DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5087 and hecd-1

DIOPT Version :9

Sequence 1:	NP_648279.1	Gene:	CG5087 / 39035	FlyBaseID:	FBgn0035953	Length:	1078	Species:	Drosophila melanogaster
Sequence 2:	NP_001368365.1	Gene:	hecd-1 / 177486	WormBaseID:	WBGene00016405	Length:	2650	Species:	Caenorhabditis elegans

Alignment Length:	771	Identity:	173/771 - (22%)
Similarity:	278/771 - (36%)	Gaps:	202/771 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   412 NLNYERIEFQSP--------QQPSISNLLRRALERSSTRGVNLMGVASSKQSKQQWRKLDSAEVV 468
            |:| :.:|.:.|        .:.|.|.:.:....|...||.|:.||.:.......    |||.:.
Worm  1978 NVN-QTLEVELPTVVKDFGSTKASSSKIDKDDQMRFFLRGPNMSGVDNVTIEMND----DSASLF 2037

  Fly   469 QVSRIC--GMYYAALNTLSQMKLDILTGICY--SDNVLYDIWLLITSLGPN------CGMKEYLE 523
            :..:|.  .:.:|..:..|:...:....|||  :|....::     |..|:      |.:.:.||
Worm  2038 RYMQIINNSVNWATKSDRSRRIWEPTYSICYCSADQTNVEV-----SKIPDEESSTPCQVNQCLE 2097

  Fly   524 LLKSETNLQK--PQTAMLMLFCDCMTHYVTILDEHEMYTEQNPFKLNDYVL-----LTYFLNNIL 581
            .:...:.:|:  |:..        :|..|.|.|:..:...|   .|:|.::     |..:.:.::
Worm  2098 TIGLLSRIQQAMPEAE--------ITPNVFISDKLTLKVTQ---VLSDALVVAARSLPEWCSRLV 2151

  Fly   582 YKLINDNLLAGAKNIVQHPVFLSLHTLMLCLYRRDCRRPFTPPKHWLIPEVKPSTFINDLEKAKR 646
            ||......:......:|...|....|::....|||..                      :|:|:.
Worm  2152 YKYPCLFTVETRNMYMQATAFGVSRTIVWLQQRRDAA----------------------VERARG 2194

  Fly   647 NAML--LLAKMPHIIPHEDRVKLFRKFVQNEKAVMGLTESACASPRSALIVIHRDRIVEDGYRQL 709
            :|..  ..|...|...||.||...|    :|:..:...|.........|:..|.||
Worm  2195 SAQAGNSSAARQHDRYHEYRVGRLR----HERVKVTRAEETLLDQAIRLMKFHADR--------- 2246

  Fly   710 AAQPTQALKGVIRVRFINQQGLHEAGIDQDGVFKEFLEETIKKVFDPSLNLFKTTSDQR------ 768
                    |.|:.:.:.|::|   .|:   |...||......::...||.|:....|..
Worm  2247 --------KAVLEIEYTNEEG---TGL---GPTLEFYALVAAELQRKSLALWVCDDDDTHASKSG 2297

  Fly   769 -----------------------LYPSPISYVQD---NHLELFEFVGRMLGKAVYEGIVVDVPFA 807
                                   |:|:|:....|   ...::|..:|..|.|.:.:|.:||:|.:
Worm  2298 EEREVDLGEGKKPIGYYVRRVGGLFPAPLPPGTDETKRAADMFRVLGVFLAKVLLDGRLVDLPLS 2362

  Fly   808 SFFLSQLL---------GQTQQALYSCMD-------------ELPSL--------------DNEL 836
            ..||..|:         |.....:.|..|             ||.:|              .|..
Worm  2363 RPFLKLLVHPQIGDDARGPNLHKILSLDDFEEVNPVKGSFLKELRALAQRKRLIENDTSIDSNSK 2427

  Fly   837 YRSLTFIK-HYKQD---VSDLNLTFSVDQDVMGKIVTLA---LHPGGKARVVNDHNKLVYIHYMA 894
            .|.:..:| |.|..   |.||.|.|:|:..  .|:...|   |..||....|...|...|:....
Worm  2428 RRKIAELKLHIKGSTCRVEDLALNFTVNPP--SKVFQYAEMELVDGGSDIDVTIDNVEQYVEKCE 2490

  Fly   895 FFHMNTQIREQTIAFNRGFRSIVNPEWLSLFSPPELQRLISGDTSP-LDLKDLQKHTHYYGGFHD 958
            .|::||.|..|..||..||..:.....|..:||.|:|||:||:..| ....|:..:|....|:..
Worm  2491 EFYLNTGIAYQMRAFRDGFDRVFPLRTLRAYSPEEVQRLLSGEQCPEWSRDDILNYTEPKLGYTR 2555

  Fly   959 THQVVCWLWDILAKDFTEEERKLFLKFVTSCSKPPLLGFAHLEPPFSI-RCVEVSDDEDTGDTIG 1022
            .........|:: :..|.:|||.||:|.|.||..|..|.|:|.|..:| |.||..|        |
Worm  2556 ESPGFLRFVDVM-EALTAQERKNFLQFATGCSSLPPGGLANLHPRLTIVRKVESGD--------G 2611

  Fly  1023 SVIRGFFAIRKKDPLNRLPTSSTCFNLLKLPNYQKKSTLRDKLRYAVSSNTGFELS 1078
            |                .|:.:||.:.||||.|...:.||::|..|::.. ||.|:
Worm  2612 S----------------YPSVNTCVHYLKLPEYSSSAILRERLLTAINEK-GFHLN 2650

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5087	NP_648279.1	HECTc	694..1076	CDD:238033	113/458 (25%)
CG5087	NP_648279.1	HECTc	718..1075	CDD:214523	109/433 (25%)
hecd-1	NP_001368365.1	Ank_2	345..436	CDD:403870
		ANK repeat	345..372	CDD:293786
		ANK repeat	374..403	CDD:293786
		PTZ00322	383..>497	CDD:140343
		ANK repeat	405..436	CDD:293786
		F5_F8_type_C	1243..1365	CDD:419973
		MIB_HERC2	1452..1509	CDD:399589
		HECTc	2221..2648	CDD:238033	116/477 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900