Protein Alignment CG5087 and Hace1

DIOPT Version :10

• Sequence 1: NP_648279.1
• Gene: CG5087 / 39035
• FlyBaseID: FBgn0035953
• Length: 1078
• Species: Drosophila melanogaster
• Sequence 2: XP_006512697.1
• Gene: Hace1 / 209462
• MGIID: 2446110
• Length: 921
• Species: Mus musculus
• Alignment Length: 1117
• Identity: 247/1117 - (22%)
• Similarity: 409/1117 - (36%)
• Gaps: 351/1117 - (31%)

  Fly    96 RARERLERICRYIIKA----MESENTKLSYAALCLFKERSLPWIAHIKILLTNCLTLLPELKPEN 156
            ||.|:|.|:.|.:.:|    :..:|....|                         ||:|.:..:.
Mouse     3 RAMEQLNRLTRSLRRARTVELPEDNETAVY-------------------------TLMPMVMADQ 42

  Fly   157 HADSLSLALFLHTLVVFTAPKSWAILRNAQFEKLQPAMQKICCNIQGHLVQHDFYKIMRLVL-IR 220
            |. |:|                 .:|.|::|:                 |.:.|.::.|.:| |.
Mouse    43 HR-SVS-----------------ELLSNSKFD-----------------VNYAFGRVKRSLLHIA 72

  Fly   221 GTVREELSVKPVTLVAIITLCLRPLIDGNF------------SRNLLAKFLSEILSVPA------ 267
            .....         |..:.|.|:...:.|:            :||...|.:|::|...|
Mouse    73 ANCGS---------VECLVLLLKKGANPNYQDISGCTPLHLAARNGQKKCMSKLLEYSADVNICN 128

  Fly   268 -----------------LIYHLQQSVPQCLEQFSSMGLLKKALSIS------GDVQWFEEFGT-- 307
                             |::.|.|.|.. ::...:||  :.||.::      ..||...:.|.
Mouse   129 NEGLTAIHWLAVNGRTELLHDLVQHVTD-VDVEDAMG--QTALHVACQNGHKTTVQCLLDSGADI 190

  Fly   308 ---SMPGTKSLAFLGNIVNLFN---IDGQGESKELAYPLLTETTTSLLE---LIPNTVTTKGVFT 363
               ::.|...|.|....|.|..   |...|: ::.|..||......|.:   :.|..:..:|.:.
Mouse   191 NRPNVSGATPLYFACRRVCLIFWTWIHSHGQ-RDTAQILLLRGAKYLPDKNGVTPLDLCVQGGYG 254

  Fly   364 QWHE-LLGWHTPGPEPAQ-----NQNVALIKKQFHMLWDH-------RCIKLLL---------GD 406
            |..| |:.:|   |...|     .||..|.:.....:..|       :.:|:|.         |.
Mouse   255 QTCEVLIQYH---PRLFQTIVQMTQNEDLRENMLRQVLQHLSQQSESQYLKILTGLAEVATTNGH 316

  Fly   407 LLKQINLNYERIEFQSPQQPSISNLLR------RALERSSTRGVNLMGVASSKQSKQQ------- 458
            .|..::.||:      .|..|:..::|      |....|.:.|:: ||...:|..:.|
Mouse   317 KLLSLSSNYD------AQMKSLLRIVRIFCHVFRIGPSSPSNGID-MGYNGNKTPRSQVFKPLEL 374

  Fly   459 -WRKLDSAEVVQVSRICGMYYAALNTLSQMKLDILTGICYSDNVLYDIW-LLITSLG-------- 513
             |..||...|:                      |.|.:..:.....||. :|:...|
Mouse   375 LWHSLDEWLVL----------------------IATELMKNKEDSTDITSILLKQKGQDQEAPSL 417

  Fly   514 -----PNCGMKEYL---------ELLKSETNLQ-----------KPQTAMLMLF---CDC----- 545
                 |..|..|.|         |:|..|....           ...:|::..|   |.|
Mouse   418 SAFEPPGPGSYESLPPGPGDSKPEVLAGEQEASADCQDVISVTANRLSAVIQAFYMCCSCQMPPG 482

  Fly   546 MT--HYVTILDEHEMYTEQNPFKLNDYVLLTYFLNNILYKLINDNLLAGAKNIVQHPVFLSLHTL 608
            ||  .::..:.:|:                     .:|...:|.|    .|.|..|     .|.|
Mouse   483 MTSPRFIEFVCKHD---------------------EVLKCFVNRN----PKIIFDH-----FHFL 517

  Fly   609 MLCLYRRDCRRPFTPPKHWLIPEVKPSTFINDLEKAKRNAMLLLAKMPHII---PHEDRVKLFRK 670
            :.|                  ||                   |:::..|||   |.:||.:.|.:
Mouse   518 LEC------------------PE-------------------LMSRFMHIIKAQPFKDRCEWFYE 545

  Fly   671 FVQNEKAVMGLTESACASPRSALIVIHRDRIVEDGYRQLAAQPTQALKGVIRVRFINQQGLHEAG 735
            .:.:.:....:.....:  .:.::::|||.|.......::......||..|.|||..::|:.:
Mouse   546 HLHSGQPDSDMVHRPVS--ENDILLVHRDSIFRSSCEIVSKANCAKLKQGIAVRFHGEEGMGQ-- 606

  Fly   736 IDQDGVFKEFLEETIKKVFDPSLNLFKTTSDQRLY-PSPISYVQDNHLELFEFVGRMLGKAVYEG 799
                ||.:|:.:....::.:|...||..::|...: |:..|||..:||..|.|.|::||.|:...
Mouse   607 ----GVVREWFDILSNEIVNPDYALFTQSADGTTFQPNSNSYVNPDHLNYFRFAGQILGLALNHR 667

  Fly   800 IVVDVPFASFFLSQLLGQTQQALYSCMDELPSLDNELYRSLTFIKHYKQDVSD--LNLTFSVDQD 862
            .:|::.|...|...:||     :.....::.|:|.|..::|.:|  ...|:||  |.|||||:.|
Mouse   668 QLVNIYFTRSFYKHILG-----IPVNYQDVASIDPEYAKNLQWI--LDNDISDLGLELTFSVETD 725

  Fly   863 VMGKIVTLALHPGGKARVVNDHNKLVYIHYMAFFHMNTQIREQTIAFNRGFRSIVNPEWLSLFSP 927
            |.|.:..:.|.|||.:.:|..:||..|:..:....|...|:.|..||.:||...:.|..:.||..
Mouse   726 VFGAMEEVPLKPGGGSILVTQNNKAEYVQLVTELRMTRAIQPQINAFLQGFHMFIPPSLIQLFDE 790

  Fly   928 PELQRLISGDTSPLDLKDLQKHTHYYGGFHDTHQVVCWLWDILAKDFTEEERKLFLKFVTSCSKP 992
            .||:.|:|| ...:|:.|..|:|.|..|:.....|:.|.|::: :|.|:|||.|.|:|||..|:.
Mouse   791 YELELLLSG-MPEIDVNDWIKNTEYTSGYEREDPVIQWFWEVV-EDITQEERVLLLQFVTGSSRV 853

  Fly   993 PLLGFAHLEPPFSIRCVEVSDDEDTGDTIGSVIRGFFAIRKKDPLNRLPTSSTCFNLLKLPNYQK 1057
            |..|||::..                   ||.::.|.........|.|||||||.|:||||.|..
Mouse   854 PHGGFANIMG-------------------GSGLQNFTIAAVPYTPNLLPTSSTCINMLKLPEYPS 899

  Fly  1058 KSTLRDKLRYAV 1069
            |..|:|:|..|:
Mouse   900 KEILKDRLLVAL 911

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG5087	NP_648279.1	IQCD	20..50	CDD:467745
		HECTc	694..1076	CDD:238033	121/379 (32%)
Hace1	XP_006512697.1	ANKYR	26..261	CDD:440430	52/307 (17%)
		ANK repeat	66..95	CDD:293786	7/37 (19%)
		ANK repeat	97..128	CDD:293786	6/30 (20%)
		ANK repeat	130..161	CDD:293786	4/31 (13%)
		ANK repeat	163..194	CDD:293786	7/32 (22%)
		ANK repeat	196..233	CDD:293786	10/37 (27%)
		HECTc	566..915	CDD:238033	121/380 (32%)