Protein Alignment CG5087 and Wwc1

DIOPT Version :9

• Sequence 1: NP_648279.1
• Gene: CG5087 / 39035
• FlyBaseID: FBgn0035953
• Length: 1078
• Species: Drosophila melanogaster
• Sequence 2: NP_740749.1
• Gene: Wwc1 / 211652
• MGIID: 2388637
• Length: 1104
• Species: Mus musculus
• Alignment Length: 704
• Identity: 134/704 - (19%)
• Similarity: 217/704 - (30%)
• Gaps: 272/704 - (38%)

  Fly   389 KQFHMLWDHRC---IKLLLG---------DLLK--------QIN-LNYERIEFQSPQQPSISNLL 432
            :|.|.:|:|:.   :.|:.|         ::||        ::| |..|.:..|...|
Mouse   129 QQLHAVWEHKLGSQVSLVSGSSSSSKYDPEILKAEIATAKSRVNKLKREMVHLQHELQ------- 186

  Fly   433 RRALERSSTRGVNLMGVASSKQSKQQ-WRKLDSAEVVQVSRICGMYYAALNTLSQMKLDILTGIC 496
                  ...||...:.....:.|..| ..|||.|:            |.|.....:|..|
Mouse   187 ------FKERGFQTLKKIDERMSDAQGGYKLDEAQ------------AVLRETKAIKKAI----- 228

  Fly   497 YSDNVLYDIWLLITSLGPNCGMKEYLELLKSETNLQKPQTAMLMLFCDCMTHYVTILDEH-EMYT 560
                              .||.||..:|:||        .|||      ...:.|....| ::::
Mouse   229 ------------------TCGEKEKQDLIKS--------LAML------KDGFRTDRGSHSDLWS 261

  Fly   561 EQNPFKLNDYVLLTYFLNNILYKLINDNLLAGAKNIVQHPVFLSLHTLMLCLYRRDCRRPFTPPK 625
            ..:..:.:.:.:...||:......|:.:....:.|.:...|.|.|.
Mouse   262 SSSSLESSSFPMPKQFLDVSSQTDISGSFSTSSNNQLAEKVRLRLR------------------- 307

  Fly   626 HWLIPEVKPSTFINDLEKAKR---NAMLLLAKM-----PHIIPHE-DRVKLFRKFVQNEKAVMGL 681
                           .|:|||   |..:.|||:     |.::..| ||:.|.     |||..: |
Mouse   308 ---------------YEEAKRRIANLKIQLAKLDSEAWPGVLDSERDRLILI-----NEKEEL-L 351

  Fly   682 TESACASPRS------ALIVIHRDRIVEDGYRQLAAQPTQ--ALKGVIRVRFINQQGLHEAGIDQ 738
            .|....|||.      ..:.:.|.|:.:|   ..||:.||  ||...:::.....|.:.|
Mouse   352 KEMRFISPRKWTQGEVEQLEMARRRLEKD---LQAARDTQSKALTERLKLNSKRNQLVRE----- 408

  Fly   739 DGVFKEFLEETIKKVFDPSLNLFKTTSDQRLYPSPISYVQDNHLELFEFVGRMLGKAVYEGIVVD 803
                   |||..::|......|...:|..:...|
Mouse   409 -------LEEATRQVATLHSQLKSLSSSMQSLSS------------------------------- 435

  Fly   804 VPFASFFLSQLLGQTQQALYSCMDEL--PSLDNELYRSLT--FIKHYKQDVSDLNLTFSVDQDVM 864
                        |.:..:|.|....|  .|||:....|.|  :...::|          :|.::.
Mouse   436 ------------GSSPGSLTSSRGSLAASSLDSSTSASFTDLYYDPFEQ----------LDSELQ 478

  Fly   865 GKIVTLAL------HPGG-----------KARVVNDHNKLVYIHYMAFFHMNTQIREQTIAFNRG 912
            .|:..|.|      .|.|           |.:.....::|     .|...::...|..|....|.
Mouse   479 SKVELLFLEGATGFRPSGCITTIHEDEVAKTQKAEGGSRL-----QALRSLSGTPRSMTSLSPRS 538

  Fly   913 FRSIVNPEWLSLFSPPELQRLISGDT--SPLDLKDLQKHTHYYGGFHDTHQVVCWLWDILAKDFT 975
            ..|..:|....|.:.|    |::||.  :||:.:|.:..|           .:|.|  .|....|
Mouse   539 SLSSPSPPCSPLITDP----LLTGDAFLAPLEFEDTELST-----------TLCEL--NLGGSGT 586

  Fly   976 EEERKLFLKFVTSCSKP-----PLLGFAHLEP--PFSIRCVE--VSDDEDTGDT 1020
            :|..:|        .:|     ||...|.:.|  ...:.||.  |||:...||:
Mouse   587 QERYRL--------EEPGPEGKPLGQAASVAPGCGLKVACVSAAVSDESVAGDS 632

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG5087	NP_648279.1	HECTc	694..1076	CDD:238033	69/361 (19%)
		HECTc	718..1075	CDD:214523	60/335 (18%)
Wwc1	NP_740749.1	WW	9..39	CDD:238122
		WW	55..84	CDD:278809
		ALDH-SF	378..>420	CDD:299846	13/56 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	429..449		4/62 (6%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	509..547		7/42 (17%)
		C2_Kibra	661..784	CDD:176062
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	822..949
		Interaction with histone H3. /evidence=ECO:0000250	836..1104
		Interaction with PRKCZ. /evidence=ECO:0000250	945..988
		ADDV motif	1102..1104

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900