DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5087 and hecw-1

DIOPT Version :9

Sequence 1:	NP_648279.1	Gene:	CG5087 / 39035	FlyBaseID:	FBgn0035953	Length:	1078	Species:	Drosophila melanogaster
Sequence 2:	NP_001317872.1	Gene:	hecw-1 / 175438	WormBaseID:	WBGene00009738	Length:	1247	Species:	Caenorhabditis elegans

Alignment Length:	1239	Identity:	254/1239 - (20%)
Similarity:	457/1239 - (36%)	Gaps:	314/1239 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    57 AMFTENHDDKDAELELV--ASNVYPVLRRYLTQIRLDK---SDVRARERLERICRYII--KAMES 114
            |.:||::|.::|.|.::  ..:::......:|.:.:|.   .|.||      ||...:  |.:|.
Worm   104 AFYTEHYDLENAMLVVIRYMISIFKCSNSIITYLSIDLGVIEDSRA------ICENFVAFKKVER 162

  Fly   115 ----------ENTKLSYAALCLFKERSLPWIA---HIKILLTNCLTLLPELKPENHAD---SLSL 163
                      |...|::|       :|..||.   .||.:......|.|::..:.:.:   .|..
Worm   163 LSIFQTNYGVERNTLNFA-------QSFDWICDNLEIKNIHIGADVLEPKMVQKTNGEFDIKLCA 220

  Fly   164 ALFLHTLV---VFTAPKSWAILRNAQFEKLQPAMQKICCNIQGHLVQHDFYKIM----------- 214
            ..|...|.   ::.....|....:.....:|.||.     |:.:|.:.|....:
Worm   221 RRFEQVLTMDHIYLQHADWITSEDLLNLDVQTAML-----IENNLTEQDLNAFIKQWLRSDSDKL 280

  Fly   215 -------RLVLIRGTVREELSVKPVTLVAIITLCL-----RPLIDGN-FSRNLLAKFLSEILSV- 265
                   :::..|..|.::|.|:.....::.|...     |....|| .:|..:.....::..:
Worm   281 WWLEVKGKMMFNREEVLKDLDVQDDAYRSLNTRWYVARRSRANPSGNGCARKKMGSLRPKLTELW 345

  Fly   266 PALIYHLQQSV-----PQCLEQFSSMGLLKKALSISGDVQWFEEFGTSMPGTKSLAF-LGN---I 321
            |..:|.:..|:     |..|.:..::    :.:.:..|.....|.|..:  :||..: .||   :
Worm   346 PFKVYIIFGSILIVFGPAALNRMITL----RRMDVETDRPSGSETGIFV--SKSAVYPFGNKNEV 404

  Fly   322 VNL-FNID---------GQGESKELAYPLLTETTTSLLELIPNTVTTKGVFTQ---WHELLGWHT 373
            |.: :|||         |..::.:.::.|..::....:..:..|:|:|.:...   :..|:...|
Worm   405 VKVWWNIDKPENCLDWIGLFDNNDSSFYLDQKSLRQHISPVVFTLTSKNLLNASEVYFGLIDGMT 469

  Fly   374 PGPEPAQNQNVALIKKQFHMLWDHRCIKLLLGDLLK------QINLNYERIEFQSPQQPSI---- 428
             |...|:::||.:.|.          ..|::.::.|      .:|.|:.|||.  |::.|.
Worm   470 -GRLLAKSENVEICKS----------ASLVVHEVKKPENINVYLNTNHGRIEI--PKKRSFSRKN 521

  Fly   429 ----------------------------------SNLLRR------------------ALERSST 441
                                              ||.|:.                  ::|..::
Worm   522 GSFRSSFEFDFDVEDLHISLVENSEKLNFDHFIASNQLQNNYIQSKSFSHSHVVEIVFSIEPKTS 586

  Fly   442 R--GVNLMGVASSKQS--KQQW--------RKLDSAEVVQVSRICGMYYAALNTLSQMKLDILTG 494
            :  ..::|.:|||.|:  :..|        ||.....|.:.:|     :...:||:...::..|.
Worm   587 KKSAPDIMEIASSSQTPPESHWKTYLDAKKRKFYVNHVTKETR-----WTKPDTLNNNHIEPETP 646

  Fly   495 I--CYSD------NVLYDIWLLITSLGPNCGMKEYLELLKSE---TNLQKPQTAM-LMLFCDCMT 547
            :  ..||      |........||.....|...:.::..:.:   |.|.:.|.|| :...|..:.
Worm   647 VHKRLSDRSASPRNSFITPRRTITVRSAGCPKSDLIQFFQRDEFKTALYENQDAMQIYNECSVVR 711

  Fly   548 HYVTILDEHEMYTEQN-PFKLNDYVLLTYFLNNILYKLINDNLLAGAKNIVQH--PVFLSLHTLM 609
            |.:     |.:..:.: |.|..:..|...|:|  |:..|...|.:|.:.|..:  .|||:.....
Worm   712 HAI-----HRIQKDLDPPSKFENQPLFVRFVN--LFADITQPLPSGWECITMNNRTVFLNHANKE 769

  Fly   610 LCLY--------RRDCRRPFTPPK-----------HWLIP------EVKPSTFINDLEKAKRNAM 649
            ...|        .:..||..:.|.           |.||.      ::....|....|:..:..|
Worm   770 TSFYDPRIRRFETKTSRRGRSVPSRSSTAHKGKIDHALISKCEDLRKIAQDNFPQIAERISKKLM 834

  Fly   650 LL-------LAKMPH-----------------IIPHEDRVKLFRKFVQNEKAVMGLTESACASPR 690
            |:       :|.:.:                 :....|.:|:|.:.::.||...|        |.
Worm   835 LIERFGGLAVASLANDLDITLALSMLDSNTEKLAGEGDNIKMFYEDMKKEKLGKG--------PS 891

  Fly   691 SALIVIHRDRIVEDGYR-QLAAQPTQALKGVIRVRFINQQGLHEAGIDQDGVFKEFLEETIKKVF 754
            .....:.|||:::|.:| .|...|....|..:.:||   :|  |..:|..|:.:||.....:::|
Worm   892 RLCWKVSRDRLLDDAFRIILNVDPFVLKKSRLHIRF---EG--ELALDYGGLSREFFILLSRELF 951

  Fly   755 DPSLNLFK-TTSDQRLYPSPISYVQDNHLELFEFVGRMLGKAVYEGIVVDVPFASFFLSQLLGQT 818
            .|....|: ..:|..|...|.....:...:.....||:|..||.....:||.|.:.|...|
Worm   952 HPKNGYFEYEGNDYHLQLRPRGCETEKEKKWLILCGRVLALAVIHRCYIDVFFTNVFYKSL---- 1012

  Fly   819 QQALYSCMDELPSLDNELYRSLTFIKHYKQDVSDLNLTFSVDQDVMGKIVTLALHPGGKARVVND 883
            |:...:.||...| |.|.|:|:.::  .:.||.||.::|.....|.||:....|.|||::::|.:
Worm  1013 QKRPVTLMDFKES-DAEFYKSMNWL--LENDVVDLEMSFVYSSMVNGKLAEQELVPGGESQMVTE 1074

  Fly   884 HNKLVYIHYMAFFHMNTQIREQTIAFNRGFRSIVNPEWLSLFSPPELQRLISGDTSPLDLKDLQK 948
            .||..:|..|........:.:........|..|:|...|:.....:|:|::||... |||.|.:.
Worm  1075 ANKAEFIDLMCQKKAIRGVEKPLEILLTSFNQILNDNLLNSLESSDLKRILSGSLE-LDLNDWRT 1138

  Fly   949 HTHYYGGFHDTHQVVCWLWDILAKDFTEEERKLFLKFVTSCSKPPLLGFAHLEPPFSIRCVEVSD 1013
            :|.|.||:.|.|.||.|.|::: :..|.:||...|.|||..|..|..||
Worm  1139 NTIYKGGYSDCHIVVEWFWEVI-ETMTNQERFDLLLFVTGSSSVPFEGF---------------- 1186

  Fly  1014 DEDTGDTIGSVIRG-----FFAIRKKDPLNRLPTSSTCFNLLKLPNYQKKSTLRDKLRYAVSSNT 1073
                     |.:||     .|.|.|.......|.:.||||.|:||:|..|..|:.||:.|:.:..
Worm  1187 ---------SALRGNEEISKFCIEKWGDATSFPRAHTCFNRLQLPSYNTKQQLKSKLQQAIVNGM 1242

  Fly  1074 GFEL 1077
            .:.:
Worm  1243 SYSI 1246

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5087	NP_648279.1	HECTc	694..1076	CDD:238033	110/388 (28%)
CG5087	NP_648279.1	HECTc	718..1075	CDD:214523	103/362 (28%)
hecw-1	NP_001317872.1	FBA_2	230..285	CDD:311601	7/59 (12%)
		WW	603..634	CDD:197736	5/35 (14%)
		WW	746..777	CDD:197736	7/30 (23%)
		HECTc	918..1244	CDD:214523	103/364 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810