Protein Alignment CG5087 and HECW1

DIOPT Version :10

• Sequence 1: NP_648279.1
• Gene: CG5087 / 39035
• FlyBaseID: FBgn0035953
• Length: 1078
• Species: Drosophila melanogaster
• Sequence 2: XP_016867371.1
• Gene: HECW1 / 23072
• HGNCID: 22195
• Length: 1639
• Species: Homo sapiens
• Alignment Length: 883
• Identity: 216/883 - (24%)
• Similarity: 336/883 - (38%)
• Gaps: 237/883 - (26%)

  Fly   223 VREELSVKPVTLVAIITLCLRPLIDGNFSRNLLAKFLS--EILSVPALIYHLQQSVPQCLEQFSS 285
            :|.|.|:.||....|..|...|.:          ||::  |..:|    .|...|   ....|:|
Human   965 LRREGSLSPVNSQKITLLLQSPAV----------KFITNPEFFTV----LHANYS---AYRVFTS 1012

  Fly   286 MGLLK-KALSISGDVQWFEEFGTSMPGTKSLAFLGNIVNLFNIDGQGESKELAYPLLTETTTSLL 349
            ...|| ..|.:..|.:.||.:..:..       |.|.:|:|                   ..:.|
Human  1013 STCLKHMILKVRRDARNFERYQHNRD-------LVNFINMF-------------------ADTRL 1051

  Fly   350 ELIPNTVTTKGVFTQWHELLGWHTPGPEPAQNQNVALIKKQFHMLWDHRCIKLLLGDLLKQINLN 414
            || |.               ||.....:..         |.|.:  ||                |
Human  1052 EL-PR---------------GWEIKTDQQG---------KSFFV--DH----------------N 1073

  Fly   415 YERIEFQSPQQPSISNLLRRALERSSTRGVNLMGVASSKQSKQQWRKLDSAEVVQVSRICG---- 475
            .....|..|:.|..:..|...|              :.:|..|:.|...:.|..:|||..|
Human  1074 SRATTFIDPRIPLQNGRLPNHL--------------THRQHLQRLRSYSAGEASEVSRNRGASLL 1124

  Fly   476 -----MYYAALNTLSQMKLDILTGICYSDNVLY-----DIWLLI----TSLGPNCGMKEYLELLK 526
                 ...||:.  ||.:.:.|. :.|:|.::.     :|:.::    .||..|..::|.:..::
Human  1125 ARPGHSLVAAIR--SQHQHESLP-LAYNDKIVAFLRQPNIFEMLQERQPSLARNHTLREKIHYIR 1186

  Fly   527 SETN--LQKPQTAMLMLFCDCMTHYVTILDEHEMYTEQNPFKLNDYVLLTYFLNNILYKLINDNL 589
            :|.|  |:|       |.||.                       |.|        ||..|..:.:
Human  1187 TEGNHGLEK-------LSCDA-----------------------DLV--------ILLSLFEEEI 1213

  Fly   590 LAGAKNIVQHPVFLSLHTLMLCLYR-RDCRRPFTPPKHWLIPEVKPSTFINDLEKAKRNAMLLLA 653
            ::..      |:..:.|.......| ..|..|...|.........||.:..|.|...||
Human  1214 MSYV------PLQAAFHPGYSFSPRCSPCSSPQNSPGLQRASARAPSPYRRDFEAKLRN------ 1266

  Fly   654 KMPHIIPHEDRVKLFRKFVQNEKAVMGLTESACASPRSALIVIHRDRIVEDGYRQLAAQPTQAL- 717
                         .:||.   |....|      ..|....::|.||.::|..:.|:.|...:.|
Human  1267 -------------FYRKL---EAKGFG------QGPGKIKLIIRRDHLLEGTFNQVMAYSRKELQ 1309

  Fly   718 KGVIRVRFINQQGLHEAGIDQDGVFKEFLEETIKKVFDPSLNLFKTTSDQ--RLYPSPISYVQDN 780
            :..:.|.|:.::||     |..|..:||.....:::|:|...||:.:::.  .:..||:|...:|
Human  1310 RNKLYVTFVGEEGL-----DYSGPSREFFFLLSQELFNPYYGLFEYSANDTYTVQISPMSAFVEN 1369

  Fly   781 HLELFEFVGRMLGKAVYEGIVVDVPFASFFLSQLLGQTQQALYSCMDELPSLDNELYRSLTFIKH 845
            |||.|.|.||:||.|:....::|..|...|...||     .|...:.:|..||.|.::||.::|
Human  1370 HLEWFRFSGRILGLALIHQYLLDAFFTRPFYKALL-----RLPCDLSDLEYLDEEFHQSLQWMK- 1428

  Fly   846 YKQDVSD-LNLTFSVDQDVMGKIVTLALHPGGKARVVNDHNKLVYIHYMAFFHMNTQIREQTIAF 909
             ..:::| |:|||:|:::|.|::....|..||....|.:.||..||..|..:.:...:.:||.|.
Human  1429 -DNNITDILDLTFTVNEEVFGQVTERELKSGGANTQVTEKNKKEYIERMVKWRVERGVVQQTEAL 1492

  Fly   910 NRGFRSIVNPEWLSLFSPPELQRLISGDTSPLDLKDLQKHTHYYGGFHDTHQVVCWLWDILAKDF 974
            .|||..:|:...:|:|...||:.:|:| |:.:||.|.:.:|.|.||:||.|.|:.|.|..:.: |
Human  1493 VRGFYEVVDSRLVSVFDARELELVIAG-TAEIDLNDWRNNTEYRGGYHDGHLVIRWFWAAVER-F 1555

  Fly   975 TEEERKLFLKFVTSCSKPPLLGFAHLEPPFSIRCVEVSDDEDTGDTIGSVIRGFFAIRKKDPLNR 1039
            ..|:|...|:|||..|..|..|||.|.....:|                    .|.|.|...:..
Human  1556 NNEQRLRLLQFVTGTSSVPYEGFAALRGSNGLR--------------------RFCIEKWGKITS 1600

  Fly  1040 LPTSSTCFNLLKLPNYQKKSTLRDKLRYAVSSNTGFEL 1077
            ||.:.||||.|.||.|...|.|.:||..||...:.|.|
Human  1601 LPRAHTCFNRLDLPPYPSYSMLYEKLLTAVEETSTFGL 1638

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG5087	NP_648279.1	IQCD	20..50	CDD:467745
		HECTc	694..1076	CDD:238033	123/385 (32%)
HECW1	XP_016867371.1	HECW_N	97..214	CDD:465177
		C2_NEDL1-like	237..373	CDD:176073
		PHA03169	<407..>531	CDD:223003
		WW	864..893	CDD:459800
		HECW1_helix	981..1047	CDD:465766	20/108 (19%)
		WW	1053..1084	CDD:197736	11/73 (15%)
		HECTc	1283..1637	CDD:238033	123/387 (32%)