFKLNDYVLLTYF-------------LNNILYKLIND--------NLLAG 592
            ..|..|..|.|.::...:...|.|.|..             |:||..:.:..        |...|
  Rat   247 LHTPPDLPEGYEQRTTQQGQVYFLHTQTGVSTWHDPRVPRDLSNINCEELGPLPPGWEIRNTATG 311

  Fly   593 AKNIVQH----------PVFLSLHTLM----------------LCLYRRDCRRPFTPPKHWLIPE 631
            ....|.|          .:..:||.::                ||....:|   .|.|::
  Rat   312 RVYFVDHNNRTTQFTDPRLSANLHLVLNRQNQLKDQQQQQVVSLCPDDTEC---LTVPRY----- 368

  Fly   632 VKPSTFINDLEKAKRNAMLLLAKMPHIIPHEDRVKLFRKFVQNEKAVMGLTESACASPRSALIVI 696
                         ||:.:             .::|:.|:.:..::...|          ...|.:
  Rat   369 -------------KRDLV-------------QKLKILRQELSQQQPQAG----------HCRIEV 397

  Fly   697 HRDRIVEDGYRQLAAQPTQALKGVIRVRFINQQGLHEAGIDQDGVFKEFLEETIKKVFDPSLNLF 761
            .|:.|.|:.|||:.....:.|...:.::|..::||     |..||.:|:|.....::.:|...||
  Rat   398 SREEIFEESYRQVMKMRPKDLWKRLMIKFRGEEGL-----DYGGVAREWLYLLSHEMLNPYYGLF 457

  Fly   762 KTTSDQ--RLYPSPISYVQDNHLELFEFVGRMLGKAVYEGIVVDVPFASFFLSQLLGQTQQALYS 824
            :.:.|.  .|..:|.|.|...||..|.||||::|.||:.|..:|..|...|..||||::     .
  Rat   458 QYSRDDIYTLQINPDSAVNPEHLSYFHFVGRIMGMAVFHGHYIDGGFTLPFYKQLLGKS-----I 517

  Fly   825 CMDELPSLDNELYRSLTFIKHYKQDVSD-LNLTFSVDQDVMGKIVTLALHPGGKARVVNDHNKLV 888
            .:|::..:|.:|:.||.:|  .:.|::. |:.||.|:.:..|:|:...|.|.||:..|.:.||..
  Rat   518 TLDDMELVDPDLHNSLVWI--LENDITGVLDHTFCVEHNAYGEIIQHELKPNGKSIPVTEENKKE 580

  Fly   889 YIHYMAFFHMNTQIREQTIAFNRGFRSIVNPEWLSLFSPPELQRLISGDTSPLDLKDLQKHTHYY 953
            |:.....:.....|..|.:|..:||..::....|..|...||:.:|.| ...:|:.|.:.:|...
  Rat   581 YVRLYVNWRFLRGIEAQFLALQKGFNEVIPQHLLKTFDEKELELIICG-LGKIDVSDWKANTRLK 644

  Fly   954 GGFHDTHQVVCWLWDILAKDFTEEERKLFLKFVTSCSKPPLLGFAHLEPPFSIRCVEVSDDEDTG 1018
            ....|:: ||.|.|..: :.|.||.|...|:|||..|:.||.||..|:
  Rat   645 HCTPDSN-VVKWFWKAV-ELFDEERRARLLQFVTGSSRVPLQGFKALQ----------------- 690

  Fly  1019 DTIGSVIRGFFAIRKKDP-LNRLPTSSTCFNLLKLPNYQKKSTLRDKLRYAVSSNTGF 1075
               |:.....|.|.:.|. .|.||.:.||||.:.:|.|:....|.:||..|:....||
  Rat   691 ---GAAGPRLFTIHQIDACTNNLPKAHTCFNRIDIPPYESYEKLYEKLLTAIEETCGF 745

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5087	NP_648279.1	HECTc	694..1076	CDD:238033	115/386 (30%)
CG5087	NP_648279.1	HECTc	718..1075	CDD:214523	105/360 (29%)
Smurf2	NP_001100531.1	C2_Smurf-like	13..137	CDD:176028	23/141 (16%)
		PRP40	155..>236	CDD:227435	11/80 (14%)
		WW	159..188	CDD:395320	2/28 (7%)
		WW	252..283	CDD:197736	6/30 (20%)
		WW	298..330	CDD:197736	4/31 (13%)
		HECTc	393..745	CDD:238033	113/386 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910