Protein Alignment CG5087 and Hectd2

DIOPT Version :10

• Sequence 1: NP_648279.1
• Gene: CG5087 / 39035
• FlyBaseID: FBgn0035953
• Length: 1078
• Species: Drosophila melanogaster
• Sequence 2: NP_001156943.1
• Gene: Hectd2 / 226098
• MGIID: 2442663
• Length: 775
• Species: Mus musculus
• Alignment Length: 856
• Identity: 189/856 - (22%)
• Similarity: 317/856 - (37%)
• Gaps: 214/856 - (25%)

  Fly   329 GQGESKELAYPLLTETTTSLLELIPNTVTTKGVFTQWHELLGWHTPGPEPAQNQNVALIKKQFHM 393
            |:...:|...|::|....:.|:.     .:||..:.:...:...|...|.|:|::     ...|:
Mouse    26 GKEPEREKLPPIVTAGAAAGLDR-----GSKGQISTFSSFVSTVTQKKEAAENRS-----SPTHL 80

  Fly   394 ----LWDHRCIKLLLGDLLKQINLNYERI----------EFQSPQQPSISNLLRRALERSSTRG- 443
                :.:.|.:..:..|:.::..::.|.:          |...|.||.........||::...|
Mouse    81 ALPNIRNVRDLPPICLDVRQKQRMSVEALPSEVKVPPLPEPSLPSQPKTVKDFEEDLEKAEATGN 145

  Fly   444 --------------VNLMGVASSKQSKQQWRKLDSAEVVQVSRICGMYYAALNTLSQMKLDILTG 494
                          ...:..|..|.:...:..::.:. :..:.:..::.|.|||...::..:|.|
Mouse   146 WKTVHAFYITAFDSFTELNTAFKKDATASFNTIEDSG-LNANLVNAVFDALLNTPQDIQKSVLKG 209

  Fly   495 ICYSDNVLYDIWLLITSLGPNC--GMKEYLELLKSETNLQKPQ---TAMLMLFCDCMTHYVTILD 554
            |.   |.|...|     .||..  .::.|..|      ||.||   |:..:::...:....|:::
Mouse   210 II---NSLLQEW-----KGPRTKDDLRAYFIL------LQNPQFNITSTYVIYAHLLRQIATLVE 260

  Fly   555 EHEMYTEQNPFKLNDYVLLTYFLNNILYKLINDNLLAGAKNIVQHPV-FLSLHTLMLCLYRRDCR 618
            .             |:..|.::|..:..|..        |.:|:..: |:||...
Mouse   261 A-------------DHHFLVHWLKKLSQKKF--------KQLVERLLQFVSLRLF---------- 294

  Fly   619 RPFTPPKH-------WLIPEVKPSTFINDLEKAKRNAMLLLAK---MPHIIPHE-------DRVK 666
             |..|.:.       |.||..           ||..|:|..|.   .|.::|:.       |.:.
Mouse   295 -PAKPEEFPPLTKCTWWIPSA-----------AKVLALLNTANNLVHPPLVPYTDFYNSTLDHID 347

  Fly   667 LFRKF------------------------------VQNEK-------AVMGLTESACASPRSAL- 693
            |..::                              :|.:.       |...|.:......|..:
Mouse   348 LMEEYHTWQSFGNSHSRFSFCQYPFVISIAAKKIIIQRDSEQQMISIARQSLVDKVSRRQRPDMN 412

  Fly   694 -----IVIHRDRIVEDGYRQLAAQPTQALKGVIRVRFINQQGLHEAGIDQDGVFKEFLEETIKKV 753
                 :.:.|..:|.|...:|..:... ||..::|.|:.     |||:|..|:.||:....|:::
Mouse   413 MLFLNMKVRRTHLVSDSLDELTRKRAD-LKKKLKVTFVG-----EAGLDMGGLTKEWFLLLIRQI 471

  Fly   754 FDPSLNLFKTTSDQRLYPSPISYVQDNHLELFEFVGRMLGKAVYEGIVVDVPFASFFLSQLLG-- 816
            |.|...:|....|...:... |:..||:.| |..||.::|.|||..|.:|:.|......:||.
Mouse   472 FHPDYGMFTYHKDSHCHWFS-SFKCDNYSE-FRLVGILMGLAVYNSITLDIRFPPCCYKKLLSPP 534

  Fly   817 ------QTQQALYS-CMDELPSLDNELYRSLTFIKHYKQDV-SDLNLTFSVDQDVMGKIVTLALH 873
                  .|...:.| .:|:|..:..||...|..:..|:.:| .|...||.|.|:..|.|.:..|.
Mouse   535 VVPSDQSTPVGICSVTIDDLCQVMPELAHGLKELLSYEGNVEEDFYSTFQVFQEEFGVIKSYNLK 599

  Fly   874 PGGKARVVNDHNKLVYIHYMAFFHMNTQIREQTIAFNRGFRSIVNPEWLSLFSPPELQRLISGDT 938
            |||....|.:.|:..|:.....|.:|..|.:|..||..||.|:.....|.|..|.|::.|:.|
Mouse   600 PGGDKIPVTNQNRREYVQLYTDFLLNKSIYKQFAAFYCGFHSVCASNALMLLRPEEVEILVCG-- 662

  Fly   939 SP-LDLKDLQKHTHYYGGFHDTHQVVCWLWDILAKDFTEEERKLFLKFVTSCSKPPLLGFAHLEP 1002
            || ||:..||:.|. |.|:..|...:.:.||::. .|..|.:|..|.|.|...:.|:.|.|.|.
Mouse   663 SPELDMHALQRSTQ-YDGYAKTDLTIRYFWDVVL-GFPLELQKKLLHFTTGSDRVPVGGMADLN- 724

  Fly  1003 PFSIRCVEVSDDEDTGDTIGSVIRGFFAIRKKD-PLNRLPTSSTCFNLLKLPNYQKKSTLRDKLR 1066
                                      |.|.|.: ..|.||.:.||||.|.||.|:.|..|:.||.
Mouse   725 --------------------------FKISKNETSTNWLPVAHTCFNQLCLPPYKSKKDLKQKLI 763

  Fly  1067 YAVSSNTGFEL 1077
            ..:|::.||.|
Mouse   764 IGISNSEGFGL 774

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG5087	NP_648279.1	IQCD	20..50	CDD:467745
		HECTc	694..1076	CDD:238033	116/393 (30%)
Hectd2	NP_001156943.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..51		5/29 (17%)
		HECTc	416..773	CDD:238033	116/395 (29%)