DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5087 and Magi3

DIOPT Version :9

Sequence 1:	NP_648279.1	Gene:	CG5087 / 39035	FlyBaseID:	FBgn0035953	Length:	1078	Species:	Drosophila melanogaster
Sequence 2:	NP_620784.3	Gene:	Magi3 / 245903	RGDID:	621362	Length:	1470	Species:	Rattus norvegicus

Alignment Length:	196	Identity:	36/196 - (18%)
Similarity:	68/196 - (34%)	Gaps:	65/196 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   198 CCNIQGH------------------LVQHDFYKIMRLVLIRGTVREELSVKPVTLVAIITLCLRP 244
            ||.:.|.                  |...|...::|      ..||.:.:|.|....:|...||.
  Rat    59 CCVVSGKAPSPGDVLLEVNGTPVSGLTNRDTLAVIR------HFREPIRLKTVKPGKVINKDLRH 117

  Fly   245 LIDGNFSRNLLAKFLSEIL-------------------SVPALIYHLQQSVPQCLEQFSSM---G 287
            .:...|.:..:...|.:::                   .||.:.|:...     :|||.::   |
  Rat   118 YLSLQFQKGSIDHKLQQVIRDNLYLRTIPCTTRAPRDGEVPGVDYNFIS-----VEQFKALEESG 177

  Fly   288 LLKKALSISGDVQWFEEFGTSMPGTKSLAFLGNIVN--LFNIDGQGESKELAYPLLTETTTSLLE 350
            .|.::.:..|:.     :||..|..:...|..:.|:  ||:.:...||:.       :.|||:.:
  Rat   178 ALLESGTYDGNF-----YGTPKPPAEPSPFQPDPVDQVLFDNEFDTESQR-------KRTTSVSK 230

  Fly   351 L 351
            :
  Rat   231 M 231

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5087	NP_648279.1	HECTc	694..1076	CDD:238033
CG5087	NP_648279.1	HECTc	718..1075	CDD:214523
Magi3	NP_620784.3	Interaction with ADRB1 and TGFA. /evidence=ECO:0000269\|PubMed:16316992	18..108		10/54 (19%)
		PDZ_signaling	24..103	CDD:238492	8/49 (16%)
		NK	125..>199	CDD:418433	13/83 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	184..266		13/60 (22%)
		HUL4	<211..>373	CDD:227354	7/28 (25%)
		WW	299..329	CDD:238122
		WW	345..375	CDD:238122
		Interaction with PTEN. /evidence=ECO:0000250	413..495
		PDZ	416..496	CDD:214570
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	550..575
		PDZ	578..659	CDD:214570
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	665..700
		PDZ	729..812	CDD:214570
		Interaction with ADGRB1. /evidence=ECO:0000250	729..811
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	818..847
		PDZ_signaling	851..936	CDD:238492
		Interaction with LPAR2 and GRIN2B. /evidence=ECO:0000250	852..939
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	939..976
		PDZ_signaling	1023..1101	CDD:238492
		PTZ00112	1115..>1405	CDD:240274
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1124..1146
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1167..1470
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900