DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5087 and NEDD4L

DIOPT Version :9

Sequence 1:	NP_648279.1	Gene:	CG5087 / 39035	FlyBaseID:	FBgn0035953	Length:	1078	Species:	Drosophila melanogaster
Sequence 2:	XP_006722489.1	Gene:	NEDD4L / 23327	HGNCID:	7728	Length:	1019	Species:	Homo sapiens

Alignment Length:	427	Identity:	121/427 - (28%)
Similarity:	207/427 - (48%)	Gaps:	50/427 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly   655 MPHIIPHEDRVKLFRKFVQNEKAVMGLTESACASPRSALIVIHRDRIVEDGYRQ-LAAQPTQALK 718
            :|:....:.:...|||.::....:          |....:.:||:.|.|:.||: ::.:....||
Human   635 VPYSREFKQKYDYFRKKLKKPADI----------PNRFEMKLHRNNIFEESYRRIMSVKRPDVLK 689

  Fly   719 GVIRVRFINQQGLHEAGIDQDGVFKEFLEETIKKVFDPSLNLFK--TTSDQRLYPSPIS-YVQDN 780
            ..:.:.|.:::||     |..||.:|:.....|::|:|...||:  .|.:..|..:|.| ...::
Human   690 ARLWIEFESEKGL-----DYGGVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNED 749

  Fly   781 HLELFEFVGRMLGKAVYEGIVVDVPFASFFLSQLLGQTQQALYSCMDELPSLDNELYRSLTFIKH 845
            ||..|.|:||:.|.||:.|.::|..|...|...:||:     ...::::.|:|:|.|.||.:|
Human   750 HLSYFTFIGRVAGLAVFHGKLLDGFFIRPFYKMMLGK-----QITLNDMESVDSEYYNSLKWI-- 807

  Fly   846 YKQDVSDLNLTFSVDQDVMGKIVTLALHPGGKARVVNDHNKLVYIHYMAFFHMNTQIREQTIAFN 910
            .:.|.::|:|.|.:|::..|:...:.|.|.|...:|.:.||..||..:..:....::::|..||.
Human   808 LENDPTELDLMFCIDEENFGQTYQVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFL 872

  Fly   911 RGFRSIVNPEWLSLFSPPELQRLISGDTSPLDLKDLQKHTHYYGGFHDTHQVVCWLWD-ILAKDF 974
            .||..::..:.:.:|...||:.|:.| ...:|:.|.::|:.|..|:...|.|:.|.|. :|..|
Human   873 EGFTELLPIDLIKIFDENELELLMCG-LGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMD- 935

  Fly   975 TEEERKLFLKFVTSCSKPPLLGFAHLEPPFSIRCVEVSDDEDTGDTIGSVIRGFFAIRKKDPLNR 1039
             .|:|...|:|||..|:.|:.|||.|                    .||.....|.|.:.....:
Human   936 -AEKRIRLLQFVTGTSRVPMNGFAEL--------------------YGSNGPQLFTIEQWGSPEK 979

  Fly  1040 LPTSSTCFNLLKLPNYQKKSTLRDKLRYAVSSNTGFE 1076
            ||.:.||||.|.||.|:....||:||..||.:..|||
Human   980 LPRAHTCFNRLDLPPYETFEDLREKLLMAVENAQGFE 1016

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5087	NP_648279.1	HECTc	694..1076	CDD:238033	114/386 (30%)
CG5087	NP_648279.1	HECTc	718..1075	CDD:214523	106/360 (29%)
NEDD4L	XP_006722489.1	C2_NEDD4_NEDD4L	21..179	CDD:175999
		WW	224..250	CDD:278809
		WW	413..442	CDD:278809
		WW	526..556	CDD:238122
		WW	575..625	CDD:197736
		HECTc	662..1016	CDD:238033	114/388 (29%)
		HECTc	686..1015	CDD:214523	107/363 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810