DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5087 and Wwp1

DIOPT Version :9

Sequence 1:	NP_648279.1	Gene:	CG5087 / 39035	FlyBaseID:	FBgn0035953	Length:	1078	Species:	Drosophila melanogaster
Sequence 2:	XP_006237992.1	Gene:	Wwp1 / 297930	RGDID:	1311734	Length:	968	Species:	Rattus norvegicus

Alignment Length:	457	Identity:	131/457 - (28%)
Similarity:	207/457 - (45%)	Gaps:	55/457 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   625 KHWLIPEVKPSTFINDLEKAKRNAMLLLAKMPHIIPHED--RVKL--FRKFVQNEKAVMGLTESA 685
            ::::....:.:||     |..||....:.|....|.:|.  |.||  ||...|:.
  Rat   558 RYFVDHNTRTTTF-----KDPRNGKSSVTKGGPQIAYERSFRWKLAHFRYLCQSN---------- 607

  Fly   686 CASPRSALIVIHRDRIVEDGYRQLAAQPTQALKGVIRVRFINQQGLHEAGIDQDGVFKEFLEETI 750
             |.|....|.:.|..:.||.::|:.|.....|:..:.|.|..::||     |..|:.:|:.....
  Rat   608 -ALPSHVKINVSRQTLFEDSFQQIMALKPYDLRRRLYVIFRGEEGL-----DYGGLAREWFFLLS 666

  Fly   751 KKVFDPSLNLFKTTSDQR--LYPSPISYVQDNHLELFEFVGRMLGKAVYEGIVVDVPFASFFLSQ 813
            .:|.:|...||:......  |..:|.|.:..:||..|.|:||.:..|::.|..:|..|:..|..:
  Rat   667 HEVLNPMYCLFEYAGKNNYCLQINPASTINPDHLSYFCFIGRFIAMALFHGKFIDTGFSLPFYKR 731

  Fly   814 LLGQTQQALYSCMDELPSLDNELYRSLTFIKHYKQDVSDLNLTFSVDQDVMGKIVTLALHPGGKA 878
            :|.:.     ..:.:|.|:|.|.|.||.:|:....:...|.:.||||.:::||:.:..|..||..
  Rat   732 MLSKK-----LTIKDLESIDTEFYNSLIWIRDNNIEECGLEMYFSVDMEILGKVTSHDLKLGGSN 791

  Fly   879 RVVNDHNKLVYIHYMAFFHMNTQIREQTIAFNRGFRSIVNPEWLSLFSPPELQRLISGDTSPLDL 943
            .:|.:.||..||..|..:..:..::|||.||..||..:|..:||..|...||:.::.| ...:||
  Rat   792 ILVTEENKDEYIGLMTEWRFSRGVQEQTKAFLDGFNEVVPLQWLQYFDEKELEVMLCG-MQEVDL 855

  Fly   944 KDLQKHTHYYGGFHDTHQVVCWLWDILAKDFTEEERKLFLKFVTSCSKPPLLGFAHLEPPFSIRC 1008
            .|.|::|.|.....::.|:: |.|..: |:...|.|...|:|||...:.||.|||.|
  Rat   856 ADWQRNTVYRHYTRNSKQII-WFWQFV-KETDNEVRMRLLQFVTGTCRLPLGGFAEL-------- 910

  Fly  1009 VEVSDDEDTGDTIGSVIRGFFAIRKKDPLNRLPTSSTCFNLLKLPNYQKKSTLRDKLRYAVSSNT 1073
                        :||.....|.|.|......||.|.||||.|.||.|:....|::||.:|:....
  Rat   911 ------------MGSNGPQKFCIEKVGKDTWLPRSHTCFNRLDLPPYKSYEQLKEKLLFAIEETE 963

  Fly  1074 GF 1075
            ||
  Rat   964 GF 965

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5087	NP_648279.1	HECTc	694..1076	CDD:238033	115/384 (30%)
CG5087	NP_648279.1	HECTc	718..1075	CDD:214523	106/358 (30%)
Wwp1	XP_006237992.1	C2_E3_ubiquitin_ligase	67..190	CDD:175988
		PARM	243..>400	CDD:293666
		WW	397..426	CDD:278809
		WW	429..458	CDD:278809
		WW	504..533	CDD:278809
		WW	545..574	CDD:238122	3/20 (15%)
		HECTc	614..966	CDD:238033	115/385 (30%)
		HECTc	637..965	CDD:214523	107/360 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810