DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5087 and Ube3a

DIOPT Version :9

Sequence 1:	NP_648279.1	Gene:	CG5087 / 39035	FlyBaseID:	FBgn0035953	Length:	1078	Species:	Drosophila melanogaster
Sequence 2:	NP_001380595.1	Gene:	Ube3a / 22215	MGIID:	105098	Length:	870	Species:	Mus musculus

Alignment Length:	729	Identity:	177/729 - (24%)
Similarity:	309/729 - (42%)	Gaps:	146/729 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   435 ALERSSTRGVNLMGVASSKQSKQQWRKLDSAEV-VQVSRICGMYYAALNTLSQMKLDILTGICY- 497
            |:|..|....:.||  .|.|.....:||...:| |.:..| ...|::|....:::...|..:.|
Mouse   197 AMEEDSEASSSRMG--DSSQGDNNVQKLGPDDVTVDIDAI-RRVYSSLLANEKLETAFLNALVYL 258

  Fly   498 SDNVLYDI-WLLITSLGPNCGMKEYLEL---LKSETNLQKPQ--TAMLMLFCDCM---------- 546
            |.||..|: :..:.:..||     ||.|   :...:||..|:  ...|.|||..|
Mouse   259 SPNVECDLTYHNVYTRDPN-----YLNLFIIVMENSNLHSPEYLEMALPLFCKAMCKLPLEAQGK 318

  Fly   547 -----THYVTILDEHEMYTEQNPFKLNDYVLLTYFLNNILYKLINDN--LLAGAK--------NI 596
                 :.|........|.|.|   :|..|.:::...|:  ..|:||:  ::|.:|        |:
Mouse   319 LIRLWSKYSADQIRRMMETFQ---QLITYKVISNEFNS--RNLVNDDDAIVAASKCLKMVYYANV 378

  Fly   597 V-------------QHPV----FLSLHTLM------------------LCLYRRDCRRP------ 620
            |             :.|:    .|:|..|:                  |.:...|||:|
Mouse   379 VGGDVDTNHNEEDDEEPIPESSELTLQELLGDERRNKKGPRVDPLETELGVKTLDCRKPLISFEE 443

  Fly   621 -FTPPKHWLIPEVKPSTFINDLEKAKRNAM----LLLAKMPHI-IPHEDRVKLFRKFVQNEKAVM 679
             ...|.:.::...|..||.....:.|.:.|    :|.|...:: :.:::|::::.:  :....:.
Mouse   444 FINEPLNDVLEMDKDYTFFKVETENKFSFMTCPFILNAVTKNLGLYYDNRIRMYSE--RRITVLY 506

  Fly   680 GLTESACASPRSALIVIHRDRIVEDG---YRQLAAQPTQALKGVIRVRFINQQGLHEAGIDQDGV 741
            .|.:....:|...| .:.||.|::|.   ...:|.:....||..:.|.|..:|     |:|:.||
Mouse   507 SLVQGQQLNPYLRL-KVRRDHIIDDALVRLEMIAMENPADLKKQLYVEFEGEQ-----GVDEGGV 565

  Fly   742 FKEFLEETIKKVFDPSLNLFKTTSDQRLY-PSPISYVQDNHLELFEFVGRMLGKAVYEGIVVDVP 805
            .|||.:..::::|:|.:.:|......:|: .:|.|:..:..   |..:|.:||.|:|...::||.
Mouse   566 SKEFFQLVVEEIFNPDIGMFTYDEATKLFWFNPSSFETEGQ---FTLIGIVLGLAIYNNCILDVH 627

  Fly   806 FASFFLSQLLGQTQQALYSCMDELPSLDNELYRSLTFIKHYKQDV-SDLNLTFSVDQ-DVMGKIV 868
            |......:|:|:.     ....:|......||:||..:..|:..| .|:.:||.:.| |:.|..:
Mouse   628 FPMVVYRKLMGKK-----GTFRDLGDSHPVLYQSLKDLLEYEGSVEDDMMITFQISQTDLFGNPM 687

  Fly   869 TLALHPGGKARVVNDHNKLVYIHYMAFFHMNTQIREQTIAFNRGFRSIVNPEWLS-LFSPPELQR 932
            ...|...|....:.:.|:..:::..:.:.:|..:.:|..||.|||..:.|...|. ||.|.|::.
Mouse   688 MYDLKENGDKIPITNENRKEFVNLYSDYILNKSVEKQFKAFRRGFHMVTNESPLKYLFRPEEIEL 752

  Fly   933 LISGDTSPLDLKDLQKHTHYYGGFHDTHQVVCWLWDILAKDFTEEERKLFLKFVTSCSKPPLLGF 997
            ||.|..: ||.:.|::.|.|.||:.....|:...|:|: ..||:|:::|||:|.|...:.|:.|.
Mouse   753 LICGSRN-LDFQALEETTEYDGGYTRESVVIREFWEIV-HSFTDEQKRLFLQFTTGTDRAPVGGL 815

  Fly   998 AHLEPPFSIRCVEVSDDEDTGDTIGSVIRGFFAIRKKDP-LNRLPTSSTCFNLLKLPNYQKKSTL 1061
            ..|:                           ..|.|..| ..|||||.||||:|.||.|..|..|
Mouse   816 GKLK---------------------------MIIAKNGPDTERLPTSHTCFNVLLLPEYSSKEKL 853

  Fly  1062 RDKLRYAVSSNTGF 1075
            :::|..|::...||
Mouse   854 KERLLKAITYAKGF 867

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5087	NP_648279.1	HECTc	694..1076	CDD:238033	109/390 (28%)
CG5087	NP_648279.1	HECTc	718..1075	CDD:214523	101/361 (28%)
Ube3a	NP_001380595.1	AZUL	27..81	CDD:406862
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	171..223		8/27 (30%)
		HECTc	518..868	CDD:238033	110/393 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810