DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5087 and HECW1

DIOPT Version :9

Sequence 1:	NP_648279.1	Gene:	CG5087 / 39035	FlyBaseID:	FBgn0035953	Length:	1078	Species:	Drosophila melanogaster
Sequence 2:	XP_016867371.1	Gene:	HECW1 / 23072	HGNCID:	22195	Length:	1639	Species:	Homo sapiens

Alignment Length:	883	Identity:	216/883 - (24%)
Similarity:	336/883 - (38%)	Gaps:	237/883 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   223 VREELSVKPVTLVAIITLCLRPLIDGNFSRNLLAKFLS--EILSVPALIYHLQQSVPQCLEQFSS 285
            :|.|.|:.||....|..|...|.:          ||::  |..:|    .|...|   ....|:|
Human   965 LRREGSLSPVNSQKITLLLQSPAV----------KFITNPEFFTV----LHANYS---AYRVFTS 1012

  Fly   286 MGLLK-KALSISGDVQWFEEFGTSMPGTKSLAFLGNIVNLFNIDGQGESKELAYPLLTETTTSLL 349
            ...|| ..|.:..|.:.||.:..:..       |.|.:|:|                   ..:.|
Human  1013 STCLKHMILKVRRDARNFERYQHNRD-------LVNFINMF-------------------ADTRL 1051

  Fly   350 ELIPNTVTTKGVFTQWHELLGWHTPGPEPAQNQNVALIKKQFHMLWDHRCIKLLLGDLLKQINLN 414
            || |.               ||.....:..         |.|.:  ||                |
Human  1052 EL-PR---------------GWEIKTDQQG---------KSFFV--DH----------------N 1073

  Fly   415 YERIEFQSPQQPSISNLLRRALERSSTRGVNLMGVASSKQSKQQWRKLDSAEVVQVSRICG---- 475
            .....|..|:.|..:..|...|              :.:|..|:.|...:.|..:|||..|
Human  1074 SRATTFIDPRIPLQNGRLPNHL--------------THRQHLQRLRSYSAGEASEVSRNRGASLL 1124

  Fly   476 -----MYYAALNTLSQMKLDILTGICYSDNVLY-----DIWLLI----TSLGPNCGMKEYLELLK 526
                 ...||:.  ||.:.:.|. :.|:|.::.     :|:.::    .||..|..::|.:..::
Human  1125 ARPGHSLVAAIR--SQHQHESLP-LAYNDKIVAFLRQPNIFEMLQERQPSLARNHTLREKIHYIR 1186

  Fly   527 SETN--LQKPQTAMLMLFCDCMTHYVTILDEHEMYTEQNPFKLNDYVLLTYFLNNILYKLINDNL 589
            :|.|  |:|       |.||.                       |.|        ||..|..:.:
Human  1187 TEGNHGLEK-------LSCDA-----------------------DLV--------ILLSLFEEEI 1213

  Fly   590 LAGAKNIVQHPVFLSLHTLMLCLYR-RDCRRPFTPPKHWLIPEVKPSTFINDLEKAKRNAMLLLA 653
            ::..      |:..:.|.......| ..|..|...|.........||.:..|.|...||
Human  1214 MSYV------PLQAAFHPGYSFSPRCSPCSSPQNSPGLQRASARAPSPYRRDFEAKLRN------ 1266

  Fly   654 KMPHIIPHEDRVKLFRKFVQNEKAVMGLTESACASPRSALIVIHRDRIVEDGYRQLAAQPTQAL- 717
                         .:||.   |....|      ..|....::|.||.::|..:.|:.|...:.|
Human  1267 -------------FYRKL---EAKGFG------QGPGKIKLIIRRDHLLEGTFNQVMAYSRKELQ 1309

  Fly   718 KGVIRVRFINQQGLHEAGIDQDGVFKEFLEETIKKVFDPSLNLFKTTSDQ--RLYPSPISYVQDN 780
            :..:.|.|:.::||     |..|..:||.....:::|:|...||:.:::.  .:..||:|...:|
Human  1310 RNKLYVTFVGEEGL-----DYSGPSREFFFLLSQELFNPYYGLFEYSANDTYTVQISPMSAFVEN 1369

  Fly   781 HLELFEFVGRMLGKAVYEGIVVDVPFASFFLSQLLGQTQQALYSCMDELPSLDNELYRSLTFIKH 845
            |||.|.|.||:||.|:....::|..|...|...||     .|...:.:|..||.|.::||.::|
Human  1370 HLEWFRFSGRILGLALIHQYLLDAFFTRPFYKALL-----RLPCDLSDLEYLDEEFHQSLQWMK- 1428

  Fly   846 YKQDVSD-LNLTFSVDQDVMGKIVTLALHPGGKARVVNDHNKLVYIHYMAFFHMNTQIREQTIAF 909
             ..:::| |:|||:|:::|.|::....|..||....|.:.||..||..|..:.:...:.:||.|.
Human  1429 -DNNITDILDLTFTVNEEVFGQVTERELKSGGANTQVTEKNKKEYIERMVKWRVERGVVQQTEAL 1492

  Fly   910 NRGFRSIVNPEWLSLFSPPELQRLISGDTSPLDLKDLQKHTHYYGGFHDTHQVVCWLWDILAKDF 974
            .|||..:|:...:|:|...||:.:|:| |:.:||.|.:.:|.|.||:||.|.|:.|.|..:.: |
Human  1493 VRGFYEVVDSRLVSVFDARELELVIAG-TAEIDLNDWRNNTEYRGGYHDGHLVIRWFWAAVER-F 1555

  Fly   975 TEEERKLFLKFVTSCSKPPLLGFAHLEPPFSIRCVEVSDDEDTGDTIGSVIRGFFAIRKKDPLNR 1039
            ..|:|...|:|||..|..|..|||.|.....:|                    .|.|.|...:..
Human  1556 NNEQRLRLLQFVTGTSSVPYEGFAALRGSNGLR--------------------RFCIEKWGKITS 1600

  Fly  1040 LPTSSTCFNLLKLPNYQKKSTLRDKLRYAVSSNTGFEL 1077
            ||.:.||||.|.||.|...|.|.:||..||...:.|.|
Human  1601 LPRAHTCFNRLDLPPYPSYSMLYEKLLTAVEETSTFGL 1638

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5087	NP_648279.1	HECTc	694..1076	CDD:238033	123/385 (32%)
CG5087	NP_648279.1	HECTc	718..1075	CDD:214523	116/359 (32%)
HECW1	XP_016867371.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810