DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5087 and oxi-1

DIOPT Version :9

Sequence 1:	NP_648279.1	Gene:	CG5087 / 39035	FlyBaseID:	FBgn0035953	Length:	1078	Species:	Drosophila melanogaster
Sequence 2:	NP_499392.1	Gene:	oxi-1 / 176515	WormBaseID:	WBGene00003898	Length:	1066	Species:	Caenorhabditis elegans

Alignment Length:	1133	Identity:	421/1133 - (37%)
Similarity:	604/1133 - (53%)	Gaps:	139/1133 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 LEQTKAAREERALEKRREQAAILLQSTLKGYAARRKYQKRIILDFDAMFTENHDDKDAELELVAS 75
            |::....|||...::||.:.|..|:..|.||..|:|:..:|.......|.:.:|     ||....
Worm     8 LQKNAREREEEETQRRRIELAHKLEPYLIGYLTRKKFHGKIKTFRPTFFNDFND-----LEKSNK 67

  Fly    76 NVYPVLRRYLTQIRL-----DKSDVRARERLERICRYIIKAMESENTKLSYAALCLFKERSLPWI 135
            .:.||.:..:...|:     :..|:   :.|..|||::|.:::|.:.::|:.|..|.|:.    |
Worm    68 TLLPVAQMLVKVPRVIENSRENKDI---QMLCNICRHLIISIDSPSKEISFVAAFLNKDT----I 125

  Fly   136 AHIKILLTNCLTLLPE----LKPENHADSLSLALFLHTLVVFTAPKSWAILRNAQFEKLQPAMQK 196
            .....|:|:..:.:|:    :..|..|:.......:|.::||::..:|.::|||  .::|..:..
Worm   126 KEATSLITSIFSQIPQILCSINGERAAELKQWQCLIHFVIVFSSSSNWLLVRNA--PQVQTVLNG 188

  Fly   197 ICCNIQGHLVQHDFYKIMRLVLIRGTVREELSVKPVTLVAIITLCLRPLIDGNFSRNLLAKFLSE 261
            :|..:.....:...|:.|...|.......:..:...|:.|..::..:||...|  ..|.:.|:.:
Worm   189 LCVKMMSLFYEPKGYEQMATSLFVSVNGHKPLINVETVNAQFSILCKPLKTEN--PELFSIFVLK 251

  Fly   262 ILSVPALIYHLQQSVPQCLEQFSSMGLLKKALSISGDVQWF----EEFGTSMPGTKSLAFLGNIV 322
            :|:.|||:.||.   .|.:|...:..:.:|.|      .|.    ||..|.|.....:..|.|:|
Worm   252 VLTCPALLVHLN---AQHVELLKTTKIFEKTL------HWLRANAEEIETGMDVRLLINLLANLV 307

  Fly   323 NLFNI-DGQGESKELAYPLLTETTTSLLELIPNTVTTKGVFTQ---WHELLGWHTPGPEPAQNQN 383
            :...| |...|||  .|........||......||...|..|.   ||.:.|.:.   .|...:.
Worm   308 HFAYINDKTLESK--LYEWTWAVGVSLSRCTELTVKHGGTKTSLHYWHPVFGHYL---LPIDKRT 367

  Fly   384 VALIKK---QFHMLWDHRCIKLLLGDLLKQINLNYERIEFQSPQQPSISNLLRRALERSSTRGVN 445
            ...::.   |..|||..|.::.|.|::::                              :|:..:
Worm   368 EGALRNVLFQLKMLWSSRVVRCLFGNIME------------------------------NTKTAS 402

  Fly   446 LMGVASSKQSK-------QQWRKL----DSAEVVQVSR----------ICGMYYAALNTLSQMKL 489
            .......|.||       :.||||    |||.....|.          :|.:|..||||:..||.
Worm   403 FSVTDGQKNSKDISAAFSKLWRKLGGSTDSASSSSKSESEPPPTLIAIVCQVYMTALNTMVHMKG 467

  Fly   490 DILTGICYSDNVLYDIWLLITSLGPNCG-----------------MKEYLELLKSETNLQKPQTA 537
            :|::|:|..|.:|..:|..:...|...|                 :...|:.||..::   |.||
Worm   468 EIISGLCRDDQLLKQLWTYLREWGEKAGGTSGSIFNSSNAEQWGPVSASLQSLKRPSS---PHTA 529

  Fly   538 MLMLFCDCMTHYVTILDEHEMYTEQNPFKLNDYVLLTYFLNNILYKLI----NDNLLAGAKNIVQ 598
            .|.||.||....::||||.|::.::.||...:...:..::|...::.|    .|...|....:
Worm   530 TLRLFVDCAAAIISILDEEEIFEKETPFSNKELESICKYVNIFCFRSIWSGAVDETSANTTGL-- 592

  Fly   599 HPVFLSLHTLMLCLYRRDCRRPF--TPPKHWLIPEVKPSTFINDLEKAKRNAMLLLAKMPHIIPH 661
               |.|:|:|:..||.||.||.|  ...|.|||.|||||:...:.||.....:|::.||.|::|.
Worm   593 ---FHSMHSLLTVLYERDSRRSFAANDSKFWLISEVKPSSLTIEYEKKSGKGVLMMRKMAHLVPI 654

  Fly   662 EDRVKLFRKFVQNEKAVMGLTESACASPR-SALIVIHRDRIVEDGYRQLAAQPTQALKGVIRVRF 725
            :||:.|||:.||::|   ....::...|: ...|.:.|:||:|||:..|:.....|||..|||:|
Worm   655 KDRMLLFRRQVQDDK---NRVATSLNDPQMQTWITVQRNRIIEDGFNHLSKLTIPALKSTIRVKF 716

  Fly   726 INQQGLHEAGIDQDGVFKEFLEETIKKVFDPSLNLFKTTSDQRLYPSPISYVQDNHLELFEFVGR 790
            :|:|||.|||||||||||||||.|:||||||.||||.|||...|||||.|.:.|:||.||.||||
Worm   717 VNEQGLDEAGIDQDGVFKEFLELTLKKVFDPQLNLFSTTSTGVLYPSPTSSLHDDHLALFTFVGR 781

  Fly   791 MLGKAVYEGIVVDVPFASFFLSQLLGQTQQALYSCMDELPSLDNELYRSLTFIKHYKQDVSDLNL 855
            ||||||||||||||..|...|:.:||..:...:   |||..||.||||||||:|.|:.:::||:|
Worm   782 MLGKAVYEGIVVDVQLAPVLLAAVLGSHRLCAF---DELSQLDPELYRSLTFVKRYEGEMADLSL 843

  Fly   856 TFSVDQDVMGKIVTLALHPGGKARVVNDHNKLVYIHYMAFFHMNTQIREQTIAFNRGFRSIVNPE 920
            |||||:|.||||.|:.|.|.|:...|.:.||:.|:|.||...:..:.:||..||..|.:||:.|.
Worm   844 TFSVDEDFMGKISTVDLVPSGRTISVTNENKIDYVHRMAHHRVFRRTQEQCKAFVTGMQSILQPT 908

  Fly   921 WLSLFSPPELQRLISGDTSPLDLKDLQKHTHYYGGFHDTHQVVCWLWDILAKDFTEEERKLFLKF 985
            |||||:|.:||.||||..|.:||.||:::..|:||||..|:::.||||||...||.|||||||||
Worm   909 WLSLFAPNDLQCLISGVNSDIDLADLKRNVQYFGGFHGNHRLIKWLWDILENKFTSEERKLFLKF 973

  Fly   986 VTSCSKPPLLGFAHLEPPFSIRCVEVSDDEDTGDTIGSVIRGFFAIRKKDPLNRLPTSSTCFNLL 1050
            |||||:||:|||::|||||||||||||||:|.|||:|||:|||.|:||.....||||:|||||||
Worm   974 VTSCSRPPVLGFSYLEPPFSIRCVEVSDDQDQGDTLGSVVRGFLALRKGTAATRLPTASTCFNLL 1038

  Fly  1051 KLPNYQKKSTLRDKLRYAVSSNTGFELS 1078
            |||||.|||.|.:|||||:.:.||||||
Worm  1039 KLPNYNKKSLLLEKLRYAIHAGTGFELS 1066

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5087	NP_648279.1	HECTc	694..1076	CDD:238033	233/381 (61%)
CG5087	NP_648279.1	HECTc	718..1075	CDD:214523	222/356 (62%)
oxi-1	NP_499392.1	HECTc	684..1064	CDD:238033	233/382 (61%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160161688
Domainoid	1	1.000	406	1.000	Domainoid score	I360
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H13775
Inparanoid	1	1.050	657	1.000	Inparanoid score	I407
Isobase	1	0.950	-	0	Normalized mean entropy	S2001
OMA	1	1.010	-	-		QHG48068
OrthoDB	1	1.010	-	-		D1163565at2759
OrthoFinder	1	1.000	-	-		FOG0006345
OrthoInspector	1	1.000	-	-		oto17707
orthoMCL	1	0.900	-	-		OOG6_100865
Panther	1	1.100	-	-	LDO	PTHR45700
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1831
SonicParanoid	1	1.000	-	-		X4619
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	17	16.750