Protein Alignment CG5087 and herc-1

DIOPT Version :10

• Sequence 1: NP_648279.1
• Gene: CG5087 / 39035
• FlyBaseID: FBgn0035953
• Length: 1078
• Species: Drosophila melanogaster
• Sequence 2: NP_490834.1
• Gene: herc-1 / 171700
• WormBaseID: WBGene00021685
• Length: 1019
• Species: Caenorhabditis elegans
• Alignment Length: 864
• Identity: 194/864 - (22%)
• Similarity: 311/864 - (35%)
• Gaps: 276/864 - (31%)

  Fly   326 NIDGQ-GESKELAYPLLTETTTSLLELIPNTVTTKGVFTQWHELLGWHTPGPEPAQNQNVA-LIK 388
            |..|| |..|     ::|::|....:.:.:..   |||..:|:.....:.| ...||:.|. ...
 Worm   321 NSSGQLGNGK-----IMTQSTPRKTDELDHVT---GVFAGYHQTFFVRSSG-TIEQNEIVGPSCP 376

  Fly   389 KQFHMLWDHRCIKLLL--GDLLKQINLNYERIE--FQSPQQPSISNLL---RR-----ALERSST 441
            .|:.:..||..:|.||  ||.|:.::|    ||  |.|....::|.|.   ||     ..|||
 Worm   377 MQYPIKLDHESLKKLLDEGDALEVMSL----IESVFSSLASMNMSFLYKDERRYNVGFCFERS-- 435

  Fly   442 RGVNLMGVASSKQSKQQWRKLDSAEVVQVSRICGMYYAALNTLSQMKLDILTGICYSDNVLYDIW 506
                              ..:|..:|::...:...|        .||...:.
 Worm   436 ------------------HGIDMDQVMEAFMLFDEY--------PMKRQYME------------- 461

  Fly   507 LLITSLGPNCGMKEYLELLKSETNLQKPQTAMLMLFCDCMTHYVTILDEHEMYTEQNPFKLNDYV 571
            |::.||  ....:|:.|.||....|:    .:|||                      |:
 Worm   462 LIVDSL--KIAFQEWSENLKGIECLR----VLLML----------------------PW------ 492

  Fly   572 LLTYFLNNILYKLINDNLLAGAKNIVQHPVFLSLHTLMLCLYRRDCRRPFTPPKHW--------- 627
             |..|..|:..:.|        ||:  |..|:.    .:||...|.|...  .|.|
 Worm   493 -LPIFTENVNVQTI--------KNV--HTPFVD----AMCLITGDLRAAL--EKWWTQLSTRHFR 540

  Fly   628 -LIPEVKPSTFINDLEKAKR------------NAMLLLAKMPHIIPHE----DR----------- 664
             ::...|  |.|..:.|||:            ..:.|:.|..||||.|    |.
 Worm   541 RMVTVFK--TAIKAMLKAKKGPRDCHKFILIMQKLSLINKTYHIIPLETFYIDELNTSVDLKLEY 603

  Fly   665 -VKLFRK--------------FVQNEKAVMGL------------TESACASPRSALIV------- 695
             ::|.|:              |:.|..|...|            .:|:..:.....|:
 Worm   604 VLELTRQDPNKTELDYWTHFPFLLNGVAKGELIFVEAWLMQTLRRQSSLFNTAHGTIIFELPHLE 668

  Fly   696 --IHRDRIVEDGYRQLAAQPTQALKGVIRVRFINQQGLHEAGIDQD---GVFKEFLEETIKKVFD 755
              :.|:.||.|...|:|......|:..::|..        ||.|.|   ||.|||....::|:..
 Worm   669 LTVRREFIVSDTMNQMAGLSESDLQKPLKVNI--------AGEDADDAGGVRKEFFILVMRKILQ 725

  Fly   756 PSLNLFKTTSDQRL-----YPSPISYVQDNHLELFEFVGRMLGKAVYEGIVVDVPFASFFLSQLL 815
            ....:|....:..|     .||...     ..|.|..:||::|.::|...:|..||
 Worm   726 SDYGMFSEDEESHLVWFSGLPSEFC-----DREQFHQLGRLVGLSIYNHSIVPFPF--------- 776

  Fly   816 GQTQQALYS-CMDELPSLDN--ELY----RSLTFIKHYKQ-DVSDL-NLTFSVDQDVMGKIVTLA 871
               ..|||. .:|..|.|::  ||.    :.|..:..|:: ||.|: .|.|.:..:::|:..|..
 Worm   777 ---PLALYKYLLDTPPDLEDLCELSPSEGKGLKMLLSYEEDDVEDVFGLNFCISFNILGETHTTE 838

  Fly   872 LHPGGKARVVNDHNK----LVYIHYMAFFHMNTQIREQTIAFNRGFRSIVNPEWLSLFSPPELQR 932
            |..||..:.|.:.|:    .:|:|:......|.:|.:|.:.|.:||...::...|..|.|.||:.
 Worm   839 LLSGGTEKPVTNANRDEYVRLYVHHRLELGYNGEIAQQALLFRKGFSESLHSRTLRFFQPCELKE 903

  Fly   933 LISGDTSPLDLKDLQKHTHYYGGFHDTHQVVCWLWDILAKDF---TEEERKLFLKFVTSCSKPPL 994
            :|.|:.: .|..:.:....|.|.:..:|..:...|    |.|   |::||:.||:|:|..::.|:
 Worm   904 MIVGNEN-YDWNEFRDILMYRGEYSSSHPTIQAFW----KAFFALTDDERRKFLQFLTGSTRIPV 963

  Fly   995 LGFAHLEPPFSIRCVEVSDDEDTGDTIGSVIRGFFAIRKKDPLNRLPTSSTCFNLLKLPNYQKKS 1059
            .|:..|..                           ||:...| ..||.:.||||||.|||.....
 Worm   964 SGWEELHA---------------------------AIQPSAP-ESLPVAHTCFNLLDLPNIADDV 1000

  Fly  1060 TLRDKLRYAVSSNTGFELS 1078
            .|..:||.::....||.|:
 Worm  1001 ELLRRLRISIEHTEGFTLA 1019

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG5087	NP_648279.1	IQCD	20..50	CDD:467745
		HECTc	694..1076	CDD:238033	104/414 (25%)
herc-1	NP_490834.1	RCC1	7..56	CDD:395335
		ATS1	44..365	CDD:444065	12/52 (23%)
		HECTc	667..1016	CDD:238033	102/406 (25%)