Protein Alignment CG5087 and Smurf2

DIOPT Version :10

• Sequence 1: NP_648279.1
• Gene: CG5087 / 39035
• FlyBaseID: FBgn0035953
• Length: 1078
• Species: Drosophila melanogaster
• Sequence 2: NP_001100531.1
• Gene: Smurf2 / 303614
• RGDID: 1310067
• Length: 748
• Species: Rattus norvegicus
• Alignment Length: 838
• Identity: 186/838 - (22%)
• Similarity: 313/838 - (37%)
• Gaps: 222/838 - (26%)

  Fly   327 IDGQGESKELAYPLLTETTTSLLELIPNTVTTKGVFTQWHEL-LGWHTPGPEPAQNQNVALIKKQ 390
            :||.|:...      |:|       :.||:..|  :.|.::| :|         ::.:|.:
  Rat    41 VDGSGQCHS------TDT-------VKNTLDPK--WNQHYDLYIG---------KSDSVTI---- 77

  Fly   391 FHMLWDHR------------CIKLLLGDLLKQINLNYERIEF--QSPQQPSISNLLRRALERSST 441
              .:|:|:            |::||...:.:..:..|:|::.  ..|.            :..:.
  Rat    78 --SVWNHKKIHKKQGAGFLGCVRLLSNAINRLKDTGYQRLDLCKLGPN------------DNDTV 128

  Fly   442 RGVNLMGVASSKQSKQQWRKLDSAEVVQVSRICG-----------------MYYAALNTLSQMKL 489
            ||    .:..|.||:.  |.....:||..||:..                 .|...:...:|.:.
  Rat   129 RG----QIVVSLQSRD--RIGTGGQVVDCSRLFDNDLPDGWEERRTASGRIQYLNHITRTTQWER 187

  Fly   490 DILTGICYSD-----NVLYDIWLLITSL-GPNCGMKEYLELLKSETNLQKPQTAMLMLFCDCMTH 548
            .......||.     :...|....||.. |..||......|.:.....|:.:..|      ..||
  Rat   188 PTRPASEYSSPGRPLSCFVDENTPITGTNGATCGQSSDPRLAERRVRSQRHRNYM------SRTH 246

  Fly   549 YVTILDEHEMYTEQNPFKLNDYVLLTYF-------------LNNILYKLIND--------NLLAG 592
            ..|..|..|.|.::...:...|.|.|..             |:||..:.:..        |...|
  Rat   247 LHTPPDLPEGYEQRTTQQGQVYFLHTQTGVSTWHDPRVPRDLSNINCEELGPLPPGWEIRNTATG 311

  Fly   593 AKNIVQH----------PVFLSLHTLM----------------LCLYRRDCRRPFTPPKHWLIPE 631
            ....|.|          .:..:||.::                ||....:|   .|.|::
  Rat   312 RVYFVDHNNRTTQFTDPRLSANLHLVLNRQNQLKDQQQQQVVSLCPDDTEC---LTVPRY----- 368

  Fly   632 VKPSTFINDLEKAKRNAMLLLAKMPHIIPHEDRVKLFRKFVQNEKAVMGLTESACASPRSALIVI 696
                         ||:.:             .::|:.|:.:..::...|          ...|.:
  Rat   369 -------------KRDLV-------------QKLKILRQELSQQQPQAG----------HCRIEV 397

  Fly   697 HRDRIVEDGYRQLAAQPTQALKGVIRVRFINQQGLHEAGIDQDGVFKEFLEETIKKVFDPSLNLF 761
            .|:.|.|:.|||:.....:.|...:.::|..::||     |..||.:|:|.....::.:|...||
  Rat   398 SREEIFEESYRQVMKMRPKDLWKRLMIKFRGEEGL-----DYGGVAREWLYLLSHEMLNPYYGLF 457

  Fly   762 KTTSDQ--RLYPSPISYVQDNHLELFEFVGRMLGKAVYEGIVVDVPFASFFLSQLLGQTQQALYS 824
            :.:.|.  .|..:|.|.|...||..|.||||::|.||:.|..:|..|...|..||||::     .
  Rat   458 QYSRDDIYTLQINPDSAVNPEHLSYFHFVGRIMGMAVFHGHYIDGGFTLPFYKQLLGKS-----I 517

  Fly   825 CMDELPSLDNELYRSLTFIKHYKQDVSD-LNLTFSVDQDVMGKIVTLALHPGGKARVVNDHNKLV 888
            .:|::..:|.:|:.||.:|  .:.|::. |:.||.|:.:..|:|:...|.|.||:..|.:.||..
  Rat   518 TLDDMELVDPDLHNSLVWI--LENDITGVLDHTFCVEHNAYGEIIQHELKPNGKSIPVTEENKKE 580

  Fly   889 YIHYMAFFHMNTQIREQTIAFNRGFRSIVNPEWLSLFSPPELQRLISGDTSPLDLKDLQKHTHYY 953
            |:.....:.....|..|.:|..:||..::....|..|...||:.:|.| ...:|:.|.:.:|...
  Rat   581 YVRLYVNWRFLRGIEAQFLALQKGFNEVIPQHLLKTFDEKELELIICG-LGKIDVSDWKANTRLK 644

  Fly   954 GGFHDTHQVVCWLWDILAKDFTEEERKLFLKFVTSCSKPPLLGFAHLEPPFSIRCVEVSDDEDTG 1018
            ....|:: ||.|.|..: :.|.||.|...|:|||..|:.||.||..|:
  Rat   645 HCTPDSN-VVKWFWKAV-ELFDEERRARLLQFVTGSSRVPLQGFKALQ----------------- 690

  Fly  1019 DTIGSVIRGFFAIRKKDP-LNRLPTSSTCFNLLKLPNYQKKSTLRDKLRYAVSSNTGF 1075
               |:.....|.|.:.|. .|.||.:.||||.:.:|.|:....|.:||..|:....||
  Rat   691 ---GAAGPRLFTIHQIDACTNNLPKAHTCFNRIDIPPYESYEKLYEKLLTAIEETCGF 745

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG5087	NP_648279.1	IQCD	20..50	CDD:467745
		HECTc	694..1076	CDD:238033	115/386 (30%)
Smurf2	NP_001100531.1	C2_Smurf-like	13..137	CDD:176028	23/141 (16%)
		PRP40	155..>236	CDD:227435	11/80 (14%)
		WW	159..188	CDD:459800	2/28 (7%)
		WW	252..283	CDD:197736	6/30 (20%)
		WW	298..330	CDD:197736	4/31 (13%)
		HECTc	393..745	CDD:238033	113/386 (29%)