DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG5087 and HERC4

DIOPT Version :10

Sequence 1:NP_648279.1 Gene:CG5087 / 39035 FlyBaseID:FBgn0035953 Length:1078 Species:Drosophila melanogaster
Sequence 2:XP_011537894.1 Gene:HERC4 / 26091 HGNCID:24521 Length:1081 Species:Homo sapiens


Alignment Length:715 Identity:162/715 - (22%)
Similarity:287/715 - (40%) Gaps:152/715 - (21%)


- Green bases have known domain annotations that are detailed below.


  Fly   405 GDLLKQINLNYERIEFQ---SPQQPSISNLLRRALERSSTRGVNLMGVASSKQSKQQWRKLDSAE 466
            |.....:::|..|:.|.   .|..|.||..:..:||:      ||:...:|        .|...|
Human   476 GTRFSGVDMNAARLLFHKLIQPDHPQISQQVAASLEK------NLIPKLTS--------SLPDVE 526

  Fly   467 VVQVSRICGMYYAAL---------NTLSQMKLDILTGICYSDNVLYDIWLLITSLGPNCGMKEYL 522
            .::       :|..|         |..:.:.:...|.:...:                   |..|
Human   527 ALR-------FYLTLPECPLMSDSNNFTTIAIPFGTALVNLE-------------------KAPL 565

  Fly   523 ELLKSETNLQKPQ--TAMLMLFCDCMTHYVTILDEHEMYTEQNPFKLNDYVLLTYFLNNILYKLI 585
            ::|::..::.:|.  ..::.||.:.:.|.:.:.......:|:..|  |.::.....:..||:: :
Human   566 KVLENWWSVLEPPLFLKIVELFKEVVVHLLKLYKIGIPPSERRIF--NSFLHTALKVLEILHR-V 627

  Fly   586 NDNLLAGAKNIVQHPVFLSLHTLMLCLYRRDCRRPFTPPKHWL------------IPEVK--PST 636
            |:.:    ..|:|:..|. :|.:...:   |.|..:.   :|:            :.|:.  |.|
Human   628 NEKM----GQIIQYDKFY-IHEVQELI---DIRNDYI---NWVQQQAYGMDVNHGLTELADIPVT 681

  Fly   637 -----FINDLEKAKRNAM----LLLAKMPHIIPHEDRV-KLFRKFVQNEKAVMGLTESACASPRS 691
                 |:.|.: ||...:    :|..:|.....|...| .||...:::....:            
Human   682 ICTYPFVFDAQ-AKTTLLQTDAVLQMQMAIDQAHRQNVSSLFLPVIESVNPCL------------ 733

  Fly   692 ALIVIHRDRIVEDGYRQLAAQPTQALKGVIRVRFINQQGLHEAGIDQDGVFKEFLEETIKKVFDP 756
             ::|:.|:.||.|....|........|..::|.|:.     |..:|..||.|||....::::.||
Human   734 -ILVVRRENIVGDAMEVLRKTKNIDYKKPLKVIFVG-----EDAVDAGGVRKEFFLLIMRELLDP 792

  Fly   757 SLNLFKTTSDQRLYPSPISYVQDNHLELFEFVGRMLGKAVYEGIVVDVPFASFFLSQLLGQTQQA 821
            ...:|:...|.||........:|:  :||..:|.:.|.|:|...:||:.|......:||.:... 
Human   793 KYGMFRYYEDSRLIWFSDKTFEDS--DLFHLIGVICGLAIYNCTIVDLHFPLALYKKLLKKKPS- 854

  Fly   822 LYSCMDELPSLDNELYRSLTFIKHYKQDVSD----LNLTFSVDQDVMGKIVTLALHPGGKARVVN 882
                :|:|..|..::.||:..:..|.:|..:    ||.|.:|:.....::..|.|:  |....||
Human   855 ----LDDLKELMPDVGRSMQQLLDYPEDDIEETFCLNFTITVENFGATEVKELVLN--GADTAVN 913

  Fly   883 DHNKLVYIHYMAFFHMNTQIREQTIAFNRGFRSIVNPEWLSLFSPPELQRLISGDTSPLDLKDLQ 947
            ..|:..::.....:..|..:.....||:.||..:...:.|.||.|.|||.::.|:|: .|.|:|:
Human   914 KQNRQEFVDAYVDYIFNKSVASLFDAFHAGFHKVCGGKVLLLFQPNELQAMVIGNTN-YDWKELE 977

  Fly   948 KHTHYYGGFHDTHQVVCWLWDILAKDFTEEERKLFLKFVTSCSKPPLLGFAHLEPPFSIRCVEVS 1012
            |:|.|.|.:...|..:...|::. .:...|::|.||.|:|...:.|:||...|:...        
Human   978 KNTEYKGEYWAEHPTIKIFWEVF-HELPLEKKKQFLLFLTGSDRIPILGMKSLKLVI-------- 1033

  Fly  1013 DDEDTGDTIGSVIRGFFAIRKKDPLNRLPTSSTCFNLLKLPNYQKKSTLRDKLRYAVSSNTGFEL 1077
              :.||.  |.              ..||.|.||||||.||.|.:|.|||.||..|:..|.||.|
Human  1034 --QSTGG--GE--------------EYLPVSHTCFNLLDLPKYTEKETLRSKLIQAIDHNEGFSL 1080

  Fly  1078  1077
            Human  1081  1080

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG5087NP_648279.1 IQCD 20..50 CDD:467745
HECTc 694..1076 CDD:238033 108/385 (28%)
HERC4XP_011537894.1 ATS1 3..362 CDD:444065
HECTc 733..1079 CDD:238033 108/400 (27%)
Blue background indicates that the domain is not in the aligned region.

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