DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5087 and Itch

DIOPT Version :9

Sequence 1:	NP_648279.1	Gene:	CG5087 / 39035	FlyBaseID:	FBgn0035953	Length:	1078	Species:	Drosophila melanogaster
Sequence 2:	NP_001230641.1	Gene:	Itch / 16396	MGIID:	1202301	Length:	864	Species:	Mus musculus

Alignment Length:	441	Identity:	126/441 - (28%)
Similarity:	205/441 - (46%)	Gaps:	53/441 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   655 MPHIIPHEDRVKLF---------------RKFVQNEKAVMGLTESAC---ASPRSALIVIHRDRI 701
            :|:.:.|..|...:               ..:|::.||.:......|   |.|:...|.:.|..:
Mouse   454 IPYFVDHNRRATTYIDPRTGKSALDNGPQIAYVRDFKAKVQYFRFWCQQLAMPQHIKITVTRKTL 518

  Fly   702 VEDGYRQLAAQPTQALKGVIRVRFINQQGLHEAGIDQDGVFKEFLEETIKKVFDPSLNLFKTTSD 766
            .||.::|:.:...|.|:..:.|.|..::||     |..||.:|:......:|.:|...||:....
Mouse   519 FEDSFQQIMSFSPQDLRRRLWVIFPGEEGL-----DYGGVAREWFFLLSHEVLNPMYCLFEYAGK 578

  Fly   767 QR--LYPSPISYVQDNHLELFEFVGRMLGKAVYEGIVVDVPFASFFLSQLLGQTQQALYSCMDEL 829
            ..  |..:|.||:..:||:.|.|:||.:..|::.|..:|..|:..|..::|.:...     :.:|
Mouse   579 DNYCLQINPASYINPDHLKYFRFIGRFIAMALFHGKFIDTGFSLPFYKRILNKPVG-----LKDL 638

  Fly   830 PSLDNELYRSLTFIKHYKQDVSDLNLTFSVDQDVMGKIVTLALHPGGKARVVNDHNKLVYIHYMA 894
            .|:|.|.|.||.::|....:...|.:.||||::::|:|.:..|.|.|...:|.:.||..||..:|
Mouse   639 ESIDPEFYNSLIWVKENNIEECGLEMYFSVDKEILGEIKSHDLKPNGGNILVTEENKEEYIRMVA 703

  Fly   895 FFHMNTQIREQTIAFNRGFRSIVNPEWLSLFSPPELQRLISGDTSPLDLKDLQKHTHYYGGFHDT 959
            .:.::..:.|||.||..||..|:..::|..|...||:.|:.| ...:||.|.|:|. .|..:..|
Mouse   704 EWRLSRGVEEQTQAFFEGFNEILPQQYLQYFDAKELEVLLCG-MQEIDLNDWQRHA-IYRHYTRT 766

  Fly   960 HQVVCWLWDILAKDFTEEERKLFLKFVTSCSKPPLLGFAHLEPPFSIRCVEVSDDEDTGDTIGSV 1024
            .:.:.|.|..: |:...|:|...|:|||...:.|:.|||                    |.:||.
Mouse   767 SKQIMWFWQFV-KEIDNEKRMRLLQFVTGTCRLPVGGFA--------------------DLMGSN 810

  Fly  1025 IRGFFAIRKKDPLNRLPTSSTCFNLLKLPNYQKKSTLRDKLRYAVSSNTGF 1075
            ....|.|.|....|.||.|.||||.|.||.|:....|::||.:|:....||
Mouse   811 GPQKFCIEKVGKENWLPRSHTCFNRLDLPPYKSYEQLKEKLLFAIEETEGF 861

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5087	NP_648279.1	HECTc	694..1076	CDD:238033	117/384 (30%)
CG5087	NP_648279.1	HECTc	718..1075	CDD:214523	108/358 (30%)
Itch	NP_001230641.1	C2_E3_ubiquitin_ligase	17..140	CDD:175988
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	151..294
		WW	289..318	CDD:278809
		WW	321..350	CDD:278809
		Required for interaction with FYN. /evidence=ECO:0000250	356..432
		WW	401..430	CDD:278809
		WW	440..471	CDD:197736	3/16 (19%)
		HECTc	509..862	CDD:238033	117/386 (30%)
		HECTc	533..861	CDD:214523	109/360 (30%)
		MAP kinase docking site	535..544		2/8 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810